ID M2UQQ3_COCH5 Unreviewed; 2274 AA.
AC M2UQQ3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EMD90232.1};
GN ORFNames=COCHEDRAFT_1104189 {ECO:0000313|EMBL:EMD90232.1};
OS Cochliobolus heterostrophus (strain C5 / ATCC 48332 / race O) (Southern
OS corn leaf blight fungus) (Bipolaris maydis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX NCBI_TaxID=701091 {ECO:0000313|EMBL:EMD90232.1, ECO:0000313|Proteomes:UP000016936};
RN [1] {ECO:0000313|EMBL:EMD90232.1, ECO:0000313|Proteomes:UP000016936}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C5 / ATCC 48332 / race O {ECO:0000313|Proteomes:UP000016936};
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
RN [2] {ECO:0000313|Proteomes:UP000016936}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C5 / ATCC 48332 / race O {ECO:0000313|Proteomes:UP000016936};
RX PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT "Comparative genome structure, secondary metabolite, and effector coding
RT capacity across Cochliobolus pathogens.";
RL PLoS Genet. 9:E1003233-E1003233(2013).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB445578; EMD90232.1; -; Genomic_DNA.
DR STRING; 701091.M2UQQ3; -.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_31_0_1; -.
DR OMA; PNVYPER; -.
DR Proteomes; UP000016936; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775:SF53; ATROCHRYSONE CARBOXYLIC ACID SYNTHASE-RELATED; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000016936};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 20..445
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2188..2265
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 478..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2274 AA; 249058 MW; F38C67231D67863D CRC64;
MKLSTTQRDS QSASPDKKSF EPIAVVGFGF KFPQDVTNAE TLWKLLIERR STMTEIPKNR
WNIDGFYKEN GHRPGTVKNR GGHFLSDDPA RFDAPFFSIQ PAEAECMDPQ QRLLLETSYH
ALENAGITMQ DAVGTRTSVH VGCLLQEYSQ ISQRDAQMPG DYRIVGSSGL AMLSNRLSWF
YDFSGPSMTV DTACSGGLVA LHLACQELLA GSVNMSLVCG TNLCLLPDST ALLSSLNMMS
KDSVCYSFDE RASGYARGEG FGVLVLKRLS EAIADGNNIR GVIRSTGCGQ DGNTPSITSP
SQSAQERLIR ETYARAGLSL DETRYFEAHG TGTKAGDPCE AAAINSVFSA RTPEDPIFVG
ALKSNMGHPE GASGIAGVIK TLLVLEKGII PPNVYPERIN PAVTAAGPNL RFPLEPVTWP
TSGVRRASVN SFGYGGTNAH VVIDDALSFL REQGLEGRHC TADVRTIEEA KYVHPCNTST
LSRTSSNENG SEIMPSGSTA RDDTPSGSIG DYEEASPSAS ENSKFTPKLL AISAFDERAV
HRSIDALKKW MNDYMEDENR RPTLNDIAYT LAEKRTKFPW KSTCVALSET QSELTWSPPV
RSKPNTNMCF VFTGQGAQWY GMGRELMQYD VFSKTMREAD RYFQSLGSSW SLIDELCNKS
ESESAIHKPE LSQPICTALQ VAIVDLLTSW KIRASVSVGH SSGEIAAAYA SHAISRESAW
MVAYFRGLAV SITQSLSPSN GAMVAVQAPL DAWKHLMDKQ NESHAEDPIV IACYNSLRSF
TLSGPRNAIH QLSSTLKKAN IEVHILKVDV AYHSHHMKPV AGIYDKLLRK IEAGEPLDDQ
PSFVSTVTGK PLDQLAELRT AAYWNRNLTG SVRFSIALEG ICARPDASSC YFVEIGPHSA
LRSPLSDILK VAGRDVKSEY VSVLRRDHTA DVTAMQCAGK LHTIGTSVDI SAVNNIRGSD
SKILTSLPSY QFEDKKRYWL EGRTSIQYRQ TKFVHHELLG SRTPDWNELE ARWTNRILLD
QSPYLKDHVI NGLCLMPAAG MLVMAIEAVR QFYGDAGADA SGYRMKDVSF TRPMTLSENP
RGTEIQLTLR PGSVDVRDTK PGSSWSHFSL YVYENDTWHL CCSGSILIAY DNPRETSAEQ
TERVEKFITT TKQCRTDISH EEIYNAFNKA GLSYGPTFRS MHAVKWDEQS QQATGSINLA
EWQKHARFTY TDAHLIHPAA LDTILQMTFP AYSIFARNAS ATTVPTGFTN AWFSADLLRA
SNEAKSVKVN AQVKGCGFRN KLFDVTAVAE QDRELYFYGE LETSTIGRSG AAADEGEAAP
TLYRIDWQPA NFSDLTLEER ESLYSGSTVY VVYDECDSLQ SNLAEMLGKV ALSHCDTSFI
PTSWSSVSEN DLSKATCVFL PGLDGTLLRL MQDDDLNKIK QLFSTADALI WPTLQHLALD
QSPTEGLVSG LVRTLATESE DYHLISVSLN RENGLEKLAS NILAVLDAKL ADQTSDPEDE
YWEIDGVLCT PRVVDDAELA ATVLPPSKEV ATTVSKPWSE LKNPVLTIGA AGILNTLHYE
QDGTQCNALG SDDVLVQVKA VGLNTRDVQV ALGQIHDNAF GSEIAGVVLQ TGSRSASHFQ
PGDRVFGITR NGVAQTAVSS FKQLRKIPGE MRFSETLSFA EAAAIPVAFC TAYFALMQVA
GVKLDDNVLI HDATSALGHA AIRMCIHQGC RDVFTVVESE EQLDRMLQHG PVSRSSIFVT
GDANLEHKIR RETEGRGVDV ILGSAGALRS SSGCIASFGC MVDIGEKHAF VSTASRPKEN
GLPAVVANKN VTFANINFQE LAKSHLFEGI FDNVCQMIAD DRIIPQVPLA VFKQSEVEKA
FRAVQDNDTM AKVVIEMDDD EVVDMEVASS PSKLLFHEDA SYLVAGAFGG IGQSIVKWMV
QQGARYLILP SRSPVGGTGS DREHFIQELQ EQGAIVKAPV CDIADKHQLQ DMLDSIRDFP
NIRGCIQAAM VMRDSSFANM SVEKWHQSLA PKVDGSWNLH QLLPRDLDFF VMLSSSTGIM
GSFGQSNYTV GNTYQDALAA HRMRHGQRAH TLALSMVTGV GYVAQNEQVQ ALLRVRGMLE
EVSTQDIFSL LHFCCDPRRV DSSSVGSQII TPLTLPADLR AMGIVAPLGS TRPIYHYLDT
LPARISSTAE TDKSRPSHLL SEAKSLAQAT DIIVGAIQVQ LSSLLVVSKD DIDPQKAIYR
YGVDSLVAVE MRNWFSKAVG ADVATADIMS DISIWLLAVK VAGTSRFVRD ELKE
//
