ID   M2UDT0_COCH5            Unreviewed;       931 AA.
AC   M2UDT0;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=RNA-dependent RNA polymerase {ECO:0000256|RuleBase:RU363098};
DE            EC=2.7.7.48 {ECO:0000256|RuleBase:RU363098};
GN   ORFNames=COCHEDRAFT_106396 {ECO:0000313|EMBL:EMD96714.1};
OS   Cochliobolus heterostrophus (strain C5 / ATCC 48332 / race O) (Southern
OS   corn leaf blight fungus) (Bipolaris maydis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX   NCBI_TaxID=701091 {ECO:0000313|EMBL:EMD96714.1, ECO:0000313|Proteomes:UP000016936};
RN   [1] {ECO:0000313|EMBL:EMD96714.1, ECO:0000313|Proteomes:UP000016936}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C5 / ATCC 48332 / race O {ECO:0000313|Proteomes:UP000016936};
RX   PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA   Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA   Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA   LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA   Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA   Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA   Grigoriev I.V.;
RT   "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT   genomes of eighteen Dothideomycetes fungi.";
RL   PLoS Pathog. 8:E1003037-E1003037(2012).
RN   [2] {ECO:0000313|Proteomes:UP000016936}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C5 / ATCC 48332 / race O {ECO:0000313|Proteomes:UP000016936};
RX   PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA   Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA   Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA   Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA   LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA   Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT   "Comparative genome structure, secondary metabolite, and effector coding
RT   capacity across Cochliobolus pathogens.";
RL   PLoS Genet. 9:E1003233-E1003233(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517,
CC         ECO:0000256|RuleBase:RU363098};
CC   -!- SIMILARITY: Belongs to the RdRP family. {ECO:0000256|ARBA:ARBA00005762,
CC       ECO:0000256|RuleBase:RU363098}.
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DR   EMBL; KB445569; EMD96714.1; -; Genomic_DNA.
DR   AlphaFoldDB; M2UDT0; -.
DR   eggNOG; KOG0988; Eukaryota.
DR   HOGENOM; CLU_001366_2_0_1; -.
DR   OMA; VDEKKIW; -.
DR   Proteomes; UP000016936; Unassembled WGS sequence.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProt.
DR   InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR   PANTHER; PTHR23079; RNA-DEPENDENT RNA POLYMERASE; 1.
DR   PANTHER; PTHR23079:SF17; RNA-DEPENDENT RNA POLYMERASE; 1.
DR   Pfam; PF05183; RdRP; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU363098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016936};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU363098};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW   ECO:0000256|RuleBase:RU363098};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU363098}.
SQ   SEQUENCE   931 AA;  105839 MW;  35138D3F07EE5F32 CRC64;
     MILNKSSHRI EDELAVVDSK LSAYTPSIPP DFNFAVRYQL AALVLEGTIT PAAMINLIPH
     IQRIAKQYGP EATATAVRRL GQQVPTPAPD VSAETFKVRK FVELTQDNVE DCKHMELASR
     DLNGKQKKHH HLALTYKATV TPTGILLRGP DWDVSNRVLR KYSTRTEYFM RVFFADEDGL
     SVFHDSRASQ NQVYERFRNV LQNGISVAGR TFQFLGFSHA SLRNHQAWFM APFEMDGSLV
     RARNVIQDLG DFSHIHCSAK CAARIGQAFS DTIFSVPVPE TAYVTEVKDD VERNSRTFSD
     GCGTISLELL RTVWRALPPE RRQQRPTVLQ IRYRGAKGVL SLDASLSDQQ LHVRKSMTKY
     IAKETWRDLE LCGAAYKPLS VFLNHQFIKI LEDLGVPAEN FLHVQDEAVN TLKLITEHPL
     NAASFLAYSH SCIFAKVPQL FEMMHRIGLP FHADRFLTDI VEVAAMSSLR SLKYRARIPI
     EKGYLLYGVM DETNTLKYGE VYIATQDHDK TGKLKRSILV GNQIIVTRAP ALHPGDIQLV
     DAVDVTDDSP LRALHNCIVF SQQGPRDLPS QLSGGDLDGD LFHIIYDQRL IPAYTVEPAE
     YDKAPAKDLG RPVEANDIVG FFIEYMKMDR LGQISNKHKI RADVKPNGTR HPDCLTLAKL
     ASDAVDFSKT GVPADMSRIP KGIDHFRPDF MAPGSHLVIN ELGAAELAEL EEDDIDDPDS
     ISVLDADKGR IRYYRSDKIL GILYRAIDEK KFFDKMKSDY EIFRQRWGKE SLVDKLKRYI
     IRETQGLQWE HHWDFAEQLR ETYEENMLEI MDTLRPTRGQ PLTELEVFSG NILSKKERAP
     SRYIREANLE VQERFNRDVS SIIKTIVHGD KDWDSEENAA EALPRSIACF MVALEVKGWE
     NYRSLQSWKY VAASVCLEQL WKYNGGTLRC L
//