ID M2ZCC1_9NOCA Unreviewed; 318 AA.
AC M2ZCC1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=Fatty acid desaturase type 2 {ECO:0000313|EMBL:EME64962.1};
GN ORFNames=G352_12032 {ECO:0000313|EMBL:EME64962.1};
OS Rhodococcus ruber BKS 20-38.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Rhodococcus.
OX NCBI_TaxID=1278076 {ECO:0000313|EMBL:EME64962.1, ECO:0000313|Proteomes:UP000011731};
RN [1] {ECO:0000313|EMBL:EME64962.1, ECO:0000313|Proteomes:UP000011731}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BKS 20-38 {ECO:0000313|EMBL:EME64962.1,
RC ECO:0000313|Proteomes:UP000011731};
RX PubMed=23558535;
RA Bala M., Kumar S., Raghava G.P., Mayilraj S.;
RT "Draft Genome Sequence of Rhodococcus ruber Strain BKS 20-38.";
RL Genome Announc. 1:E0013913-E0013913(2013).
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Evidence={ECO:0000256|PIRSR:PIRSR000346-1};
CC Note=Binds 2 iron ions per subunit. {ECO:0000256|PIRSR:PIRSR000346-1};
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- SIMILARITY: Belongs to the fatty acid desaturase type 2 family.
CC {ECO:0000256|ARBA:ARBA00008749}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EME64962.1}.
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DR EMBL; AOEX01000035; EME64962.1; -; Genomic_DNA.
DR RefSeq; WP_003936501.1; NZ_AOEX01000035.1.
DR AlphaFoldDB; M2ZCC1; -.
DR PATRIC; fig|1278076.4.peg.2500; -.
DR Proteomes; UP000011731; Unassembled WGS sequence.
DR GO; GO:0045300; F:acyl-[acyl-carrier-protein] desaturase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd01050; Acyl_ACP_Desat; 1.
DR Gene3D; 1.10.620.20; Ribonucleotide Reductase, subunit A; 1.
DR InterPro; IPR005067; Fatty_acid_desaturase-2.
DR InterPro; IPR009078; Ferritin-like_SF.
DR InterPro; IPR012348; RNR-like.
DR PANTHER; PTHR31155; ACYL- ACYL-CARRIER-PROTEIN DESATURASE-RELATED; 1.
DR PANTHER; PTHR31155:SF9; STEAROYL-[ACYL-CARRIER-PROTEIN] 9-DESATURASE 7, CHLOROPLASTIC; 1.
DR Pfam; PF03405; FA_desaturase_2; 1.
DR PIRSF; PIRSF000346; Dlt9_acylACP_des; 1.
DR SUPFAM; SSF47240; Ferritin-like; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Iron {ECO:0000256|PIRSR:PIRSR000346-1};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000346-1}.
FT COILED 279..306
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 76
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR000346-1"
FT BINDING 107
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR000346-1"
FT BINDING 107
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR000346-1"
FT BINDING 110
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR000346-1"
FT BINDING 160
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR000346-1"
FT BINDING 190
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR000346-1"
FT BINDING 190
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR000346-1"
FT BINDING 193
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR000346-1"
SQ SEQUENCE 318 AA; 36375 MW; EAD85EFFEFBF4854 CRC64;
MTRVLTQLEL LRELEPVAEA NVNRHLSMAK DWHPHDYVPW DEGRNFAAMG GVDWEPEQSK
LDEVAKAAMI TNLLTEDNLP SYHREIAESF SRDGAWGTWV GRWTAEENRH GIVMRDYLVV
TRGVDPVALE NARMEHMTNG FASPNEVGML HSVSYVTFQE LATRVSHRNT GRACHDSIAD
KMLQRIAADE NLHMIFYRNI CEAALDVAPD QTLAAITDVL KNFQMPGAGM PNFRRNGVLM
AKHGIYDLRQ HLDEVVMPVL RKWRIFERED FGTEGARILD ELGTFLEELE KQAVKFEEMR
DRSLARDAAR RERTEAAS
//
