ID   M2Q733_ENTHI            Unreviewed;       680 AA.
AC   M2Q733;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=Dipeptidylpeptidase, putative {ECO:0000313|EMBL:EMD45289.1};
GN   ORFNames=EHI5A_018860 {ECO:0000313|EMBL:EMD45289.1};
OS   Entamoeba histolytica KU27.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=885311 {ECO:0000313|EMBL:EMD45289.1, ECO:0000313|Proteomes:UP000011755};
RN   [1] {ECO:0000313|EMBL:EMD45289.1, ECO:0000313|Proteomes:UP000011755}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KU27 {ECO:0000313|EMBL:EMD45289.1,
RC   ECO:0000313|Proteomes:UP000011755};
RA   Hannick L., Zafar N., Lorenzi H., Ali I.A., Petri W.P., Caler E.;
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KB444841; EMD45289.1; -; Genomic_DNA.
DR   AlphaFoldDB; M2Q733; -.
DR   EnsemblProtists; EMD45289; EMD45289; EHI5A_018860.
DR   VEuPathDB; AmoebaDB:EHI5A_018860; -.
DR   Proteomes; UP000011755; Unassembled WGS sequence.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR011659; PD40.
DR   InterPro; IPR001375; Peptidase_S9.
DR   PANTHER; PTHR42776:SF28; DIPEPTIDYL-PEPTIDASE 5; 1.
DR   PANTHER; PTHR42776; SERINE PEPTIDASE S9 FAMILY MEMBER; 1.
DR   Pfam; PF07676; PD40; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000256|ARBA:ARBA00022825};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT   DOMAIN          469..679
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
SQ   SEQUENCE   680 AA;  79459 MW;  82B97BA3ECDD69DF CRC64;
     MTNISKSNLI IKNRKFTAEA LWSMGRINGY DLFDNKLLYT VSYYDIPKNG SSSHIIIKTL
     NSKEYTDLTS KMRDSNDQLT KNCAQSQTNA IFDKNGRGIL FNSNGKLFEY YFDSEQVEQL
     STGSLDISEF KISPDYSKCL FISSVEHSYK NEDYNDLPLT SGMIFEDLNY RHWDEFNTSL
     PHPFVSKLNN MKFEDHPFDI LENEPYESPL KPFGGIEQLC WSKDSKKIAY TCKKKVGKEY
     ATSTDSDIYV YDTETKTTIN LCKDFEPKNY GFDSNPMYSP SGKKIAWVSM ERDGYESDRS
     RLIIFDLGTK KKSFVSEWFE SNVESFDWIN DCQMVFTGVW HGLTHIYLIE INNDNELVNH
     EQITTGQYDY KSVKWFGNML IVKRQSMIEA DELYELDLKT KEIKQISFEN DFIYTQIDKA
     SVQPKWMKTV DNKDMLVWVI YPPHFDSTKK YPTLLYCQGG PQSAVSQFWS YRWNFLLMAS
     EGYIIIAPNR RGLPGFGMEW LEEISLDYGG LCMKDLLTSV DIMKEESYVD SDRLGCVGAS
     FGGYSVYWLA GHHQKRFKVF IAHDGIFNTE EQYIETEEMW FSQWDMGSAV WEGKEKSKKT
     YENSPHRFVE EWDTPILCIH SEKDYRVVVS QGIAAFNAAR MKGVAAELLY FPDENHWVVK
     AQNGMLWQRT FFRWLRRWLE
//