ID M3MSS8_HELPX Unreviewed; 250 AA.
AC M3MSS8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 13-SEP-2023, entry version 29.
DE RecName: Full=Beta-lactamase {ECO:0000256|ARBA:ARBA00012865, ECO:0000256|RuleBase:RU366075};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865, ECO:0000256|RuleBase:RU366075};
GN ORFNames=HMPREF1396_00948 {ECO:0000313|EMBL:EMG86781.1};
OS Helicobacter pylori GAM114Ai.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=1159024 {ECO:0000313|EMBL:EMG86781.1, ECO:0000313|Proteomes:UP000012016};
RN [1] {ECO:0000313|EMBL:EMG86781.1, ECO:0000313|Proteomes:UP000012016}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GAM114Ai {ECO:0000313|EMBL:EMG86781.1,
RC ECO:0000313|Proteomes:UP000012016};
RA Weinstock G., Sodergren E., Lobos E.A., Fulton L., Fulton R., Courtney L.,
RA Fronick C., O'Laughlin M., Godfrey J., Wilson R.M., Miner T., Farmer C.,
RA Delehaunty K., Cordes M., Minx P., Tomlinson C., Chen J., Wollam A.,
RA Pepin K.H., Bhonagiri V., Zhang X., Suruliraj S., Antonio M., Secka O.,
RA Thomas J., Warren W., Mitreva M., Mardis E.R., Wilson R.K.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Hydrolyzes 6-aminopenicillinic acid and 7-
CC aminocephalosporanic acid (ACA) derivatives.
CC {ECO:0000256|RuleBase:RU366075}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526,
CC ECO:0000256|RuleBase:RU366075};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU366075}.
CC -!- SIMILARITY: Belongs to the hcp beta-lactamase family.
CC {ECO:0000256|ARBA:ARBA00008486, ECO:0000256|RuleBase:RU366075}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMG86781.1}.
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DR EMBL; APDA01000035; EMG86781.1; -; Genomic_DNA.
DR RefSeq; WP_001930520.1; NZ_KB642386.1.
DR AlphaFoldDB; M3MSS8; -.
DR PATRIC; fig|1159024.3.peg.907; -.
DR HOGENOM; CLU_000288_36_2_7; -.
DR Proteomes; UP000012016; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008800; F:beta-lactamase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR040239; HcpB-like.
DR InterPro; IPR006597; Sel1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR13891:SF1; CYTOCHROME C OXIDASE ASSEMBLY FACTOR 7; 1.
DR PANTHER; PTHR13891; UNCHARACTERIZED; 1.
DR Pfam; PF08238; Sel1; 5.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00671; SEL1; 6.
DR SMART; SM00028; TPR; 2.
DR SUPFAM; SSF81901; HCP-like; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU366075};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU366075};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803}.
SQ SEQUENCE 250 AA; 27507 MW; 5456532308CE2608 CRC64;
MLGSVKKTLF GVLCLGALCL RWLMAEPDAK ELVNLGIESV KKQDFAQAKA YFEKACELKE
GFGCVFLGAF YEEGKGVGKD LKKAIQFYTK GCELNDGYGC RLLGNLYYNG QGVSKDAKKA
SQYYSKSCEL NHAEGCTVLG SLHHYGVGTP KDLRKALDLY EKACDLKDSP GCINAGYMYG
VAKNFKEAIV RYSKACELKD GRGCYNLGVM QYNAQGTTKD EKQAVENFKK GCKSSVKEAC
DALKELKIEL
//