ID M2RVA2_ENTHI Unreviewed; 731 AA.
AC M2RVA2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Protein kinase, putative {ECO:0000313|EMBL:EMD42407.1};
GN ORFNames=EHI5A_122090 {ECO:0000313|EMBL:EMD42407.1};
OS Entamoeba histolytica KU27.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=885311 {ECO:0000313|EMBL:EMD42407.1, ECO:0000313|Proteomes:UP000011755};
RN [1] {ECO:0000313|EMBL:EMD42407.1, ECO:0000313|Proteomes:UP000011755}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KU27 {ECO:0000313|EMBL:EMD42407.1,
RC ECO:0000313|Proteomes:UP000011755};
RA Hannick L., Zafar N., Lorenzi H., Ali I.A., Petri W.P., Caler E.;
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00005843}.
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DR EMBL; KB445524; EMD42407.1; -; Genomic_DNA.
DR AlphaFoldDB; M2RVA2; -.
DR EnsemblProtists; EMD42407; EMD42407; EHI5A_122090.
DR VEuPathDB; AmoebaDB:EHI5A_122090; -.
DR Proteomes; UP000011755; Unassembled WGS sequence.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd13999; STKc_MAP3K-like; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR23257:SF703; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE; 1.
DR PANTHER; PTHR23257; SERINE-THREONINE PROTEIN KINASE; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00248; ANK; 5.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:EMD42407.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000313|EMBL:EMD42407.1}.
FT REPEAT 252..286
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 287..319
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 341..405
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 441..718
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 469
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 731 AA; 83855 MW; DED167EE90E2D779 CRC64;
MSKGGSETNL LRIEVLEGQH LFVRENTSGE ATLVISVEKE KKKIKINRKD NPIPGTPNNK
IEIGKIPMGE HEIHFLFTDA EKKQPAKHYR CSVPMTELLP YNTNHVKELE FKNEANAEDE
QKPIFKISMF LFQQRDTKAD KAILKKAGAL LIATNNSDLM LIMSALELPK IDVNMCDKEE
KNTALHIATM KSTNEHILLT LLKDPRIDVN VKNKDDNTPL HYFCLNFSNP NCEEAFSLFQ
QRSANMNAKN KIGETPLHKA VFNKCIRLIL VELLLKAGAE VDATTKNGST AMHYAMYMER
TDLISILLEN NASMEIKNEK GETPLSIVSK SKNQSFQNTV KYFKEVIEYL KGINADTQEI
KMFIHNRLFK WKLKEITAKQ LDKIGIKAIG RQRELMKEFK KIEDIDPAKL SDKSTQIESE
EKEREKLLNN ILSSSKFLYK VEYTELIGTG TSGKVFKGIL EGKIDVAVKT LKAGSLKEVE
EFQHEFGVLS KLDHTNIVKF FGVFQDEHQK MMMVMEYCDR GSLYDVLSKG DLKMKFETLF
DFSEQIAKGL EYLHNKNILH RDLKSLNILV QTKVNEKGQE HLVLKICDFG LSRFNSTDNL
NTLQKLRGTY AYCAPEIYFS QPFTYKSDIF SYGIILWEMT YRTIHQKYQR PYQEFPDIKL
DVQIILKSAT LNLRPTIPAS TPLSLTNLIK QCIIKEQDGR PSSSDILMDI NKMKKEYESN
PSAWDTCIIS N
//
