ID   M2S7P5_ENTHI            Unreviewed;      1056 AA.
AC   M2S7P5;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN   ORFNames=EHI5A_039060 {ECO:0000313|EMBL:EMD47406.1};
OS   Entamoeba histolytica KU27.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=885311 {ECO:0000313|EMBL:EMD47406.1, ECO:0000313|Proteomes:UP000011755};
RN   [1] {ECO:0000313|EMBL:EMD47406.1, ECO:0000313|Proteomes:UP000011755}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KU27 {ECO:0000313|EMBL:EMD47406.1,
RC   ECO:0000313|Proteomes:UP000011755};
RA   Hannick L., Zafar N., Lorenzi H., Ali I.A., Petri W.P., Caler E.;
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KB444326; EMD47406.1; -; Genomic_DNA.
DR   AlphaFoldDB; M2S7P5; -.
DR   EnsemblProtists; EMD47406; EMD47406; EHI5A_039060.
DR   VEuPathDB; AmoebaDB:EHI5A_039060; -.
DR   Proteomes; UP000011755; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   PANTHER; PTHR22829; DEP DOMAIN PROTEIN; 1.
DR   PANTHER; PTHR22829:SF16; DH DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}.
FT   DOMAIN          701..899
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          432..455
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          544..567
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          111..179
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        440..455
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1056 AA;  123910 MW;  62FE59D04635976D CRC64;
     MSEPVTAPSQ PSSLGAFKFW NKKEKEMKDI PDVKKNGLSK EFLWTFILNN DTEYDETRCI
     QQLSEVRKVW SVIGTMSSNK VKKDHQRKTS SFGKDIVQMI QENYKFMNEG KAQWEEAFMK
     MTNTVNQLNE DNEALKEQVR TLKNEKMRHS SIVKKESTLH EIELQLQNLV KLNNQIESKL
     SVISIQQSND SLIQKSINEK VELIEKNINS HTLSKIPSLS FNTIDEEMSL HQIDDNENKT
     KTPELPDHYY TDNSVIPTIP LKNTIVINDY QPSEQTEEKL NHTQNDIVIS SKKTLPIQID
     QFNGCDDFVV HRLDQQPLVS SYENNEHALI LEEDNIPHLG NVPSVQRKTS HVMSRSVGDA
     NFLDEIHQDM STQSTPYRLM KMPLRRYISS SKHNELFISP ATKRSRSILS SQQMTLSHEE
     LTMKVKKPLV RINQSSDNLT PRSKKDHELK EKEEELKQRE EILKKKEEEV SQKEKEVLVV
     QIEIENREEE LQSWEDDIQR RENEIREREG EVRRREVELE QKEEVIQKED ETKQKEIEKI
     EIIKTDPFKG RASEPPKDTS SSKEFEELKK EKLQLEQTIQ DQQLRVWTLE EQNKRVERIV
     KMMDSNEPSE DDITQFIETI KEIVNRKKQK LRFILTQKIV DTFSRYVQNP LSLSAIITPR
     GSIRKSEKKK DKRELQYIQF IPNKIEEKRK TSLIVKDNYE MYRTVCYDFY VKEGEYYRII
     NEFNEVYIKN INWSIMKDFA KEFKELFEPI LMLTKKIVDE LDRAYSDPIK DAEGKSCIAL
     GSILEKYAQT LRVYLNYILR CPYFVDHFPV FSQSKELTDS LVLSITNYIN SQRLNNPSFV
     VNSFLPISAY ILAPVSHFSV YPQLMRELAM NISNNHFDNL AVQNALRIIE GIEDEIDRQK
     NSAERCDAVR FVKTLFVKTI EIPDGHCELL YFGFLKPVDI EKFKVHDDII RVCFLFNTMF
     IITKIKTFQG KVLDKKALTA KFYQEISGLN VEFLKGFILE EVDRCFITDH IIISLIQNIG
     SIINGFTVEF NEKQYNFVAS SQKQQYNWCD AFSNLM
//