ID M3FR70_9LEPT Unreviewed; 721 AA.
AC M3FR70;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=7TM diverse intracellular signaling {ECO:0000313|EMBL:EMF82827.1};
GN ORFNames=LEP1GSC188_2922 {ECO:0000313|EMBL:EMF82827.1};
OS Leptospira weilii serovar Topaz str. LT2116.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1088540 {ECO:0000313|EMBL:EMF82827.1, ECO:0000313|Proteomes:UP000011770};
RN [1] {ECO:0000313|EMBL:EMF82827.1, ECO:0000313|Proteomes:UP000011770}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2116 {ECO:0000313|EMBL:EMF82827.1,
RC ECO:0000313|Proteomes:UP000011770};
RA Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA Sanka R., DePew J., Purushe J., Tulsiani S.M., Graham G.C., Burns M.-A.,
RA Dohnt M.F., Smythe L.D., McKay D.B., Craig S.B., Vinetz J.M., Sutton G.G.,
RA Nierman W.C., Fouts D.E.;
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMF82827.1}.
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DR EMBL; AHOR02000017; EMF82827.1; -; Genomic_DNA.
DR AlphaFoldDB; M3FR70; -.
DR Proteomes; UP000011770; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR011623; 7TMR_DISM_rcpt_extracell_dom1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR PANTHER; PTHR43081:SF16; BLL2853 PROTEIN; 1.
DR Pfam; PF07695; 7TMR-DISM_7TM; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011770};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 220..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 392..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 469..595
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 721 AA; 83038 MW; 5BF02C728330DA2B CRC64;
MEEKIKKSSM IRFSFFQRQV LLFFGLFFVL NQCALELERP QVSAVSGVID LSSWNFEKYG
PVALQGDWTF RWKEFIEDPE VNSERNRLMP VPKAWTRIKE PHGENYPGTG IATYFLKVIL
PKDLSSTNLA ILAETSETAY EVWVDKVKIG TQGIPGKTLD TSTPEWNVKI LPFQVQKKEF
QIRIPLSNFY HARGGLTARL ILGNEDQIIR LREKRMTVDV FLLGFLIAMA LYHFTLYFLR
KKDAALLYFG VLCFVFCFRE ISTEQNLIQV IFPGVSYLVH MKIVYLSFYL IPPITSAFLR
ALFPEELKKE IHYIVVFIAT IFSLIVVSQD PVLFTGTIEY YYVFTFLCFA VGFYVLALAL
VRKKTGAIAI LIGIFAVFLA YSQDIFYNKR IIPTFILAPF GLIALIFSEA YLLAKRYSLA
FNAMEDVSES LKKVNSSYRL FVPKELLRIL NKHDVLDIKL GDIAEEEMSL LYNEVRTFSD
SSEKMTRKEN FKFINSFLGK VGPVIRERDG FIDKYFGEAF LALFPPEPEK ALESAIEIQR
ILREFNRERI ANGKDPIRSG SGIHTGPILL GTIGEAERME STVISFSVNV ASKIGQLSRT
YESSLLITDS TLFRLTNSSE YFYRVVDRIQ IRDQRSVYTV LEVFNGLPEN LIDSYMNTRE
EFERGILLFR EKHFEEACVV FNRILEKNRV DQAARVYLEK SVHNCRFGVP ENWQGVTLLG
D
//