ID   M3BS87_STRMB            Unreviewed;      1205 AA.
AC   M3BS87;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=H340_00155 {ECO:0000313|EMBL:EMF02560.1};
OS   Streptomyces mobaraensis NBRC 13819 = DSM 40847.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1223523 {ECO:0000313|EMBL:EMF02560.1, ECO:0000313|Proteomes:UP000011740};
RN   [1] {ECO:0000313|EMBL:EMF02560.1, ECO:0000313|Proteomes:UP000011740}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40847 {ECO:0000313|EMBL:EMF02560.1,
RC   ECO:0000313|Proteomes:UP000011740};
RX   PubMed=23558536;
RA   Yang H., He T., Wu W., Zhu W., Lu B., Sun W.;
RT   "Whole-Genome Shotgun Assembly and Analysis of the Genome of Streptomyces
RT   mobaraensis DSM 40847, a Strain for Industrial Production of Microbial
RT   Transglutaminase.";
RL   Genome Announc. 1:E0014313-E0014313(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|ARBA:ARBA00009922}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EMF02560.1}.
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DR   EMBL; AORZ01000001; EMF02560.1; -; Genomic_DNA.
DR   RefSeq; WP_004937434.1; NZ_CP072827.1.
DR   AlphaFoldDB; M3BS87; -.
DR   STRING; 1223523.H340_00155; -.
DR   PATRIC; fig|1223523.3.peg.35; -.
DR   eggNOG; COG0210; Bacteria.
DR   eggNOG; COG2887; Bacteria.
DR   Proteomes; UP000011740; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   CDD; cd17932; DEXQc_UvrD; 1.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}.
FT   BINDING         38..45
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   1205 AA;  129510 MW;  F050818BD496AED2 CRC64;
     MTPRLTDPEQ LKELLGIPFT PEQTACITAP PAPQVIVAGA GSGKTTVMAA RVVWLVGTGQ
     VAPERVLGLT FTNKAAGELA ERVRKALAAA GVTAGEATEE EGPGEPRIST YHAFAGRLLK
     EHGLRIGLEP TARLLADATR YQLAARVLRT SPGPHPALTR PFGDLVADLL ALDAELAEHL
     VEPEELLAHD EALLKDLDGA RLTNADLRKV PETARARREL TGLVAAYRAE KRRRDLLDFG
     DQIALSAELA RTRPEVGRIL RDEFSVVLLD EYQDTSVAQR LLLAGLFGGG TGHAVTAVGD
     PCQAIYGWRG ASVANLDEFP RHFPHADGRP AARHSLSENR RSGGRLLRLA NGLAAPLRAL
     HEGVEALRPA PGAERDGYVR CALLPTQAEE LAWLADSIAH HVRTGTRPGD VAVLCRTAAD
     FARIQAALVE RDVPVEVVGL SGLLHLPEIA DLVAVCEVLQ DPTANASLVR LLTGPRWRIG
     PRDLALLGRR ARTLVPYGSA GTDPERRLAE AVEGRDPAEV ISLADALDTF LTGDAPDDGL
     PFSAEARIRF ARLATELRDL RRGLADPLMD VLHRVLATTG LEVELSASPH ALAARRRETL
     NRFLDIAAGF AGLDGDAGLL AFLGFLRTAV QYEKGLDSSL PGSEDTVKVL TAHKSKGLEW
     DVVAVPGLVA KTFPSEQARD AWTSQARVLP HTLRGDADTL PEVPAWDGKG IAAFKAAMRD
     HQATEELRLG YVTFTRPRSL LLASGHWWGP EQKRPRGPSA FLHALREHCE AGHGEIEAWA
     DPPEEGATNP ALDAAETDRA WPLPLDPGSL ALRREAADAV RARLGRLPGL TPAPMAAHDP
     EWPPPPEEDG EAYPYADSAY EEEYGDAAAH GEEPERDAAA YEDLAHEDDA ALADWDALPT
     TRPTATAPDG TRAAEQTGSP APVAPQPQAL TVVPPPRHER TPAAPREPSA PSAAPRVGLT
     PEESRLVASW DRDLDALAGE LRRARASVHE VPLPASLTAS QLVRLAADPD AFAAELARPM
     PRPPRPAARR GTRFHAWVES RFEALTLPFT VPDGLPGGVD DDERDETDDS GIADERDLAE
     LKAAFERTPY AHRTPYRVEA PFRITLAGRV IRGRIDAVYR TGEEVDGTGA AYEIVDWKTG
     RDGTADPLQL AVYRLAWAER HGLPPSAVSA AFVHVRDGRV VRPTALPDRA GLERILLGGG
     AGEGE
//