ID M1VR96_STRSU Unreviewed; 441 AA.
AC M1VR96;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Regulatory protein MsrR {ECO:0000256|ARBA:ARBA00040752};
OS Streptococcus suis.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1307 {ECO:0000313|EMBL:BAM94533.1};
RN [1] {ECO:0000313|EMBL:BAM94533.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NCTC10237 {ECO:0000313|EMBL:BAM94533.1};
RX PubMed=23416996; DOI=10.1128/AEM.03742-12;
RA Okura M., Takamatsu D., Maruyama F., Nozawa T., Nakagawa I., Osaki M.,
RA Sekizaki T., Gottschalk M., Kumagai Y., Hamada S.;
RT "Genetic analysis of capsular polysaccharide synthesis gene clusters from
RT all serotypes of Streptococcus suis: potential mechanisms for generation of
RT capsular variation.";
RL Appl. Environ. Microbiol. 79:2796-2806(2013).
CC -!- FUNCTION: Involved in SarA attenuation. Affects resistance to oxacillin
CC and teicoplanin, as well as the synthesis of virulence factors.
CC {ECO:0000256|ARBA:ARBA00037178}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC -!- SIMILARITY: Belongs to the LytR/CpsA/Psr (LCP) family.
CC {ECO:0000256|ARBA:ARBA00006068}.
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DR EMBL; AB737817; BAM94533.1; -; Genomic_DNA.
DR RefSeq; WP_014736019.1; NZ_LR594043.1.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.630.190; LCP protein; 1.
DR InterPro; IPR004474; LytR_CpsA_psr.
DR NCBIfam; TIGR00350; lytR_cpsA_psr; 1.
DR PANTHER; PTHR33392; POLYISOPRENYL-TEICHOIC ACID--PEPTIDOGLYCAN TEICHOIC ACID TRANSFERASE TAGU; 1.
DR PANTHER; PTHR33392:SF8; REGULATORY PROTEIN MSRR; 1.
DR Pfam; PF03816; LytR_cpsA_psr; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 190..358
FT /note="Cell envelope-related transcriptional attenuator"
FT /evidence="ECO:0000259|Pfam:PF03816"
FT REGION 73..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 441 AA; 50210 MW; 8D051D9E681774C4 CRC64;
MNKNNNILTH HEQLRLDYLQ KNIHYLNDKE SRELDYLLYK KELRERHGSP RQSLRSFTPT
AYEDDYFEED YFEEDDEQEE LLPRYPERKS RKTRQAKPQR FQSPRISPKA KVPKPKKARK
KGGFKRFIGF VLLAIALVIV AMGYSFFKGM NSVSEKPVAE VFNGVDTSNG TNILILGTDG
RVGESSGETR TDTIMVLNVN NTDNKVKLVS FMRDTLVDIE GYEYKLNTAY TLGEQDNQQG
AEEVRKALKN SFDIDIKYYA MVDFATFATT IDTLFPEGVT IDAQFSTING EVVSSVEVPN
DLQLEENAPA YQTIQVGVQQ MDGTTLLNYA RYRSDDEGDF GRTRRQQEVL SAVMTQAKNP
MKLFSGSEAI GKVVAMTPTT VPQSFMWLQG PGLLLDAANG IERVTIPENG DWIDDYDMYG
GMALRVDFEK YQQRLAELGL R
//
