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Database: UniProt
Entry: M3B6Y8_STRMB
LinkDB: M3B6Y8_STRMB
Original site: M3B6Y8_STRMB 
ID   M3B6Y8_STRMB            Unreviewed;       592 AA.
AC   M3B6Y8;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   05-JUL-2017, entry version 32.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:EMF01773.1};
GN   ORFNames=H340_04173 {ECO:0000313|EMBL:EMF01773.1};
OS   Streptomyces mobaraensis NBRC 13819 = DSM 40847.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1223523 {ECO:0000313|EMBL:EMF01773.1, ECO:0000313|Proteomes:UP000011740};
RN   [1] {ECO:0000313|EMBL:EMF01773.1, ECO:0000313|Proteomes:UP000011740}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40847 {ECO:0000313|EMBL:EMF01773.1,
RC   ECO:0000313|Proteomes:UP000011740};
RX   PubMed=23558536;
RA   Yang H., He T., Wu W., Zhu W., Lu B., Sun W.;
RT   "Whole-Genome Shotgun Assembly and Analysis of the Genome of
RT   Streptomyces mobaraensis DSM 40847, a Strain for Industrial Production
RT   of Microbial Transglutaminase.";
RL   Genome Announc. 1:E0014313-E0014313(2013).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EMF01773.1}.
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DR   EMBL; AORZ01000007; EMF01773.1; -; Genomic_DNA.
DR   EnsemblBacteria; EMF01773; EMF01773; H340_04173.
DR   PATRIC; fig|1223523.3.peg.848; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000011740; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011740};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011740}.
FT   DOMAIN      285    413       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      499    568       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     293    300       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   592 AA;  64924 MW;  89EF405B1FD7394D CRC64;
     MLEQLLGEGR VESKDEHWIK RCQPLALVAD TALLAVPNEF AKGVLEGRLA PVVSDALSRE
     CGRPIRIAIT VDNSVGEPAA PQPPAHEDRS HNGQGRDTYE GYDGRPGYEG RDGYGRGAGD
     DLPTVRPAYP DYQQSRAEPG SWPRHTGPAG AGPGSRAPDR GDYGWQQPRL GFAENDRDPY
     ASPQHTPSGY EQPRDPGGYR PPGGERSYEQ QRELPDAHGR GAGQGDRPVP GGSGAPGAGK
     SSGSGPGEPT ARLNPKYLFD TFVIGASNRF AHAAAVAVAE APAKAYNPLF IYGESGLGKT
     HLLHAIGHYA RSLYPGTRVR YVSSEEFTNE FINSIRDGKA DAFRKRYRDM DILLVDDIQF
     LASKESTQEE FFHTFNTLHN ANKQIVLSSD RPPKQLVTLE DRLRNRFEWG LITDVQPPEL
     ETRIAILRKK AVQEQLNAPP EVLEFIASRI SRNIRELEGA LIRVTAFASL NRQPVDLGLT
     EIVLKDLIPG GEDASPEITA PAIMAATADY FGHTVEDLCG ASRSRVLVTA RQIAMYLCRE
     LTDLSLPKIG AQFGGRDHTT VMHADRKIRA LMAERRSIYN QVTELTNRIK NG
//
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