ID   M2RLX4_ENTHI            Unreviewed;       886 AA.
AC   M2RLX4;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Hyaluronan mediated motility receptor, putative {ECO:0000313|EMBL:EMD45515.1};
GN   ORFNames=EHI5A_180880 {ECO:0000313|EMBL:EMD45515.1};
OS   Entamoeba histolytica KU27.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=885311 {ECO:0000313|EMBL:EMD45515.1, ECO:0000313|Proteomes:UP000011755};
RN   [1] {ECO:0000313|EMBL:EMD45515.1, ECO:0000313|Proteomes:UP000011755}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KU27 {ECO:0000313|EMBL:EMD45515.1,
RC   ECO:0000313|Proteomes:UP000011755};
RA   Hannick L., Zafar N., Lorenzi H., Ali I.A., Petri W.P., Caler E.;
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KB444772; EMD45515.1; -; Genomic_DNA.
DR   AlphaFoldDB; M2RLX4; -.
DR   EnsemblProtists; EMD45515; EMD45515; EHI5A_180880.
DR   VEuPathDB; AmoebaDB:EHI5A_180880; -.
DR   Proteomes; UP000011755; Unassembled WGS sequence.
DR   GO; GO:0022607; P:cellular component assembly; IEA:UniProt.
DR   CDD; cd00174; SH3; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 5.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR15735; FCH AND DOUBLE SH3 DOMAINS PROTEIN; 1.
DR   PANTHER; PTHR15735:SF20; PROTEIN NERVOUS WRECK; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   Pfam; PF07653; SH3_2; 1.
DR   SMART; SM00326; SH3; 5.
DR   SUPFAM; SSF50044; SH3-domain; 4.
DR   PROSITE; PS50002; SH3; 3.
PE   4: Predicted;
KW   Receptor {ECO:0000313|EMBL:EMD45515.1};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          57..119
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          145..205
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          274..333
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          346..379
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          403..431
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          511..554
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          588..607
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          673..739
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          764..818
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        403..419
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        511..542
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        764..786
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        787..815
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   886 AA;  103650 MW;  98096FDA12FF84FF CRC64;
     MEVIGYAPVE TNNANCLLYE KGDVIIVNEM TNTELWKGTC NEKKGLFNIT CATTSMPPLY
     QARVLFDFES KNGECLNVKT GELVYVYEED EENTNGWAYC QVGYRFGYVP IKYLEKVNLA
     KELGGRNRMT RVNRQASMCI QLPTYVPCKV TAKYDYIATY GKDICFRKGD EMICFSTSDN
     RWLLVQHPIY GLGYVPLSYV QCEKSIYHVD IKKYAVILYD YEGDTRFHLK GEVGDIVFVE
     SIIASWAVVH VNDKKYVFPS LYLHIFNSEV EMKISEPMGI VLSSFKGESP NELDVERNAF
     VTLLYREKNG WTLVKQGDKI GYVPTSYLEQ IEEGEAYAMI MKDGEGKRKI KKGESSTKEE
     ETKTKNDNEK KEETESVINN NEEQLKVEDK KDETTIISEN NENNISTEEP NNNIQSESKK
     TENITEETEK VLSENEKEEI IPIKKDDIWK VCHVKKEVCT LKRGNLKIIV KNEDIEICRM
     EKPLNYEYEE GKKRIEETMR VIEEQLKVHE EQEHEQRIAE EERKSEEIKQ KRREEEKKFF
     RQTMQTKKKK QNKKITGFRR GGFARPEQLI DTSQLELTKS LYEESLSTFS QNSPKIDESS
     QGEKKEVMLS PEEKQLKELL NNSETNPEII TGVIKRLIQE NGKLQFQIDE IEESQRNLLK
     VIGVLKEELK RTRESSGTQR RFLAKEKTNE PNDMKKQIEQ LKKELEEERQ KNQQTQQSEP
     KENPEKEYPE NSEEKKEIEE LKLKNLELQK QVEELNNEKE KVINETKKQE DLFNSKTEEK
     EQEISNLKNE ITQLKSELQS LENEPKQSTG DSISQTELKD FEDKIQKKVE ELQIIFNKIQ
     QENKVLQQKT TSRQFEMLKK ETTEKLNQFK DELKIMGRKL SLLSTK
//