ID M2Q8D8_ENTHI Unreviewed; 210 AA.
AC M2Q8D8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Kinetochore protein SPC25 {ECO:0000256|RuleBase:RU367150};
GN ORFNames=EHI5A_267300 {ECO:0000313|EMBL:EMD45789.1};
OS Entamoeba histolytica KU27.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=885311 {ECO:0000313|EMBL:EMD45789.1, ECO:0000313|Proteomes:UP000011755};
RN [1] {ECO:0000313|EMBL:EMD45789.1, ECO:0000313|Proteomes:UP000011755}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KU27 {ECO:0000313|EMBL:EMD45789.1,
RC ECO:0000313|Proteomes:UP000011755};
RA Hannick L., Zafar N., Lorenzi H., Ali I.A., Petri W.P., Caler E.;
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC NDC80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity. {ECO:0000256|RuleBase:RU367150}.
CC -!- SUBUNIT: Component of the NDC80 complex.
CC {ECO:0000256|RuleBase:RU367150}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU367150}.
CC Chromosome, centromere, kinetochore {ECO:0000256|RuleBase:RU367150}.
CC -!- SIMILARITY: Belongs to the SPC25 family.
CC {ECO:0000256|ARBA:ARBA00006379, ECO:0000256|RuleBase:RU367150}.
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DR EMBL; KB444708; EMD45789.1; -; Genomic_DNA.
DR AlphaFoldDB; M2Q8D8; -.
DR EnsemblProtists; EMD45789; EMD45789; EHI5A_267300.
DR VEuPathDB; AmoebaDB:EHI5A_267300; -.
DR Proteomes; UP000011755; Unassembled WGS sequence.
DR GO; GO:0031262; C:Ndc80 complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0007059; P:chromosome segregation; IEA:InterPro.
DR Gene3D; 3.30.457.50; Chromosome segregation protein Spc25; 1.
DR InterPro; IPR013255; Spc25_C.
DR Pfam; PF08234; Spindle_Spc25; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|RuleBase:RU367150};
KW Cell division {ECO:0000256|RuleBase:RU367150};
KW Centromere {ECO:0000256|RuleBase:RU367150};
KW Chromosome {ECO:0000256|RuleBase:RU367150};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Kinetochore {ECO:0000256|RuleBase:RU367150};
KW Mitosis {ECO:0000256|RuleBase:RU367150};
KW Nucleus {ECO:0000256|RuleBase:RU367150}.
FT DOMAIN 144..206
FT /note="Chromosome segregation protein Spc25 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08234"
FT REGION 47..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 210 AA; 25764 MW; 9B1B39C555B0046E CRC64;
MEESEKHEIM EKDDYEYLEM MEKREKEYQG EMEEDIKKIE GIIKRIEKKE QEKEGGRNKK
REVEEERTRE EIKEELERRK EVERGIKEKI EEEKKRIEEE IREYREARER KRERIEEGER
ELQENNSLLG QFGIEVEARK EGEKEIVRII FEKMRKYKSG VIEMKIGGGV IRVITCQPEI
KELDRLLDQF YLHHNFMLFL MQVRQGLHIC
//
