ID M2RDM8_ENTHI Unreviewed; 567 AA.
AC M2RDM8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Rho guanine nucleotide exchange factor, putative {ECO:0000313|EMBL:EMD42520.1};
GN ORFNames=EHI5A_019230 {ECO:0000313|EMBL:EMD42520.1};
OS Entamoeba histolytica KU27.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=885311 {ECO:0000313|EMBL:EMD42520.1, ECO:0000313|Proteomes:UP000011755};
RN [1] {ECO:0000313|EMBL:EMD42520.1, ECO:0000313|Proteomes:UP000011755}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KU27 {ECO:0000313|EMBL:EMD42520.1,
RC ECO:0000313|Proteomes:UP000011755};
RA Hannick L., Zafar N., Lorenzi H., Ali I.A., Petri W.P., Caler E.;
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KB445492; EMD42520.1; -; Genomic_DNA.
DR AlphaFoldDB; M2RDM8; -.
DR EnsemblProtists; EMD42520; EMD42520; EHI5A_019230.
DR VEuPathDB; AmoebaDB:EHI5A_019230; -.
DR Proteomes; UP000011755; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF263; GRFA PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
FT DOMAIN 164..350
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 382..491
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 567 AA; 66654 MW; 21A380BB482F4554 CRC64;
MGIFEGEEYE QVVLELTKEE IAVSTVNDLI AIAKHFDEFD LKLSEEQKKK IQGAINERTM
KEKKGEKKEE NKKRLERIQY KYLMDYRNWT ALMFAQFLMY NKVNKKQAFF LATDISPTEF
IEKKEKEEEW TPIKEKMKKE LASTIITRAA RKLGRERINT QMNKRANTIK EIISTEESYI
EQLNTVIKFV LNPIKKESIL SSEQIKLIFS DITTIYSVNE QFLKLIKSFE CQDYANVLIG
QIFNQMGPLF KMYADYCMNY HESDILIRQM EAEHHPFISW YSKQVFENAS PQYKKFKISA
FLITPVQRLP RYKLLLADLL KYTPACHPDH ENVKQALKLI TEVTITVNNN TKKREMFEKM
KEYQMSITNL PEDFKINNGS RELLAEGKVL EIKKKNAKPM ALILFNDLLM VCEYIEKGVF
TKTQKKKLSF NNTLKLLDMS FAEVKENEIE AKGIQVEMCL VLMISKQKFI FSFISTEEKE
KWYEYLSNAI EKEKIKQQQF EARAKTAAME KAEMARNLIQ NKFNTFNAGS MKTRRWKDRG
ASVASMSFAE KYRMAEEIKN NLEAPSE
//
