ID   M2RAF2_ENTHI            Unreviewed;       925 AA.
AC   M2RAF2;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Orn/Arg/Lys decarboxylase, putative {ECO:0000313|EMBL:EMD46498.1};
GN   ORFNames=EHI5A_089510 {ECO:0000313|EMBL:EMD46498.1};
OS   Entamoeba histolytica KU27.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=885311 {ECO:0000313|EMBL:EMD46498.1, ECO:0000313|Proteomes:UP000011755};
RN   [1] {ECO:0000313|EMBL:EMD46498.1, ECO:0000313|Proteomes:UP000011755}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KU27 {ECO:0000313|EMBL:EMD46498.1,
RC   ECO:0000313|Proteomes:UP000011755};
RA   Hannick L., Zafar N., Lorenzi H., Ali I.A., Petri W.P., Caler E.;
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the Orn/Lys/Arg decarboxylase class-I family.
CC       {ECO:0000256|ARBA:ARBA00010671}.
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DR   EMBL; KB444530; EMD46498.1; -; Genomic_DNA.
DR   AlphaFoldDB; M2RAF2; -.
DR   EnsemblProtists; EMD46498; EMD46498; EHI5A_089510.
DR   VEuPathDB; AmoebaDB:EHI5A_089510; -.
DR   Proteomes; UP000011755; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0016831; F:carboxy-lyase activity; IEA:InterPro.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.2300; -; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.90.100.10; Orn/Lys/Arg decarboxylase, C-terminal domain; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR011193; Orn/lys/arg_de-COase.
DR   InterPro; IPR000310; Orn/Lys/Arg_deCO2ase_major_dom.
DR   InterPro; IPR008286; Prn/Lys/Arg_de-COase_C.
DR   InterPro; IPR036633; Prn/Lys/Arg_de-COase_C_sf.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR45229:SF3; BIODEGRADATIVE ARGININE DECARBOXYLASE; 1.
DR   PANTHER; PTHR45229; CONSTITUTIVE ORNITHINE DECARBOXYLASE; 1.
DR   Pfam; PF01276; OKR_DC_1; 2.
DR   Pfam; PF03711; OKR_DC_1_C; 1.
DR   SUPFAM; SSF55904; Ornithine decarboxylase C-terminal domain; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898}.
FT   DOMAIN          224..454
FT                   /note="Orn/Lys/Arg decarboxylases family 1 pyridoxal-P
FT                   attachment site"
FT                   /evidence="ECO:0000259|Pfam:PF01276"
FT   DOMAIN          492..689
FT                   /note="Orn/Lys/Arg decarboxylases family 1 pyridoxal-P
FT                   attachment site"
FT                   /evidence="ECO:0000259|Pfam:PF01276"
FT   DOMAIN          716..837
FT                   /note="Orn/Lys/Arg decarboxylase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03711"
SQ   SEQUENCE   925 AA;  105074 MW;  D1F7146DF65DF472 CRC64;
     MEPFPTRILV VSGAQEGSAL SRTMKTICDE ISRLGSVPVF VSNWHDAYAE LKETIDISAI
     LVDWDQDYVR CKDAMKKYIM PRHAQIFDHK VLVLPASQRD PFCGSKSPLM KLEAEGYNLV
     VPRSYPQEKI DQLQNVPSYD ELLNFLEKEK LKVVPSPLNV IRSFKSINRK VLIFLYTEKL
     VVERLPIQVL ESIQAYIWKN EETPHFVAKR IVASSYEYVE DILPPFFKAL VKYVHKGKYS
     WHCPGHMGGV AFLRSPPGKF FFDFFGENML AADLCNAVGE LGGLLNHFGP IGDAEKYASK
     VFGSEYTYFV MNGTSTANKM VFQGTAVAGD VIVLDRNSHK SSMQAIMLGN YKPIYVTPVR
     NKYGIIGPIP FSEFNVDSLY KKAQKLPYMS LADIQNDIKL LVLTQCTYDG ICYNVAKVLS
     KLQELDTKNM LFDEAWFPYA HFHPFYASYH SMNKSYFDKL EEDSLFHGSA YIEEDSEDEE
     IHRGPTPSAY KGTIFATQST HKVLAALSQG SMVHVRNSPD PFHFDRFNTY FQANTTTSPQ
     YSLIASLDMS SAIMDVSGES ILDDVLKEVI SFRCAMARVK VEFKESEEGW FFGCWQPKDI
     LSGKKNIYDT SYWVLPPSGP DAWHGFPNIG KNQYLLDPLK VNLLTVDEEA GVEIPACVVV
     KFLAMNGIIM EKMGYYTMLS LFSIGSRRGK SATLVTALTQ FKKLYDSNTQ LKYVFTQEKN
     LEFGNVGLKD FCEMMNPEIK RMQEMENEVY SGKLPEVACI PFKASCALVD NNVEWVPVEQ
     LTGRTSALLV VNYPPGIPTV MPGEVFDKIH TDLMVALAHF GEKWPGYEFE VHGLVCKNGK
     YYIPYYPIPR IVDENTFVRE ITATDHINKS LAEAYLKHLQ ETNQEFDSID ESEEWEDPIG
     VSCMSIMPEG EDTRIYLHEE KEENN
//