ID   M2S1U8_ENTHI            Unreviewed;       660 AA.
AC   M2S1U8;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   22-FEB-2023, entry version 42.
DE   SubName: Full=Chaperone protein DNAK, putative {ECO:0000313|EMBL:EMD44797.1};
GN   ORFNames=EHI5A_129050 {ECO:0000313|EMBL:EMD44797.1};
OS   Entamoeba histolytica KU27.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=885311 {ECO:0000313|EMBL:EMD44797.1, ECO:0000313|Proteomes:UP000011755};
RN   [1] {ECO:0000313|EMBL:EMD44797.1, ECO:0000313|Proteomes:UP000011755}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KU27 {ECO:0000313|EMBL:EMD44797.1,
RC   ECO:0000313|Proteomes:UP000011755};
RA   Hannick L., Zafar N., Lorenzi H., Ali I.A., Petri W.P., Caler E.;
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KB444954; EMD44797.1; -; Genomic_DNA.
DR   AlphaFoldDB; M2S1U8; -.
DR   EnsemblProtists; EMD44797; EMD44797; EHI5A_129050.
DR   VEuPathDB; AmoebaDB:EHI5A_129050; -.
DR   Proteomes; UP000011755; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   CDD; cd10170; HSP70_NBD; 1.
DR   Gene3D; 3.30.420.40; -; 3.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR45639:SF4; HSC70CB, ISOFORM G; 1.
DR   PANTHER; PTHR45639; HSC70CB, ISOFORM G-RELATED; 1.
DR   Pfam; PF00012; HSP70; 2.
DR   PRINTS; PR00301; HEATSHOCK70.
DR   SMART; SM00028; TPR; 2.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50005; TPR; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   REPEAT          563..596
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REGION          477..511
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   660 AA;  74790 MW;  78265D1386FAC3A9 CRC64;
     MNFLGIDVGS KHSLIAHTVE GSFPTVVSNK ISNPLTPSCI VYEPASEAVF IGDEAIDKQM
     RYPQHTINNV TTQPTFNQEL PYFYHTLLID NLLKDVEMYL KDKLTELKPE ETVVTLTIPS
     EMEEEKKELY KNIIKGHFNF KEVLTLSDIE AAALCLKTMH SVEKKNVLIV DIGAHHTTAA
     VFSVGETIEC ISKESAIVGG NDFDKKLIEY AERYLLEKQK IDITQPNYIR AFIRTQRAVE
     KARILLSTIP ETNIEIDGIN DGSIMIKLSR ELMQQLIHDE LYKIEEVVKK VVNDGKTKIE
     QVEVIGGTGR APNVVQIIKG VVGEEVRFLN SIDSACSIAL GGAVYAERSQ QNKNKLTEEK
     KNNEIEEKQK EMIKKIDEEM LKATTIIKNR ERKMWILNDI ETKINQYRRY IESKEGNIPE
     NESNALRNLC NEMEDWLNDA QDLGLESLEE AYKAHLIAID SAAPTLKSYL DKKAEEAKNE
     KEKAEKMRAE HIGTGETARK RPEPKTNKEK MEAAEKAKEK GTKAFKDTDW IGAIRMYSSA
     LGHVEAMFDM GPEEIDKCNQ MKLSLYLNLA LCYLKVDKLN KALDNAESAL KIDGKNVKGL
     FRKGMALNGL KKYEEALVAF KQSEEIEHSA ATVSWIKNTE AKIQADKEKE KRLAQKMFGF
//