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Database: UniProt
Entry: M2Q618_9FIRM
LinkDB: M2Q618_9FIRM
Original site: M2Q618_9FIRM 
ID   M2Q618_9FIRM            Unreviewed;       444 AA.
AC   M2Q618;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   25-OCT-2017, entry version 34.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=HMPREF9943_00073 {ECO:0000313|EMBL:EMD17641.1};
OS   Eggerthia catenaformis OT 569 = DSM 20559.
OC   Bacteria; Firmicutes; Erysipelotrichia; Erysipelotrichales;
OC   Erysipelotrichaceae; Eggerthia.
OX   NCBI_TaxID=999415 {ECO:0000313|EMBL:EMD17641.1, ECO:0000313|Proteomes:UP000011758};
RN   [1] {ECO:0000313|EMBL:EMD17641.1, ECO:0000313|Proteomes:UP000011758}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OT 569 {ECO:0000313|EMBL:EMD17641.1,
RC   ECO:0000313|Proteomes:UP000011758};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Izard J., Blanton J.M.,
RA   Mathney J., Dewhirst F.E., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA   Berlin A., Chapman S.B., Gearin G., Goldberg J., Griggs A., Gujja S.,
RA   Hansen M., Heiman D., Howarth C., Larimer J., Lui A.,
RA   MacDonald P.J.P., McCowen C., Montmayeur A., Murphy C., Neiman D.,
RA   Pearson M., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA   Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Lactobacillus catenaformis F0143.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EMD17641.1}.
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DR   EMBL; AGEJ01000001; EMD17641.1; -; Genomic_DNA.
DR   RefSeq; WP_004801084.1; NZ_KB446646.1.
DR   EnsemblBacteria; EMD17641; EMD17641; HMPREF9943_00073.
DR   PATRIC; fig|999415.3.peg.74; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000011758; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011758};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011758}.
FT   DOMAIN      134    270       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      352    422       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     142    149       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   444 AA;  51012 MW;  84E556347252A5DC CRC64;
     MNNLEANWSK TLNAFGHTTT DKVVFDSIIT LLKAREITDD HHLIVTAETE YNIGIVSDYK
     DQLEELYNEM YNEAIIIDLM SDERYLLLHQ KENISYDYDD HLNPDFTFSN FVVGNSNRIA
     QNASLAVAMK PGTAYSPLFI YSHSGLGKTH LLNAIGNYIK ENKPGVQVIY CTSEQFVNDY
     VSSIASRTMN DFNYRYRHID VLLIDDIQFI ASKEASSEMF FNIFNSLQNE NKQIVISSDK
     PPKDLKGIEQ RLVSRFTNGL TVSIDTPEFE TSKAILSKKI ELEKVDYPIE ESVLDFIASH
     FNRDVRELEG SLKRLLFYKL VFGINKNVID MEFALEAFKE NYEVSKKNEE ITVDQIKKCV
     AEYYNLTVSQ INSKSRTSNI IVARHIAMYL VRSLIDSISY IQIGKEFGGR DHSTVMKACD
     KVEKNMKKDP NYHKAVEEIK SKMI
//
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