ID M2Q223_9PSEU Unreviewed; 484 AA.
AC M2Q223;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
GN ORFNames=C791_3937 {ECO:0000313|EMBL:EMD25995.1};
OS Amycolatopsis azurea DSM 43854.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis.
OX NCBI_TaxID=1238180 {ECO:0000313|EMBL:EMD25995.1, ECO:0000313|Proteomes:UP000014137};
RN [1] {ECO:0000313|EMBL:EMD25995.1, ECO:0000313|Proteomes:UP000014137}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43854 {ECO:0000313|EMBL:EMD25995.1,
RC ECO:0000313|Proteomes:UP000014137};
RA Khatri I., Kaur I., Subramanian S., Mayilraj S.;
RT "Genome assembly of Amycolatopsis azurea DSM 43854.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMD25995.1}.
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DR EMBL; ANMG01000038; EMD25995.1; -; Genomic_DNA.
DR RefSeq; WP_005159026.1; NZ_ANMG01000038.1.
DR AlphaFoldDB; M2Q223; -.
DR PATRIC; fig|1238180.3.peg.4269; -.
DR OrthoDB; 9802472at2; -.
DR Proteomes; UP000014137; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1.
DR CDD; cd07971; OBF_DNA_ligase_LigD; 1.
DR Gene3D; 3.30.1490.70; -; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR014144; LigD_PE_domain.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR NCBIfam; TIGR02777; LigD_PE_dom; 1.
DR PANTHER; PTHR39465:SF1; DNA LIGASE D 3'-PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR39465; DNA LIGASE D, 3'-PHOSPHOESTERASE DOMAIN; 1.
DR Pfam; PF04679; DNA_ligase_A_C; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR Pfam; PF13298; LigD_N; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
PE 4: Predicted;
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:EMD25995.1}.
FT DOMAIN 42..140
FT /note="DNA ligase D 3'-phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF13298"
FT DOMAIN 187..359
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|Pfam:PF01068"
FT DOMAIN 381..471
FT /note="DNA ligase ATP-dependent C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04679"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 484 AA; 53999 MW; 15085DC3CAB6FEBF CRC64;
MRWPTMAEKL GDYRRKRRPG RTPEPLPERD GETGSDDLFV IQEHHASSLH WDVRLERDGV
LVSWAVPKGL PMSPDLERLA VHTEDHPMEY LTFEGEIPAG EYGGGTMTIW DTGRYETLHF
NNHKVEVVFH GKRARGKYLF LNVKKDDNDR GWLLKRLDPA EPGRVELPSF IAPMLTKPGR
LPSTGEDAQW AYEFDWSGRR TLIRVSGGRI TAYDDSGDDV TGLYPEFRGL GEQLGATEVF
LDGEIVVFDG GKPSPEGLGH RARATKTSAK RLTARYPAFY LVDDLLHLDG RSCVDSSYVE
RRELLDEIGL AGPHWQVPRY YLGDGGAVAR AAREHGLAGI VAKRADSAYH PGKRTGDWLS
ITGTRVQQVV LGGWRPGGGS RARTFSSLLL GVPHEDGLRY IGNVGVGFAA DELEELSRRL
FRLERKTSPF DSVPDKQARD AHWSRPTIVG EVVFGGWTEA GCLRNPRWRG LLPEVSAEDV
EPNG
//
