ID M2WA66_GALSU Unreviewed; 521 AA.
AC M2WA66;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=shikimate dehydrogenase (NADP(+)) {ECO:0000256|ARBA:ARBA00012962};
DE EC=1.1.1.25 {ECO:0000256|ARBA:ARBA00012962};
GN ORFNames=Gasu_01510 {ECO:0000313|EMBL:EME32791.1};
OS Galdieria sulphuraria (Red alga).
OC Eukaryota; Rhodophyta; Bangiophyceae; Galdieriales; Galdieriaceae;
OC Galdieria.
OX NCBI_TaxID=130081 {ECO:0000313|EMBL:EME32791.1, ECO:0000313|Proteomes:UP000030680};
RN [1] {ECO:0000313|Proteomes:UP000030680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=074W {ECO:0000313|Proteomes:UP000030680};
RX PubMed=23471408; DOI=10.1126/science.1231707;
RA Schonknecht G., Chen W.H., Ternes C.M., Barbier G.G., Shrestha R.P.,
RA Stanke M., Brautigam A., Baker B.J., Banfield J.F., Garavito R.M., Carr K.,
RA Wilkerson C., Rensing S.A., Gagneul D., Dickenson N.E., Oesterhelt C.,
RA Lercher M.J., Weber A.P.;
RT "Gene transfer from bacteria and archaea facilitated evolution of an
RT extremophilic eukaryote.";
RL Science 339:1207-1210(2013).
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DR EMBL; KB454484; EME32791.1; -; Genomic_DNA.
DR RefSeq; XP_005709311.1; XM_005709254.1.
DR AlphaFoldDB; M2WA66; -.
DR STRING; 130081.M2WA66; -.
DR EnsemblPlants; EME32791; EME32791; Gasu_01510.
DR GeneID; 17091341; -.
DR Gramene; EME32791; EME32791; Gasu_01510.
DR KEGG; gsl:Gasu_01510; -.
DR eggNOG; KOG0692; Eukaryota.
DR OMA; KNSAMVC; -.
DR OrthoDB; 1308at2759; -.
DR UniPathway; UPA00053; UER00087.
DR Proteomes; UP000030680; Unassembled WGS sequence.
DR GO; GO:0003855; F:3-dehydroquinate dehydratase activity; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0004764; F:shikimate 3-dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019632; P:shikimate metabolic process; IEA:InterPro.
DR CDD; cd00502; DHQase_I; 1.
DR CDD; cd01065; NAD_bind_Shikimate_DH; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR HAMAP; MF_00214; AroD; 1.
DR HAMAP; MF_00222; Shikimate_DH_AroE; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR001381; DHquinase_I.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR041121; SDH_C.
DR InterPro; IPR011342; Shikimate_DH.
DR InterPro; IPR013708; Shikimate_DH-bd_N.
DR InterPro; IPR022893; Shikimate_DH_fam.
DR InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR NCBIfam; TIGR01093; aroD; 1.
DR NCBIfam; TIGR00507; aroE; 1.
DR PANTHER; PTHR21089:SF1; BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR21089; SHIKIMATE DEHYDROGENASE; 1.
DR Pfam; PF01487; DHquinase_I; 1.
DR Pfam; PF18317; SDH_C; 1.
DR Pfam; PF01488; Shikimate_DH; 1.
DR Pfam; PF08501; Shikimate_dh_N; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Lyase {ECO:0000313|EMBL:EME32791.1}; NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000313|EMBL:EME32791.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030680}.
FT DOMAIN 231..310
FT /note="Shikimate dehydrogenase substrate binding N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF08501"
FT DOMAIN 361..431
FT /note="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA
FT reductase"
FT /evidence="ECO:0000259|Pfam:PF01488"
FT DOMAIN 483..513
FT /note="SDH C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18317"
SQ SEQUENCE 521 AA; 58013 MW; 7D428FB65CA3519F CRC64;
MSGCLLCVPI TAQYVKEAFE QIKEAQRLGA DLVELRLDLL DSTEEWEDLV KHCFVPKIAT
CRPHWEGGNY NGSESRRLSI LSEACKLGCE YVDVELEAIT RFEKPSNCHT KLILSRHLWN
RPFSHQELAN TYSSMLSNQA DVIKVACKID NIEQCEILFH FIAASKVPCI ALGMGEAGQI
SRILAGRYGA FLTFASLSKG KESAPGQIEL NDCIQMYRLK SLSSSTKLYG VVGNPVAHSM
SPAIHNLAFA SLSLDCVYCP LAVEDFGSCW KMLNEMGFMG LSVTIPHKET AKRYVDELDG
LALKIGAINT MVKLERGWKG YNTDCLAAVS AIEDGLIAQR SSSELSHRTN SFSTQAGAKP
LVLILGAGGA ARAIAFGLLE RSYNIYVVNR NYDRCKKLAA ELGIEAIPWE GLRRFLLEHK
DSIDVIIQST SIGMHPNVHD TPLSFDDLQS LSKKPLVFDV VYNPVETRFL REAREVGCYV
VSGLEMFVRQ AVYQFELWTG SKAPVEQMRQ VVLKRLKTFM E
//
