ID   M2Q3P8_ENTHI            Unreviewed;       583 AA.
AC   M2Q3P8;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   SubName: Full=Ras guanine nucleotide exchange factor, putative {ECO:0000313|EMBL:EMD44009.1};
GN   ORFNames=EHI5A_061000 {ECO:0000313|EMBL:EMD44009.1};
OS   Entamoeba histolytica KU27.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=885311 {ECO:0000313|EMBL:EMD44009.1, ECO:0000313|Proteomes:UP000011755};
RN   [1] {ECO:0000313|EMBL:EMD44009.1, ECO:0000313|Proteomes:UP000011755}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KU27 {ECO:0000313|EMBL:EMD44009.1,
RC   ECO:0000313|Proteomes:UP000011755};
RA   Hannick L., Zafar N., Lorenzi H., Ali I.A., Petri W.P., Caler E.;
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KB445164; EMD44009.1; -; Genomic_DNA.
DR   AlphaFoldDB; M2Q3P8; -.
DR   EnsemblProtists; EMD44009; EMD44009; EHI5A_061000.
DR   VEuPathDB; AmoebaDB:EHI5A_061000; -.
DR   Proteomes; UP000011755; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR006594; LisH.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF160; RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR C; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS50896; LISH; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168}.
FT   DOMAIN          211..322
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          359..583
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
SQ   SEQUENCE   583 AA;  67693 MW;  CEB6F9959632F831 CRC64;
     MSGLKETQID DVPFVNEVED KKNWEEKVMT NHPEVLQLAE ETRFLEGLKD NWQNTQLKEY
     SLPSFARNLS ENKVVNPDTL PEEEVIALIC QYLKEQKLQE TRIALVKEVL SKHPQYQLLH
     PDSPQFVNYT SDPSLKDALE GMVKLGLTDA DNLFEKLPFE EEDFAKLPDE EYDQHISFHT
     STDTDIPITD ENIVPNNNCE IILEKCSEYP DGIEIPAAMS TNQLILFTMT STDVYLNKFL
     TVYRDFITPI ELLNKFIQIK DQNIEKFKYI ISYWIEHFSS DFTTQMVPLL TELEMPEFTD
     DIIKSKLGKV ASNFDKFNLI LKDHETLKQY FPSCKMDLTE QPQLPNDILS NKLYLKDIDP
     TLIAQALCII DQHLYDSISS SEFVMATGTH ISAVLKFYNI AVEWLRQSLF SERILPDSEK
     ASIGMQKVKE KFMDIWMKLY DNKDFHSMAV FATVFNSADH KKEFQNRFSN RKVDAFTLPT
     MFDSKSCYSN YRKGIDSCVS SKQPFVPFIG IPLHHISSIR CGLDTTIENG KINFLKYNSI
     YNCIEQFNLY KKLPYQFTPV YQIISLILRG MSEVEYMVDT ENN
//