ID M3ES87_LEPIR Unreviewed; 705 AA.
AC M3ES87;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Flagellar biosynthesis protein FlhA {ECO:0000256|RuleBase:RU364093};
GN Name=flhA {ECO:0000256|RuleBase:RU364093,
GN ECO:0000313|EMBL:EMF41217.1};
GN ORFNames=LEP1GSC067_0862 {ECO:0000313|EMBL:EMF41217.1};
OS Leptospira interrogans serovar Lora str. TE 1992.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1193028 {ECO:0000313|EMBL:EMF41217.1, ECO:0000313|Proteomes:UP000011754};
RN [1] {ECO:0000313|EMBL:EMF41217.1, ECO:0000313|Proteomes:UP000011754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TE 1992 {ECO:0000313|EMBL:EMF41217.1,
RC ECO:0000313|Proteomes:UP000011754};
RA Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA Sanka R., DePew J., Purushe J., Hartskeerl R.A., Ahmed A.,
RA van der Linden H., Goris M.G.A., Vinetz J.M., Sutton G.G., Nierman W.C.,
RA Fouts D.E.;
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for formation of the rod structure of the flagellar
CC apparatus. Together with FliI and FliH, may constitute the export
CC apparatus of flagellin. {ECO:0000256|RuleBase:RU364093}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU364093};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU364093}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC pore) family. {ECO:0000256|ARBA:ARBA00008835,
CC ECO:0000256|RuleBase:RU364093}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMF41217.1}.
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DR EMBL; AKWW02000062; EMF41217.1; -; Genomic_DNA.
DR AlphaFoldDB; M3ES87; -.
DR Proteomes; UP000011754; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 3.40.30.60; FHIPEP family, domain 1; 1.
DR Gene3D; 1.10.8.540; FHIPEP family, domain 3; 1.
DR Gene3D; 3.40.50.12790; FHIPEP family, domain 4; 1.
DR InterPro; IPR042194; FHIPEP_1.
DR InterPro; IPR042193; FHIPEP_3.
DR InterPro; IPR042196; FHIPEP_4.
DR InterPro; IPR006301; FlhA.
DR InterPro; IPR001712; T3SS_FHIPEP.
DR NCBIfam; TIGR01398; FlhA; 1.
DR PANTHER; PTHR30161:SF1; FLAGELLAR BIOSYNTHESIS PROTEIN FLHA-RELATED; 1.
DR PANTHER; PTHR30161; FLAGELLAR EXPORT PROTEIN, MEMBRANE FLHA SUBUNIT-RELATED; 1.
DR Pfam; PF00771; FHIPEP; 1.
DR PIRSF; PIRSF005419; FlhA; 1.
DR PRINTS; PR00949; TYPE3IMAPROT.
PE 3: Inferred from homology;
KW Bacterial flagellum biogenesis {ECO:0000256|RuleBase:RU364093};
KW Bacterial flagellum protein export {ECO:0000256|RuleBase:RU364093};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU364093};
KW Cell projection {ECO:0000313|EMBL:EMF41217.1};
KW Cilium {ECO:0000313|EMBL:EMF41217.1};
KW Flagellum {ECO:0000313|EMBL:EMF41217.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364093};
KW Protein transport {ECO:0000256|RuleBase:RU364093};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364093};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364093}; Transport {ECO:0000256|RuleBase:RU364093}.
FT TRANSMEM 12..28
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 35..54
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 60..77
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 111..132
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 202..221
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 282..315
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
SQ SEQUENCE 705 AA; 77297 MW; 9B62858C21274489 CRC64;
MEKKWWNQSD VILGIGAVAV VAMLVIPLPG FILDILIIVS LAIGLLVLLT SLSVNEPADF
SIFPSLLLIT TLYRLALNVS TTRQILSKGP AMNSHVIDAF GSFIIGSESG LSKYVVGFII
FIILVLVQIL VITKGATRIS EVAARFTLDA LPGKQMAIDM ELSSGNINEE EAKKRRKRIE
AEVDFYGSMD GASKFVQGDV RAGLIITAIN LLGGVIIGSS IRGESFTQAI ETYGKFTIGD
GLVSQIPALL TTVATGIIVT RSGSESDLAT QFKSQLFSNS KVLYVVAGSL GFAAFIPGLP
FIPLVLLSAG IAYLGYSLEQ TVKEQLESIE KKEKESGQDR KPKDFYEELR TDPIEIEVGY
HLIPLVDVSQ GGALLDQISN LRKKFAQDNG VVIPPVRILD NLDLNPDTYS IKINGTEVGA
STVKPDKLMA LNTSPGSAES IAGEDFLEPS FGQRAKWISA EDKSDAEAKG YTVVDASTVV
VTHLKELLAT HASTLLGREE VKKLLDHYKT SYPTLIGELD ADKPGNLGII QQVLQNLLRE
GLGIRNLVPI LESIANNLSK YQNPYILTEL VRQSISRTVV RDYLSMDGKL RVITLESRIL
DRLNKSITQD RIENRDVLSL APDFYRRLID SVAELYRNFR TEGKFPIFVV NREVRLPFSY
MLAKEFPPRN FGVLAYEEIH SSVDSVIEAE LKLPQAQTAG ISEET
//
