GenomeNet

Database: UniProt
Entry: M2PAB8_9FIRM
LinkDB: M2PAB8_9FIRM
Original site: M2PAB8_9FIRM 
ID   M2PAB8_9FIRM            Unreviewed;       831 AA.
AC   M2PAB8;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 55.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN   ORFNames=HMPREF9943_00465 {ECO:0000313|EMBL:EMD17312.1};
OS   Eggerthia catenaformis OT 569 = DSM 20559.
OC   Bacteria; Bacillota; Erysipelotrichia; Erysipelotrichales;
OC   Coprobacillaceae; Eggerthia.
OX   NCBI_TaxID=999415 {ECO:0000313|EMBL:EMD17312.1, ECO:0000313|Proteomes:UP000011758};
RN   [1] {ECO:0000313|EMBL:EMD17312.1, ECO:0000313|Proteomes:UP000011758}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OT 569 {ECO:0000313|EMBL:EMD17312.1,
RC   ECO:0000313|Proteomes:UP000011758};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Izard J., Blanton J.M.,
RA   Mathney J., Dewhirst F.E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M.,
RA   Haas B., Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.,
RA   Chapman S.B., Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA   Heiman D., Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA   Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA   Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Lactobacillus catenaformis F0143.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC       ECO:0000256|RuleBase:RU003756}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EMD17312.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AGEJ01000008; EMD17312.1; -; Genomic_DNA.
DR   RefSeq; WP_004801666.1; NZ_KB446646.1.
DR   AlphaFoldDB; M2PAB8; -.
DR   STRING; 999415.HMPREF9943_00465; -.
DR   PATRIC; fig|999415.3.peg.460; -.
DR   eggNOG; COG0249; Bacteria.
DR   OrthoDB; 9802448at2; -.
DR   Proteomes; UP000011758; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.1420.10; -; 2.
DR   Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR   Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR01070; mutS1; 1.
DR   PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR   SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR   SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW   Rule:MF_00096};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW   Rule:MF_00096};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW   Rule:MF_00096};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW   Rule:MF_00096};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW   Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000011758}.
FT   DOMAIN          673..689
FT                   /note="DNA mismatch repair proteins mutS family"
FT                   /evidence="ECO:0000259|PROSITE:PS00486"
FT   BINDING         599..606
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   831 AA;  94352 MW;  48F2B1072D767F1F CRC64;
     MSKKEKYSPM MEKYLELKKE YQDAFLFYRL GDFYEMFFDD AIKGSKILSL ALTGKNAGVK
     ERVPMCGIPY HAAESYVETL IKQGYKVAIA EQLTDPKASK GLVERGVVQV VTPGTFMDFH
     INENSNHFIG ALNIFDFAYT LAYADLSTGE FYVLNIEKNE HTLANKIDSL GIKEIVTKVP
     YSCEGVLNSL YEHEELNEDY KKLFDKITDF KQMKTASLLL NYLLETQKRE LDHMQPIDEV
     KSEDYVSMDG ATKKSLELIK GANGEKYGSL LWLLDHTHSA MGGRLMKQWI LQPLLSKELI
     EKRLDNVEVF VDNFIERETI RDMINDIYDL EKLSARIAFG NVNARDLKWI SSSLKVIPEL
     KNNLKALNNP RLNKLASQLT DLSHLTKTID EAIADNPPLQ IREGNIIKDG YNKDLDELRS
     IKSNGRKWIA QFEADEKERT GIKGLKVGYN RVFGYYIEVT KSYLSLIKEE FGYTRKQSLS
     NAERFVTPEL KDMEDKILSA QDRIISLEYE IFGQIRHYIR KDVHLIQDAA KAVAKADVYT
     TLAFLASKNN YVRPLFNQSH QMLIEEGRHP VIEEVIGHQN YISNDIKMNE EHEILLITGP
     NMGGKSTFMR QVTLTVIMAQ MGSFVPARRA SLPLFDQIFT RIGASDDLIS GQSTFMVEMM
     EANNALRYAT KDSLIIFDEI GRGTATFDGM ALAQGILEYI AQHIHAMTLF STHYHELTYM
     NENLGISNVH ACADVSGETI TFLYKIKEGA STQSYGINVA KLAHLPSDVI SRAQVILSSL
     EDNNIEKTLS NTDKVYIRQE SEVEKALSRI NPMALSPLDA LSALIELKKL L
//
DBGET integrated database retrieval system