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Database: UniProt
Entry: M2XWT5_GALSU
LinkDB: M2XWT5_GALSU
Original site: M2XWT5_GALSU 
ID   M2XWT5_GALSU            Unreviewed;       582 AA.
AC   M2XWT5;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 50.
DE   SubName: Full=Aspartyl protease {ECO:0000313|EMBL:EME27874.1};
GN   ORFNames=Gasu_45390 {ECO:0000313|EMBL:EME27874.1};
OS   Galdieria sulphuraria (Red alga).
OC   Eukaryota; Rhodophyta; Bangiophyceae; Galdieriales; Galdieriaceae;
OC   Galdieria.
OX   NCBI_TaxID=130081 {ECO:0000313|EMBL:EME27874.1, ECO:0000313|Proteomes:UP000030680};
RN   [1] {ECO:0000313|Proteomes:UP000030680}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=074W {ECO:0000313|Proteomes:UP000030680};
RX   PubMed=23471408; DOI=10.1126/science.1231707;
RA   Schonknecht G., Chen W.H., Ternes C.M., Barbier G.G., Shrestha R.P.,
RA   Stanke M., Brautigam A., Baker B.J., Banfield J.F., Garavito R.M., Carr K.,
RA   Wilkerson C., Rensing S.A., Gagneul D., Dickenson N.E., Oesterhelt C.,
RA   Lercher M.J., Weber A.P.;
RT   "Gene transfer from bacteria and archaea facilitated evolution of an
RT   extremophilic eukaryote.";
RL   Science 339:1207-1210(2013).
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR   EMBL; KB454526; EME27874.1; -; Genomic_DNA.
DR   RefSeq; XP_005704394.1; XM_005704337.1.
DR   AlphaFoldDB; M2XWT5; -.
DR   EnsemblPlants; EME27874; EME27874; Gasu_45390.
DR   GeneID; 17086752; -.
DR   Gramene; EME27874; EME27874; Gasu_45390.
DR   KEGG; gsl:Gasu_45390; -.
DR   eggNOG; KOG1339; Eukaryota.
DR   OMA; GASHAYG; -.
DR   OrthoDB; 3528209at2759; -.
DR   Proteomes; UP000030680; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd05471; pepsin_like; 1.
DR   CDD; cd12087; TM_EGFR-like; 1.
DR   Gene3D; 2.40.70.10; Acid Proteases; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR034164; Pepsin-like_dom.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR47966:SF51; NAPSIN-A; 1.
DR   Pfam; PF00026; Asp; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 1.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW   Hydrolase {ECO:0000256|RuleBase:RU000454};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Protease {ECO:0000256|RuleBase:RU000454, ECO:0000313|EMBL:EME27874.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030680};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        528..552
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          171..495
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   ACT_SITE        187
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   ACT_SITE        383
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
SQ   SEQUENCE   582 AA;  63532 MW;  B23C2799A93950D9 CRC64;
     MKTLSRKKVE QNESMSWVSL ATHMLRLLPG IFLFLVLCCP SGGQTSRTNN CYNTLRQRTL
     IQMGNELFLE PRQNVVRKQM DNDEILVIPL AYRVPLGRQD ILRNIFTSES RKRHLLGNNR
     ENLFRQLEQR VIQKNNDWED SPRFQTEESG IGVKRYFEQV VLGNVVNMAE YYVSLQVNGE
     SFYVQLDTGS SNLLISTTNC SHCQANKKLQ LNGLTSVSCS SSDCCQQSSS CCSKQDPSLC
     GVLVEYGSGF ASGALVKGTV TISNISVYTT FGGILNSSSD FEPTSVSGIL GMASSQLACN
     PTCVTPLFDA IVQQKSIANV FSVLLNPDNG VLVLGGVDGN FSNGSISYTD MPSSDPGYYE
     VTVSSVSVDG DDVYQTSFTA VVDTGTTLVY LPETCYNDLV KYFQSHYNNS FWDSLGALLG
     SLSSSYISSL PNVDIQLSGS VKVSIPPDSY LVSVGDGNYM FGIQSSGGSS SILGDVLLQN
     YYTVFDRVNS RIGFGPAVDV KSVNLSNVPG VGNISIPSPS TSPTLPTYGI VLIVVAGVLG
     AILLSMAVFL LVRRRRKSII PRTNVWSSQP YGVYGDSYYY YR
//
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