ID M1XU47_NATM8 Unreviewed; 583 AA.
AC M1XU47;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Archaeosine synthase {ECO:0000313|EMBL:CCQ37986.1};
GN Name=arcS {ECO:0000313|EMBL:CCQ37986.1};
GN OrderedLocusNames=Nmlp_3874 {ECO:0000313|EMBL:CCQ37986.1};
OS Natronomonas moolapensis (strain DSM 18674 / CECT 7526 / JCM 14361 /
OS 8.8.11).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haloarculaceae; Natronomonas.
OX NCBI_TaxID=268739 {ECO:0000313|EMBL:CCQ37986.1, ECO:0000313|Proteomes:UP000011867};
RN [1] {ECO:0000313|EMBL:CCQ37986.1, ECO:0000313|Proteomes:UP000011867}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18674 / JCM 14361 / 8.8.11
RC {ECO:0000313|Proteomes:UP000011867};
RX PubMed=23516216; DOI=10.1128/genomeA.00095-13;
RA Dyall-Smith M.L., Pfeiffer F., Oberwinkler T., Klee K., Rampp M., Palm P.,
RA Gross K., Schuster S.C., Oesterhelt D.;
RT "Genome of the haloarchaeon Natronomonas moolapensis, a neutrophilic member
RT of a previously haloalkaliphilic genus.";
RL Genome Announc. 1:e0009513-e0009513(2013).
CC -!- PATHWAY: tRNA modification; archaeosine-tRNA biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005030}.
CC -!- SIMILARITY: Belongs to the archaeosine synthase type 1 family.
CC {ECO:0000256|ARBA:ARBA00008906}.
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DR EMBL; HF582854; CCQ37986.1; -; Genomic_DNA.
DR RefSeq; WP_015410713.1; NC_020388.1.
DR AlphaFoldDB; M1XU47; -.
DR STRING; 268739.Nmlp_3874; -.
DR GeneID; 14652121; -.
DR KEGG; nmo:Nmlp_3874; -.
DR eggNOG; arCOG00990; Archaea.
DR HOGENOM; CLU_029831_0_0_2; -.
DR OrthoDB; 115061at2157; -.
DR UniPathway; UPA00393; -.
DR Proteomes; UP000011867; Chromosome.
DR GO; GO:0016763; F:pentosyltransferase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006400; P:tRNA modification; IEA:InterPro.
DR CDD; cd21149; PUA_archaeosine_TGT; 1.
DR Gene3D; 3.10.450.90; ArcTGT, C2 domain; 1.
DR Gene3D; 2.30.130.10; PUA domain; 1.
DR Gene3D; 3.20.20.105; Queuine tRNA-ribosyltransferase-like; 1.
DR Gene3D; 3.40.50.10630; Uracil-DNA glycosylase-like; 1.
DR InterPro; IPR040777; DUF5591.
DR InterPro; IPR002478; PUA.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR036974; PUA_sf.
DR InterPro; IPR036511; TGT-like_sf.
DR InterPro; IPR029402; TGT_C2.
DR InterPro; IPR038250; TGT_C2_sf.
DR InterPro; IPR002616; tRNA_ribo_trans-like.
DR InterPro; IPR036895; Uracil-DNA_glycosylase-like_sf.
DR NCBIfam; NF040592; tRNA_mod_ArcS; 1.
DR PANTHER; PTHR46499:SF2; ARCHAEOSINE SYNTHASE; 1.
DR PANTHER; PTHR46499; QUEUINE TRNA-RIBOSYLTRANSFERASE; 1.
DR Pfam; PF17884; DUF5591; 1.
DR Pfam; PF01472; PUA; 1.
DR Pfam; PF01702; TGT; 1.
DR Pfam; PF14810; TGT_C2; 1.
DR SUPFAM; SSF88802; Pre-PUA domain; 1.
DR SUPFAM; SSF88697; PUA domain-like; 1.
DR SUPFAM; SSF51713; tRNA-guanine transglycosylase; 1.
DR SUPFAM; SSF52141; Uracil-DNA glycosylase-like; 1.
DR PROSITE; PS50890; PUA; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000011867};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 103..238
FT /note="tRNA-guanine(15) transglycosylase-like"
FT /evidence="ECO:0000259|Pfam:PF01702"
FT DOMAIN 283..431
FT /note="DUF5591"
FT /evidence="ECO:0000259|Pfam:PF17884"
FT DOMAIN 446..510
FT /note="tRNA-guanine transglycosylase patch-forming"
FT /evidence="ECO:0000259|Pfam:PF14810"
FT DOMAIN 527..580
FT /note="PUA"
FT /evidence="ECO:0000259|Pfam:PF01472"
SQ SEQUENCE 583 AA; 63314 MW; 67A6B430FA80A07E CRC64;
MTEYFEIHGR DGAARRGELR LPGPLPTPAL ADDVVEDGGS RWHADQSVSA GEASALTILP
HRALPPGTEP PVEDAFGTDP DDVEFPSAAV VSPTTADDYG ADAYVLSNAG GYVGHAEAFV
EALLSLKRSI PDDAALYCPG AATPANVATL AYAGVDLVDE KRARARGLEG FYLTTDGEAF
LEDLEELPCP CPACRSGIDS FDRTDCAEHN ATALAAELAR VRGRIDEGRL RDYVEGQARH
EAWLTATVRR LDQQYGYLEE RTPMFRRNEL LAATDDTLRR PEIQRFAERV TTRYRRRLDA
PVVLLPCSAR KPYSDSQSHE QFARAIGYRG HVVSMTSPIG VVPNELETTY PAQHYDSVVT
GEWTETEIEF VAAVLERYLE RADYDRHIAH VPADYREICE RVEASLGIDF EYTASGHPTT
DESLAALSAA LDGEDTYYKS ERELATVRAI ADFQFGDGGG DAVFGPDATT DGFYPKLRVR
DAEGEHLATM VPQYGTLSLT LAGARAWIES GMPTKRVDID GFVPSGSVLA PGVVDADDAI
RPGDEVVFEG PKAFGVGRAA SHGRAMVEGS RGVAVDVRHC AER
//
