ID M3B3S9_STRMB Unreviewed; 2120 AA.
AC M3B3S9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:EMF00638.1};
GN ORFNames=H340_10255 {ECO:0000313|EMBL:EMF00638.1};
OS Streptomyces mobaraensis NBRC 13819 = DSM 40847.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1223523 {ECO:0000313|EMBL:EMF00638.1, ECO:0000313|Proteomes:UP000011740};
RN [1] {ECO:0000313|EMBL:EMF00638.1, ECO:0000313|Proteomes:UP000011740}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40847 {ECO:0000313|EMBL:EMF00638.1,
RC ECO:0000313|Proteomes:UP000011740};
RX PubMed=23558536;
RA Yang H., He T., Wu W., Zhu W., Lu B., Sun W.;
RT "Whole-Genome Shotgun Assembly and Analysis of the Genome of Streptomyces
RT mobaraensis DSM 40847, a Strain for Industrial Production of Microbial
RT Transglutaminase.";
RL Genome Announc. 1:E0014313-E0014313(2013).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMF00638.1}.
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DR EMBL; AORZ01000023; EMF00638.1; -; Genomic_DNA.
DR STRING; 1223523.H340_10255; -.
DR PATRIC; fig|1223523.3.peg.2099; -.
DR eggNOG; COG1020; Bacteria.
DR Proteomes; UP000011740; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 2.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 958..1032
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2023..2098
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2101..2120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2120 AA; 227607 MW; FFF78E7FC2DEEDD7 CRC64;
MLTRGRDGGR RAFTQSAVVV DRSLDAARLR AALATVVAAH EPLRTTFTGL AGRTAPVQVV
HDPDEQPLSV VDLPPSCADG SGPELDELRL RERAALDPRG GPVFRAALAR AGEDRAVLVL
TAHALVADRL SLRLLAGQIL AAYSGETVSP DGPPPLQYAD FAAWHHDLLT AEDAAPDRAH
WAAHTATAGT GPLPGVVRPG AAPGPWRARE WELPAELVAG IDGVAGKLST DPATVLHAAF
RIAVWRLAGE RNLPVALTRD GRSHPELRTA IGAFERELPL VHEIRHETAF AEYARALDAL
VAEGEELLDH CDPELLGSLD GTAEGPCFTF THHQADTPVR RAGITFTTVH QDSGTPIPVR
LTARRDGARL HMELGYDEGR IDETFPENAA ACLTRILEGV VSAPEGPVGD IRMLSDETAR
LLREAGLGPR VELPGKAVHE LFAEQAARTP GAVAVSAGED ALTYAELDER SNRLAHHLTG
LGVTPGRHVV VSVGRSAELL VGLLGVLKAG GAFVPVDVGF PRKRLEFVLR ETAAPVLLCT
ADVRDRVGTR TLDDAGVTPV ALDADRRRIA AHPAGPTGIA TTPDAPAYVV YTSGTTGKPN
GVRVPHRGLT NYLTWCTGAY GLDGGTGTLV HTSISFDLTL TTLFGPLLAG GQVVMLSETA
GVTGLIAALR SRRDLTLVKL TPTHLDVVNQ LLTPDELRGA VRTLVVGGEA VRAESLEPFR
ASGTRVVNEY GPSETVVGSV AHVVDAATPR TGPVPIGRPI ANTTVHLLDQ RRRPVPDGVV
GELWIGGAGV ADGYLGRPEL TGERFLPSDY PPDGGRVYRT GDLARRRADG TLEYLGRTDA
QVKIRGVRVE PAETEAVLAS HPGVGQAVVV ARLDEDPGRS SPLAGELTLT GYVVPARGAQ
APPHEELIAY CRERLPEHFV PAVLVTLDAL PVTGHGKIDR GALPKPHARA RDGAAYVAPR
TATEEILAAT VAKVLGVERV GIDDNYFVLG GDSIRSVMVA SRAQARGVEV TVADLHRHPT
VRACAAHLDA REDLPRTPVT EPFALISAED RALVPDDVED AFPLNLLQEG MIFHRDFAAK
SAVYHAIASV RLRAPFDLAV LRMVVRQLVE RHPMLRTSFD MSRFSRPLQL VHREFADPLH
YEDLRGRSAE EQDARVEEWI EREKERGFEL HEFPLIRFMA QRLEDEVFQF TYGFHHEIVD
GWSEALMITE LFSHYFSVIY DEPIAIKPPT AGMRDAVALE LEALADRRNY EFWDSYLADA
TLMRLPRPGT GPRADKGDRD ITRIAVPVPT ELSDGLKRVA AAHAVPLKTV LLAAHMVVMS
LYGGHEDTLT YTVTNGRPET ADGSTAIGLF VNSLALRVRM TGGTWADLIT ATLESERASM
PYRRLPMAEL KRHQGNEPLA ETLFFFTNYH VFHVLDRWID RGVGHVANEL YGESTFPFCG
IFRLNRETGE LEVRIEYDSL QFSDALMESV RDSYARVLAA LVADPDGRYD RHEFRSDRDR
AALAVLTRGP EAPAADRCLH DLVADRAADR PDAPAVQLDT DVLSYGELDR RANRLAHHLR
SLGIGPESVV GVLAECSLAQ IIGLLAVLKA GAAYVPLDPA QPDERLAAVI AGSGAAAVLH
RPGLEGRLPA GVRALPTDAA DGSTATHDPG PTATPRNAAY VMYTSGSTGE PKGIVVEHRN
VVASLAARGA HYAAGPGRFL LLSSFAFDSS VAGIFWTLTQ GGTLVLPGEG QQLDPAALVE
TIARQRPTHT LAIPSLLAPV LDQAAPGDLA SLRTVIAAGE SCPAELAAAC RDLLPGSTFH
NEYGPTETTV WSTVWSQENE HDGPHLPIGR PVAGTWVHPR DHRGRTVPLG VAGELSIGGA
GVARGYLGRP RDTAAAFRPD PEATAPGGRA YATGDLGRYL PDGNLEFLGR ADHQVKIRGF
RVELGEIEAV LDTHPELQRT IVMARGDHPG DQVLVAYVLP APGRRPEPAD IQGYVRDRLP
RYMVPTAVIV LDAVPLTAAG KVDRASLPAP SHAQLTRDQE YVEPGTDTER ALAAIWADVL
KLDRIGAGDR FFDVGGESLR AMQATAAANK MFRTRVSVRR LFEAPSLREF AHEIDKARLA
GGGTGLTGPA AAPATGGAAE
//
