ID M1XQJ4_NATM8 Unreviewed; 723 AA.
AC M1XQJ4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Sensor box histidine kinase {ECO:0000313|EMBL:CCQ36406.1};
DE EC=2.7.13.3 {ECO:0000313|EMBL:CCQ36406.1};
GN OrderedLocusNames=Nmlp_2234 {ECO:0000313|EMBL:CCQ36406.1};
OS Natronomonas moolapensis (strain DSM 18674 / CECT 7526 / JCM 14361 /
OS 8.8.11).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haloarculaceae; Natronomonas.
OX NCBI_TaxID=268739 {ECO:0000313|EMBL:CCQ36406.1, ECO:0000313|Proteomes:UP000011867};
RN [1] {ECO:0000313|EMBL:CCQ36406.1, ECO:0000313|Proteomes:UP000011867}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18674 / JCM 14361 / 8.8.11
RC {ECO:0000313|Proteomes:UP000011867};
RX PubMed=23516216; DOI=10.1128/genomeA.00095-13;
RA Dyall-Smith M.L., Pfeiffer F., Oberwinkler T., Klee K., Rampp M., Palm P.,
RA Gross K., Schuster S.C., Oesterhelt D.;
RT "Genome of the haloarchaeon Natronomonas moolapensis, a neutrophilic member
RT of a previously haloalkaliphilic genus.";
RL Genome Announc. 1:e0009513-e0009513(2013).
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DR EMBL; HF582854; CCQ36406.1; -; Genomic_DNA.
DR AlphaFoldDB; M1XQJ4; -.
DR STRING; 268739.Nmlp_2234; -.
DR KEGG; nmo:Nmlp_2234; -.
DR eggNOG; arCOG02364; Archaea.
DR eggNOG; arCOG02365; Archaea.
DR HOGENOM; CLU_333071_0_0_2; -.
DR Proteomes; UP000011867; Chromosome.
DR GO; GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR47429; PROTEIN TWIN LOV 1; 1.
DR PANTHER; PTHR47429:SF2; PROTEIN TWIN LOV 1; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF08448; PAS_4; 1.
DR Pfam; PF13426; PAS_9; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:CCQ36406.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011867};
KW Transferase {ECO:0000313|EMBL:CCQ36406.1}.
FT DOMAIN 256..305
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 330..384
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 381..451
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 511..722
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 84..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..32
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..64
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..110
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 723 AA; 80456 MW; 4D1272C81644BF08 CRC64;
MGPDPLRNSR GGRGAVRRGH RRADDARQRR SGRHRRGDQL PRRQHRFPAV RRERRRDPGA
DRRVEETLRG LRAYRAGVVD HVRGRRARRE NDRAPWSVDG DPRADGGRRL MDDSPTPPGG
FEAPFGGTDT PRIGLGIDNR RNRELLSELL SEYEAVELED RVGSETDLCV VDPGGFDRLA
ADIERWKAEQ RPAAAPALLL ANAPEPAIWD EYADAMGRKL DAVQSTSAPK RAILIRVRGL
LQMRRFSRAA KERHERLELY ERAMDGANVG ITIADADEPD LPLVYINDSF EAITGYGPAE
SLGRNCRFLQ GEGTDQRTVD RVRAALEAEE PVSVEILNYR ADGEPFWNDL KIVPVTDGDG
EVTHFLGFQD DITERRQREI DLEQYEQVMQ SIDDPIVVLD TERCVELSNA AAAELLGEDD
ELAVGTPVSA LFPPGAREDV RRALTDIERS EEPQECQFAL PAADGERQVF QFRFQRERNT
ADRPVARTIV VGRDVTTLRE YQNRLSVLDR VLRHNLQNKL TVIAGNTDLL TDRREELSSE
AIADIADSVD AAVADLLGLT EAARQFHRSI EPGDRAGSDA DLSDLVEEVV TAARRRYPGA
DIEFDAPEPV AATIPSTLRL GLDGIIENAV EYATSSEPHV VVAVLDQPEE NLAEIRVADD
GPGIPDRERE ALRRGGETAL EHLQGLTLWL VSWAVRSVGG EFRINGRDPS GTVVVLRLPR
AEA
//
