ID M2WX92_GALSU Unreviewed; 5016 AA.
AC M2WX92;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN ORFNames=Gasu_38580 {ECO:0000313|EMBL:EME28650.1};
OS Galdieria sulphuraria (Red alga).
OC Eukaryota; Rhodophyta; Bangiophyceae; Galdieriales; Galdieriaceae;
OC Galdieria.
OX NCBI_TaxID=130081 {ECO:0000313|EMBL:EME28650.1, ECO:0000313|Proteomes:UP000030680};
RN [1] {ECO:0000313|Proteomes:UP000030680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=074W {ECO:0000313|Proteomes:UP000030680};
RX PubMed=23471408; DOI=10.1126/science.1231707;
RA Schonknecht G., Chen W.H., Ternes C.M., Barbier G.G., Shrestha R.P.,
RA Stanke M., Brautigam A., Baker B.J., Banfield J.F., Garavito R.M., Carr K.,
RA Wilkerson C., Rensing S.A., Gagneul D., Dickenson N.E., Oesterhelt C.,
RA Lercher M.J., Weber A.P.;
RT "Gene transfer from bacteria and archaea facilitated evolution of an
RT extremophilic eukaryote.";
RL Science 339:1207-1210(2013).
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}. Plastid, chloroplast
CC {ECO:0000256|ARBA:ARBA00004229}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
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DR EMBL; KB454517; EME28650.1; -; Genomic_DNA.
DR RefSeq; XP_005705170.1; XM_005705113.1.
DR STRING; 130081.M2WX92; -.
DR EnsemblPlants; EME28650; EME28650; Gasu_38580.
DR GeneID; 17087505; -.
DR Gramene; EME28650; EME28650; Gasu_38580.
DR KEGG; gsl:Gasu_38580; -.
DR eggNOG; KOG1808; Eukaryota.
DR OrthoDB; 1221059at2759; -.
DR Proteomes; UP000030680; Unassembled WGS sequence.
DR GO; GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF3; -; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 6.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 1.
DR PIRSF; PIRSF010340; Midasin; 4.
DR SMART; SM00382; AAA; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|PIRNR:PIRNR010340};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR010340};
KW Reference proteome {ECO:0000313|Proteomes:UP000030680}.
FT DOMAIN 4803..4999
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 4237..4512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4243..4269
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4270..4291
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4296..4319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4321..4384
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4409..4423
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4455..4473
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4474..4512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5016 AA; 584408 MW; CB60E0E8FDF249C8 CRC64;
MNVVEAISSG WARMMASRYD RYLKAIVVSN NANENLKDLA KDRSWKEFVT SSIESFLQVF
EKDKTSFYEA LSCLQVPELV EVFAVTLHLF RHCRNKLSKR RQKLFGVLVR VSIVSGKHSQ
LFQLFLYLAR RNCFVGLWSE YSGRAETSLG DICAVRRELA LIAYYWNSYD LNGLFPWECI
IQAAASGDKE AKIVFSWLFN NSDCLESERW TGLNSDWSVW KELDLLEYTK RCILLNISLE
KVVDTVDCEH VSGPLEFRCS PELGLSHVCD FPLISPHIIF NNDILMGDKR FVVSNFVLLE
HFIPVIYDCL ECIAMGIPVM LEGPAGSGKS ALLQLLSQIR EQREVIYSHD MDEKKLSLPQ
TITLCMSGCR GFEDFDELVG NIVPHAESEG FVWKAGPIGV AIEGGHWLVL EDLHNTSNAT
CYGIERLVEL RAGEKLEVSG RKRPLEAAFG FHLFGVRTCD DNCCDTNEQH SYECQSSWEP
PGGSWKWKRI HLPNLLQNER DGRLYKILQS RFPCLSFCHH RLASTIFELL RIYREKILSR
LCRPATLTDL IRICTRLEYL QLRGEILSTE MAVCECLDVL CSWDPDKNRR SRVYSVLSEA
WSIPFDTVKY FDIIVRPQWN TTSQVTGITR LGRAQWTNEN NINIFQATIK VSNGCSWMSH
TLRLWERIAR CVEMKEPVLL CGETGTGKTS AIQEMAKMMG VSVVVLNLSP QTEWNDLIGT
YRPHHPFQDV QHLSQLFLDA FCPSFGTERN QTFLHNLDSA LKNKDIDRCY RLIVGAWKKI
EQSVSLASLE SSRHEKWNIF REYLSQFKKV YGDTESNFHL KKRKRKDALE WNEGSSRNNN
SITFRFQAGP LISAMKEGHW ILLDEINLAP FEILEELSML LERGMLPVLN DISSCENRDM
AENTYLKAHP NFRIFAAMNP PTDVGKRDLR LSIRKKFTEI YVDENLEEED LIILISKRYF
GRSREDCTDE EYCIVQDVVR FYLSSRKLCE NQYLVDANGR KPHYSLRALC RTLDLAQCIY
CRMKSVGSAW MRHKRALYEG ASLSFISPLP FSCRSFIEKL ADEIFLAGNS LRDKKMSELV
KVPTSLSDGY CFIEMEGYWL LSQHSTHLDH YRNSLKSSKV SVDEGDNQFI TTPSVKHTMR
DILRTLQYGV PKYAVLLQGP TASGKTSLVS YLARTTGQTL LRINHHEHMD LSEYLGSFQM
DDTGSFHFVQ GPLLKAVRLG FWVVLDELNL APNELLEALN RLLDDNREIY VPELAQTFRA
HENFVLFATQ NPSGEYAGRK QLSRAFRGRF IELNVGELPM EELNVILQRR YRLPLSFTER
MIRVMHELQV QRTRERVFLG KESLISARDL FRWASRSPDS KESLAKEGFF LLGERCRTTE
SREFIRKVLI DSIGVSSEVL KDEHLYEEEQ NNEKWMPVLA KLNLVPTPSL FRMIALVKRA
FEHQESVLLI GETGIGKTTC IQVLAEYENN FLWTVSCHRH LDVSDFIGAF RPRRKSDSSK
LFEWVDGPLV SAMKGGNYFL LDEVNMASDA VIERLNSVLE PERTLTEYKS CCSTQDSSHS
SSHNLTAHSQ FCFVAAMNPA SDYGKKECSI AFRSRLTEIW VPPNNAVEEY VGFIANAWSK
QSPLHVYVKP MQELVICVLN DMDSSPPLER QLLYSMFTWR DIRAWMHFIE SSREIFQHPF
SSYAHGFDLI LLDGLKVSSL SHSSHLERLV EKWKTLLLKQ CQERMCFEEI QQELYIQGLS
KQTIPIREEE EAYRFGNLKL NKVNADIESD QQNILSVVSL ETDTMRRNSF RIVRAMLLKK
PILLQGPPGI GKTSMIQALA SLCGQRLLRV NLSEHTEMSD LIGMDVPSNH QNDESNAPFV
FRPGPLLVAL QRGYWILLDE LNLAPQTVLE GLNSLLDHRR SIYVAELDKE FYADDQPHFM
LFATQNPAVD GSGRKQLPRS FLSRFTRVAM EQLHLEDMCQ IAEKRFPKLN RSFIRKGLQV
LGNIQQCRKE NEPQELTASN METREHMKLL LSGQDLNLRD ILRWFSCVEE HVELIGDFDV
ASYLFFENLI IERLGMDVHD LAMEKYGQVF DTPTSIQQKI PSFTIYRKDK YLIQAGPVEI
VWHKDWSEEE ESLATFSRTR EEVRWMETYR KSSWTLSIGV LHDWPMIVIG KRGSGRKSLI
RTLSNIFGMK VIVFIFDFVN FCIGQRLVEW NQSGMDTDGG NFVGSYQVFD AWETLWDILQ
VDVISRCNQI LGAIFVEEKQ QEKIVKDLYF VSKWVRELCL ELHNKGSNKF DWMDYELTKV
IGFFDQLSKD VMNPKILHWI VSLRRKLEEC LHIHKNDKKC VSMFQWVYSS FIKAARRGDW
IMIDEAHRYP PAILDALNPF LEDSVSGTNR TLWLPSTVDG EERESFHIHP RFRIFFVVEQ
GKQHQLSKAL WNRALITHLP DLTGSEMNNV TTINNMTNPL TLKDVFKLSC NSIERSVFSC
SSFSYPEENI VHMTYYWWTM MSRRKSWPDL KDIGSDRRWS CIFGLLHSMG KPSYLGIPED
SLLAQVYWIC IDKEDSLSPT EEYQWLQQWL ESKMPHKYQN SDKLVLLKKY PVLCLSEFFL
QMSVWATYYS NYERWMPLVT QFVEFYRCHI VEERYLSLVN SMSNFVTQSP QRESMSYCMS
RDEMIGWLVK EGIVYLPQVL RGEYVVMENE NFLNQTVLLL EYLWDVEMVK KMDTSSLPFF
TVGYWTLIQC IYGYPNEVEP IVMLSLFSFL QQALKELLLA SGAFQEIISQ ERVRDWLHQC
DQVLLSVGGW KLQFLQSYHL FEPLYVSKRM QEANIGSLEY LDSQNAKAIS RQYQVQFRTW
LRSQQVLDAD VDIPSEWLSS LSVDFFESIL IPYENELVFI CQETRMVFTI WHFWTSILFW
NGALESCSKQ LPIEWLNMVS TFPSSDWNME CLISQQQLIW LFDCNSKSRV KWQQAWIQHF
LAQGSLSVIL WLFQNRNSFH RMSCLENGWM YLLSSSLRCD WQRSICIENN IYSLNALGYS
LQLHHSKQFL NQMLDIICSL RDERVFQPHD LFVKMYNVQV ELWKQTYLND SSDMQSFQSA
DFNFHICEEA NRSLFSIGEK WFMMGRQHLE ECVLFRSKYH PRKVGQSIQS WKQVLEEMSY
FRFFHFLQDE SYISLWQCFC ENILSTSCNL ASYSDLVEEY PQLVQAFLSM ASDLLSSQRL
DYYQHEIWKL GKKGMEGKDI SSVLQELNQW QTNLSHGLIQ LSEVSKDWGL IDQVLVAGYE
ILVGSYLMTR DFYFQLPIGG CGDVSDNVPS PICPISSLPS KCVAWSLQYE NSNFNLSISQ
LMTLKWLYFL RMEPVVSQVT IHGISQVHKY LGQIIGHFGL RSHFVQPNEM NQAPISWNFQ
EKAEDVWFDE ESRESWDKLY LQAHLLEDMT SEHSWESSKQ QLEKSKRHIW FIQLIIGLLT
QWSPQQSSSC KQQLQRIYSF ANCAARQESR QEDIKDDPSR LINEFDYWDL GGWILLFGME
GEITPMDSTQ VLRKSCFQFY QDLMPNEIVQ LDEPWKQTYK FVKQYHQSTE HLAYKSLLNT
VEEDLVRIQQ LSRKTPMIRI AQLVKQWKDH LILWQKQWLG KEHPIGKVIA QLQCILDKWN
KWIMQHWQKE WIEWREEKLQ MDSIDYFLPL YIFLSHSLQS SVCREDVMQV MDFFLRTAQI
ADFSLRVNIV KSFYLLFQWK KDDSTTSWLA NLLRGIYCYY QQYERRIQKD YEERRKTALD
KIQRNIEYAY QYSQTSAEEL ESRFGFPIGL RQKAVQIGRE LERSLSDSIA PLLKDDMENG
YQRDSRAKQL SANLFESLSN REIWHRDWDD VMSFSWCEKT SYLLNVWKKS FHVWEQSLTK
EGFSPQDFQH WLCVLKENEV SCYPSTIPTS HRSLSFQLAC PVIGIKESLD GWDSLEAISL
QDELYFSCLA QSCWIRRWLS YLPELNGQDV LSGDRKQVWN EMNMGLHFGK YLQYMTMQLR
QLIHDVRDGW RNLNKLDEIK DSSLTQFYVQ YTEWITLYEE YNKMRQQPLD KDKEHWFSQL
QQAVEEWYTK QSDSSSLDRL LKVPLERKWK QGIFMYVESL ANLWYKSMHS VKERKDCHDD
TESSRNEHLE RLRNVLDNGA SHSSSLYGVC QNCLVALESM KKQIHSFWDS NRTPEADEAK
DLQIMVSKVI RVAVICDAIC CLWWKLTNDM LFTGIKEKWT QSENDTESTM DREYGTKYEN
VQGTGLCDAS IQSMQEANDI SDQLDEQDWQ EAYEKLGSDK QDKDSQPQTN PMSNHDDSQQ
SQVDMDNTWQ DGTLEEENEE QVEDVESGDG ENDPIISDNL ETSGLESKDS PQQARPSTEE
MLMDNEMKGS NHDDDDLNQE FLTENEKISE LKEEYLESTN GEFADDRNEA QMEEEGHCAE
EMDAFPEDLE NLSESSTVQE EEQQPTEETR EDELQSHDDE SMEMESNTCD DTNWQQQEDK
GEAKDDSCQQ ETGFVSSKED RKPSDHHNKL TPSDHVEANQ ALDNLSEQGE EGQESDQANP
YRSSNNTKGE DANWILNPYM KSSKDIWKHL LERLDMSSNN EDVKMENVVD NGEHQEMDSL
QDMNLNEEEE LSALNPLNES NEVVDSWERS QLNEFIEEGI KKEEEERKAQ VSFEKSSGVC
LREEANANET QSLRTNWEEY EKKQPNEEIE RDLSSLQSNC TKELQDKNTN NAMQLYAPPG
ELAELNSMQV TQELETTASL DEEEDSYVDF TRRVQSFFTR STTGEKESQL IWQQLLQKTS
QDAMLLAERL QMILEPCVTS QLTGSYRTGK RLSMKKVIEF YASDFRKDRI WLRRVQPDRR
SYDVLIAIDD SASMMESQAS ILAMETLALL ASSFTRYEVG RLAVARFGNE VSWLRSFEDS
LSMEVGGAEI LQQFHFKQNA TDVAELLRQA IVFLKESKST SQASIATIQL FFIVSDGRLQ
NRNFIRKLVR EAWENGQLIV FLLTDYVDSK QQSIISLKRV ETLENGELKI SSYLDDFPFP
FYILVRQVES LPQVVASALQ EWIEMMNPSR LGSLDK
//