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Database: UniProt
Entry: M2X2W4_GALSU
LinkDB: M2X2W4_GALSU
Original site: M2X2W4_GALSU 
ID   M2X2W4_GALSU            Unreviewed;       846 AA.
AC   M2X2W4;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   07-JUN-2017, entry version 19.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=Gasu_19610 {ECO:0000313|EMBL:EME30720.1};
OS   Galdieria sulphuraria (Red alga).
OC   Eukaryota; Rhodophyta; Bangiophyceae; Cyanidiales; Cyanidiaceae;
OC   Galdieria.
OX   NCBI_TaxID=130081 {ECO:0000313|EMBL:EME30720.1, ECO:0000313|Proteomes:UP000030680};
RN   [1] {ECO:0000313|Proteomes:UP000030680}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=074W {ECO:0000313|Proteomes:UP000030680};
RX   PubMed=23471408; DOI=10.1126/science.1231707;
RA   Schonknecht G., Chen W.H., Ternes C.M., Barbier G.G., Shrestha R.P.,
RA   Stanke M., Brautigam A., Baker B.J., Banfield J.F., Garavito R.M.,
RA   Carr K., Wilkerson C., Rensing S.A., Gagneul D., Dickenson N.E.,
RA   Oesterhelt C., Lercher M.J., Weber A.P.;
RT   "Gene transfer from bacteria and archaea facilitated evolution of an
RT   extremophilic eukaryote.";
RL   Science 339:1207-1210(2013).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; KB454497; EME30720.1; -; Genomic_DNA.
DR   RefSeq; XP_005707240.1; XM_005707183.1.
DR   EnsemblPlants; EME30720; EME30720; Gasu_19610.
DR   GeneID; 17089428; -.
DR   Gramene; EME30720; EME30720; Gasu_19610.
DR   KEGG; gsl:Gasu_19610; -.
DR   KO; K02154; -.
DR   OMA; WTAYDAH; -.
DR   Proteomes; UP000030680; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000030680};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Hydrolase {ECO:0000313|EMBL:EME30720.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030680};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    415    440       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    461    488       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    545    565       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    577    598       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    646    664       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    785    806       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   846 AA;  97121 MW;  65B594C9CF29CF65 CRC64;
     MTCLFRSVEM VKVRLFIDRS AARATLEGIG EHGLLQLEDL NQNKSEFQRS FSSGIRQCLE
     MQRKLRALEV DVRECFPSRS FNNNDSVSRE ELNSITLDEL DRHLSNLEET VQEMNMHWKS
     LNSHRQQLLE HHYVLVLGSH LFRPGYLSLM SEESSHVNGN ASSMNVKLKP NYTPVDMETT
     FLRLIAGVIS LPALPLFQRL VFRIARGNCL CRFSEIEEVF YDEEKKENVR SSVFVIFCPG
     KELGLKIQKL CEAFGAHLYH LPDDEITRRS LLAQVSNRLQ DIETVVGTTH SQRLQTLSEI
     GAKLALWSEK VLREKAIFHC MNMLNYDTSR NIYIAEGWTP KDELEQLESL LHEGCRLSRA
     QVSSVLEHHV SDNVPPTYFR TNKFTVVFQN IVESYGVASY RELNPACFTI ITFPFLFAVM
     FGDVGHGLLM CLFALYLILF EKKLGRKTLN EILQFCYDGR YIILLMGIFS LYTGLIYNEF
     FGVAMNLFGS RWKFNSSSNF ACGIDNCVDS SQSLPPRNIY PIGFDPIWSQ ASNGLTFFNS
     YKMKLSIVLG VFQMVMGIFL SYLNARYFQR SLDIYHVFLP QMIFMNAIFG YLVIIIFVKW
     SINWNSTSCQ SNPSCSPPDL KQILIGMFMN PGYLPLDMQL FRGQKIVQIL LLVCAIVSVP
     WMLLPKPLIL RKRYKRLENS QPFVSREFRH SDHEMNGNSN TGHSSESEEE AAESKVKSSS
     SIEKEEFDFG EIFVHQMIHT IEFVLGAVSN TASYLRLWAL SLAHSELSEV FLEKVLYGAM
     ALNNSFAVFL GFLVWFGLTI GVLCLMESLS AFLHALRLHW VEFQNKFYNL QGDGRKFVPF
     SFKSIK
//
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