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Database: UniProt
Entry: M1WX08_DESPC
LinkDB: M1WX08_DESPC
Original site: M1WX08_DESPC 
ID   M1WX08_DESPC            Unreviewed;       432 AA.
AC   M1WX08;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   05-JUL-2017, entry version 38.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|RuleBase:RU000577};
GN   OrderedLocusNames=BN4_12198 {ECO:0000313|EMBL:CCH49433.1};
OS   Desulfovibrio piezophilus (strain DSM 21447 / JCM 15486 / C1TLV30).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Desulfovibrio.
OX   NCBI_TaxID=1322246 {ECO:0000313|EMBL:CCH49433.1, ECO:0000313|Proteomes:UP000011724};
RN   [1] {ECO:0000313|EMBL:CCH49433.1, ECO:0000313|Proteomes:UP000011724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 10523 / SB164P1 {ECO:0000313|Proteomes:UP000011724};
RX   PubMed=23383081; DOI=10.1371/journal.pone.0055130;
RA   Pradel N., Ji B., Gimenez G., Talla E., Lenoble P., Garel M.,
RA   Tamburini C., Fourquet P., Lebrun R., Bertin P., Denis Y.,
RA   Pophillat M., Barbe V., Ollivier B., Dolla A.;
RT   "The First Genomic and Proteomic Characterization of a Deep-Sea
RT   Sulfate Reducer: Insights into the Piezophilic Lifestyle of
RT   Desulfovibrio piezophilus.";
RL   PLoS ONE 8:e55130-e55130(2013).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|RuleBase:RU000577,
CC       ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; FO203427; CCH49433.1; -; Genomic_DNA.
DR   RefSeq; WP_015415477.1; NC_020409.1.
DR   EnsemblBacteria; CCH49433; CCH49433; BN4_12198.
DR   KEGG; dpi:BN4_12198; -.
DR   PATRIC; fig|879567.3.peg.2344; -.
DR   KO; K02313; -.
DR   OMA; DFRYLQG; -.
DR   OrthoDB; POG091H02FF; -.
DR   BioCyc; DPIE1322246:G13AY-2246-MONOMER; -.
DR   Proteomes; UP000011724; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011724};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011724}.
FT   DOMAIN      130    257       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      339    408       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
SQ   SEQUENCE   432 AA;  50596 MW;  7A6DD7BB36998E1A CRC64;
     MKQSLRKHLL QTNSNDDLKR WFDPLHIEYE EETKRIIVGF PHSFFAKWFE SDIQDKFEAQ
     LNMFLGSGYL VSYQDKSAGE RSTGVQAPDV VKRIDFPFGQ EFIFDTFLIN KKNYFPIASA
     KEVAKQTGSL FNPFIICGPG GSGKTHLIKS VGNEISKKHD YSNIFMGTMD ELNSLYAIQF
     RGDPFRARNH LFEYDFMFLD DFQKIREYPH FQQELVNIFN HFYDNKKQMV LACRDKVTSY
     DFLDDSLQSR LGWGLIVTLK EPDLEIRVGY IQRQCRIKRL VLNKEQILTL AQRFTDFRYL
     QGILLKLFAF KELVKKELTQ KDFEHILSNT EEKATDDLTP KKIMSVVSEH FNIRLGDMTG
     SKRHQHIAHA RQVAMFLCRQ MLKTSYPSLG RTFGGKDHST VLYSVKKINQ LQEDNYELKQ
     LLKTLKTKCR MT
//
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