ID   M3CNP1_LEPIR            Unreviewed;       749 AA.
AC   M3CNP1;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Adenylate/guanylate cyclase catalytic domain protein {ECO:0000313|EMBL:EMF43124.1};
GN   ORFNames=LEP1GSC067_4074 {ECO:0000313|EMBL:EMF43124.1};
OS   Leptospira interrogans serovar Lora str. TE 1992.
OC   Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC   Leptospira.
OX   NCBI_TaxID=1193028 {ECO:0000313|EMBL:EMF43124.1, ECO:0000313|Proteomes:UP000011754};
RN   [1] {ECO:0000313|EMBL:EMF43124.1, ECO:0000313|Proteomes:UP000011754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TE 1992 {ECO:0000313|EMBL:EMF43124.1,
RC   ECO:0000313|Proteomes:UP000011754};
RA   Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA   Sanka R., DePew J., Purushe J., Hartskeerl R.A., Ahmed A.,
RA   van der Linden H., Goris M.G.A., Vinetz J.M., Sutton G.G., Nierman W.C.,
RA   Fouts D.E.;
RL   Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC       {ECO:0000256|ARBA:ARBA00005381}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EMF43124.1}.
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DR   EMBL; AKWW02000030; EMF43124.1; -; Genomic_DNA.
DR   AlphaFoldDB; M3CNP1; -.
DR   Proteomes; UP000011754; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   CDD; cd06225; HAMP; 1.
DR   Gene3D; 1.10.8.500; HAMP domain in histidine kinase; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SUPFAM; SSF158472; HAMP domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        170..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        435..453
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          454..506
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          538..670
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   749 AA;  85011 MW;  5DE920EA2B3BE347 CRC64;
     MTEDKTFLFC SRLKEGGMLD RWKDKNDKSV RWEELPNLHS DLQDLDLIIR SLISEKLSLG
     IREIIFCLSA EQALSLKKSR DFLKLIKDLK RAGFTISSAD KDKILSTNVE SSSKFFRYLE
     NRSRNVNCLV WTEDLALSQI ESKYYDFLNH FHGYKFESFR PSRFTIRVKL LSIVSAIITL
     SMGLMITMAT YFFRKYSEIL IQEYNLSLAR MTGIQLSGQL KETTRKIQDF RSEDSEKFFR
     TNSNAVAYVR FKNKTVNSAL EIDSLFWNSK FLKSNSVVPD PTNLKNALEK SFSRLSGTLE
     VLNVSNEFGF PAVAVLLPVG VEISGLVFSA SEFLGSFLSV RQTDFFQMIV VDSSGNLIAH
     SNDKEAVSGK DYKKHPLVEN MLRSPSDNGS QRFDFEGREV LGSYQQLEVG GLGIISTLDA
     DIAFEAVYKI RRQNFWIMIS VLSVAFFVVF VFSRTLTIPI IQLLSATKKV EQGNYAVDIR
     ATTHDEVGVL TNSFLRMARG LEEREKIKNT FGKFVNKEIA ERALSSDLKL GGENREVTVF
     FSDLRNFTGM SEKMKPEEVV EFLNQYFTEM VECIYLTQGI VDKFIGDAVM AHWGALVYDG
     NEAKNSINAA LLMRRALIEF NLKGKEIGRP FTRFGCGINS GPVIVGQIGS EKKLEFTVIG
     DTVNLASRIE YLNKEFGTDI LISESTYQQA KDHFNFVELP PVWIRGKEKP QVVYAVLGWK
     DDQDCPKSLE ELRTLCGIPD PENPSRSLA
//