ID M2Y2G0_GALSU Unreviewed; 1350 AA.
AC M2Y2G0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=DNA mismatch repair protein MutS {ECO:0000313|EMBL:EME29999.1};
GN ORFNames=Gasu_25880 {ECO:0000313|EMBL:EME29999.1};
OS Galdieria sulphuraria (Red alga).
OC Eukaryota; Rhodophyta; Bangiophyceae; Galdieriales; Galdieriaceae;
OC Galdieria.
OX NCBI_TaxID=130081 {ECO:0000313|EMBL:EME29999.1, ECO:0000313|Proteomes:UP000030680};
RN [1] {ECO:0000313|Proteomes:UP000030680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=074W {ECO:0000313|Proteomes:UP000030680};
RX PubMed=23471408; DOI=10.1126/science.1231707;
RA Schonknecht G., Chen W.H., Ternes C.M., Barbier G.G., Shrestha R.P.,
RA Stanke M., Brautigam A., Baker B.J., Banfield J.F., Garavito R.M., Carr K.,
RA Wilkerson C., Rensing S.A., Gagneul D., Dickenson N.E., Oesterhelt C.,
RA Lercher M.J., Weber A.P.;
RT "Gene transfer from bacteria and archaea facilitated evolution of an
RT extremophilic eukaryote.";
RL Science 339:1207-1210(2013).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
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DR EMBL; KB454503; EME29999.1; -; Genomic_DNA.
DR RefSeq; XP_005706519.1; XM_005706462.1.
DR STRING; 130081.M2Y2G0; -.
DR EnsemblPlants; EME29999; EME29999; Gasu_25880.
DR GeneID; 17088760; -.
DR Gramene; EME29999; EME29999; Gasu_25880.
DR KEGG; gsl:Gasu_25880; -.
DR eggNOG; KOG1270; Eukaryota.
DR OrthoDB; 476at2759; -.
DR Proteomes; UP000030680; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756};
KW Reference proteome {ECO:0000313|Proteomes:UP000030680}.
FT DOMAIN 728..744
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT COILED 456..483
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1350 AA; 154455 MW; 518639F949AB3C2F CRC64;
MKRNSTVDLL NLLSNCYRFL EDARTASQLL GIALARAHGY KTKGQELPMA GVPFWAFDSY
LQRLVKAGIR VAIADQVFDG KDKSSRKVTG RAISRLVTPG TLTEEDLLQP SENNFLACVI
FETGTLSNWI GLCWLDISTG NFQCALETSH SIQEAIHSIS PSEILVLENH YEILQRTLPN
IDNRCTVSPI SFRNTYLENH SDWKQVVFSM EETLSSFQDK KKKLLSSLDI SSISELEKEA
CGLLLLYVER TLAGELPFLS SICKSPVSTF MRMDMATRKV LEISRRMNSS DDSQRGSLLA
AIRKTQTTPG ARLLAMRVNA PLTCKKSIEE RLDAVELLCR HPHLLERLRK VLKNCPEFER
PLQRLFMKRG SPRDLLDLGV TFQQVSDIKK LLDEIELPDY LQYLLRKFQN HEKLKLLLDS
CISENAPKSF SSHSATWKRT QLFGEGYIVT GYHSELDSLR GRKDELLRSL KELEIEYQKW
TSTDSLKINF NSNLGFVVEC TNTIDWNLFD EKIFHRLPPS QRTGINAYRF RTDKVNEIQN
KLNMITDQIQ ELEDSIFDKV TEQVTQHAHD IREMLGALAE LDVSCALAAL ALERNFCRPL
FVEPENANIF HVKDGRHATL EHRQLDRRTD ETFSMIPNDC FLDKHNGLLW IITGPNMAGK
STFLRQNALI AILAQIGSFV PASNVKMSIV DRIFCRVGAS DDIYGGQSTF MLEMNETANI
LKHATKNSLV IMDEVGRGTS MLEGLAIAQS IVEYLHDHIG CRTLFATHLH ELASLREKLT
SVACYYSEAF LLKETESLCF TYKVLKGSMQ CSYASKVAEL ADMPTPVVRR TNELLKGWKT
NALSEQHMDL FRMWIEKLKN IDLDALSPRE ATNLLMQWKG QLQQCEEEDG KFAFGGWDPL
KPPPTSFFGS HKTNCSIQRK YCCNNQKDSK VRFIVCCCDT EENANQQITE KVSNLYNHFP
YPPEPVRDLE PLGYNWRWHY PTAFAFCSGR MPTAPNIRIL DAGCGTGCST EYLVHLNQGA
EVIGIDISEK ALAVAAERLS KSLPHSKNRY RFIQKSLFDL DDSMGTFDLI NCVGVIHHTA
DPVMALKKLA LRLKPNGILH LFVYGKHGRW EISLMQQAIR LLLGQGNENW KEGVLIGRKL
FSVLPEGNRI RKREEERWSR DNQQDATFAD MYVHPQEVDF TIDSLFQLID SVNLQFLGFT
NPEIFDIWRL VGKQEELLVS KISCLSERER YKLVDLLDPD NMTHFEMFLA RKSFTKCNWT
QRLLGTAKIQ ISSCLQGWPS QHLLDKDYRP ITLTMSEYHF MQTAWKWYQE NGHRPTVNDV
LEHIYLQQED ILSLVDRVLI LLEPQDDNIS
//
