ID M3MAV5_HELPX Unreviewed; 1001 AA.
AC M3MAV5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=HMPREF1402_01284 {ECO:0000313|EMBL:EMG97537.1};
OS Helicobacter pylori GAM121Aii.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=1159030 {ECO:0000313|EMBL:EMG97537.1, ECO:0000313|Proteomes:UP000011875};
RN [1] {ECO:0000313|EMBL:EMG97537.1, ECO:0000313|Proteomes:UP000011875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GAM121Aii {ECO:0000313|EMBL:EMG97537.1,
RC ECO:0000313|Proteomes:UP000011875};
RA Weinstock G., Sodergren E., Lobos E.A., Fulton L., Fulton R., Courtney L.,
RA Fronick C., O'Laughlin M., Godfrey J., Wilson R.M., Miner T., Farmer C.,
RA Delehaunty K., Cordes M., Minx P., Tomlinson C., Chen J., Wollam A.,
RA Pepin K.H., Bhonagiri V., Zhang X., Suruliraj S., Antonio M., Secka O.,
RA Thomas J., Warren W., Mitreva M., Mardis E.R., Wilson R.K.;
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMG97537.1}.
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DR EMBL; APDG01000062; EMG97537.1; -; Genomic_DNA.
DR RefSeq; WP_001939480.1; NZ_KB636375.1.
DR AlphaFoldDB; M3MAV5; -.
DR PATRIC; fig|1159030.3.peg.1203; -.
DR HOGENOM; CLU_005122_1_2_7; -.
DR Proteomes; UP000011875; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR CDD; cd18810; SF2_C_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR30580; PRIMOSOMAL PROTEIN N; 1.
DR PANTHER; PTHR30580:SF0; PRIMOSOMAL PROTEIN N; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}.
FT DOMAIN 499..658
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 671..835
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1001 AA; 113415 MW; B6914FC7FA7F8FD0 CRC64;
MIQSSLYKAL NKGFDYQILA CKDFKESRLA KEVISYFKPN TKAVLFPEFR AKRNDDLRSF
FEEFLQLLGA LREFYQALEN KQETIIIAPI NALLHPLPKK ELLKSFKITL LEKYNLKDLK
DKLFYYGYEI LDLVEVEGEA SFRGDIVDIY IPNSKAYRLS FFDAECESIK ELDPTTQMSL
KEDLLEIEIP PTLFSLDEPS YKDLKTKVEQ SPLNSFSKDL TSFGLWFLGE KANDLLGVYQ
SIISPKALEE IQELASLNEL DDERFKFLKV LENAQGYEDL EIHAHALEGF IALHSNHKIT
LLAPNKTILD NAISALDAGN MECVIAPFVL NFKTPDRIFI SLNSFERKKK RQKSKLALNE
LNPGEWVVHD DYGVGVFSQL IQHSVLGSKR DFLEIAYLGE DKLLLPVENL HLIARYVAQS
DSVPVKDRLG KGSFLKLKAK VRTKLLEIAG KIIELAAERN LILGKKMDTH LAELEVFKSH
AGFEYTSDQE KAIAEISRDL SSHRVMDRLL SGDVGFGKTE VAMHAIFCAF LNGFQSALVV
PTTLLAHQHF ETLRARFENF GVKVARLDRY IKTSEKSKLL KAVELGLVDA LIGTHAILGA
KFKNLGLMVV DEEHKFGVKQ KEALKELSKS VHFLSMSATP IPRTLNMALS QIKGISSLKT
PPTDRKPSRT FLKEKNDELL KEIIHRELRR NGQIFYIHNH IASISKVKTK LEELIPKLKI
AILHSQINAH ESEEIMLEFA KGNYQVLLCT SIVESGIHLP NANTIIIDNA QNFGLADLHQ
LRGRVGRGKK EGFCYFLIED QKSLNEQALK RLLALEKNSY LGSGESIAYH DLEIRGGGNL
LGQDQSGHIK NIGYALYTRM LEDAIYELSG GKKRLEKSVE IQLGVSAFLN PELIASDSLR
LDLYRRLSLC EDVDEVGQIH EEIEDRFGKI DDLSAQFLQI ITLKILANQL GILKLSNFNQ
NITLTYSDEK KESLKAPSKD DNDILETLLK HLHAQISLKR R
//
