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Database: UniProt
Entry: M3PWG1_HELPX
LinkDB: M3PWG1_HELPX
Original site: M3PWG1_HELPX 
ID   M3PWG1_HELPX            Unreviewed;       250 AA.
AC   M3PWG1;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   13-SEP-2023, entry version 28.
DE   RecName: Full=Beta-lactamase {ECO:0000256|ARBA:ARBA00012865, ECO:0000256|RuleBase:RU366075};
DE            EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865, ECO:0000256|RuleBase:RU366075};
GN   ORFNames=HMPREF1421_00688 {ECO:0000313|EMBL:EMH29238.1};
OS   Helicobacter pylori GAM265BSii.
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=1159049 {ECO:0000313|EMBL:EMH29238.1, ECO:0000313|Proteomes:UP000011872};
RN   [1] {ECO:0000313|EMBL:EMH29238.1, ECO:0000313|Proteomes:UP000011872}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GAM265BSii {ECO:0000313|EMBL:EMH29238.1,
RC   ECO:0000313|Proteomes:UP000011872};
RA   Weinstock G., Sodergren E., Lobos E.A., Fulton L., Fulton R., Courtney L.,
RA   Fronick C., O'Laughlin M., Godfrey J., Wilson R.M., Miner T., Farmer C.,
RA   Delehaunty K., Cordes M., Minx P., Tomlinson C., Chen J., Wollam A.,
RA   Pepin K.H., Bhonagiri V., Zhang X., Suruliraj S., Antonio M., Secka O.,
RA   Thomas J., Warren W., Mitreva M., Mardis E.R., Wilson R.K.;
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hydrolyzes 6-aminopenicillinic acid and 7-
CC       aminocephalosporanic acid (ACA) derivatives.
CC       {ECO:0000256|RuleBase:RU366075}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC         Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC         ChEBI:CHEBI:140347; EC=3.5.2.6;
CC         Evidence={ECO:0000256|ARBA:ARBA00001526,
CC         ECO:0000256|RuleBase:RU366075};
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC       ECO:0000256|RuleBase:RU366075}.
CC   -!- SIMILARITY: Belongs to the hcp beta-lactamase family.
CC       {ECO:0000256|ARBA:ARBA00008486, ECO:0000256|RuleBase:RU366075}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EMH29238.1}.
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DR   EMBL; APDY01000039; EMH29238.1; -; Genomic_DNA.
DR   RefSeq; WP_000901645.1; NZ_KB642344.1.
DR   AlphaFoldDB; M3PWG1; -.
DR   PATRIC; fig|1159049.3.peg.645; -.
DR   HOGENOM; CLU_000288_36_2_7; -.
DR   Proteomes; UP000011872; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008800; F:beta-lactamase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR040239; HcpB-like.
DR   InterPro; IPR006597; Sel1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR13891:SF1; CYTOCHROME C OXIDASE ASSEMBLY FACTOR 7; 1.
DR   PANTHER; PTHR13891; UNCHARACTERIZED; 1.
DR   Pfam; PF08238; Sel1; 5.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00671; SEL1; 5.
DR   SMART; SM00028; TPR; 2.
DR   SUPFAM; SSF81901; HCP-like; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU366075};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU366075};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803}.
SQ   SEQUENCE   250 AA;  27352 MW;  2B7702E55F452759 CRC64;
     MLGSVKKTLF GVLCLGALCL RGLMAEPDAK ELVNLGIESV KKQDFAQAKA HFEKACELKE
     GFGCVFLGAF YEEGKGVGKD LKKAIQFYTK GCELNDGYGC RLLGNLYYNG QGVSKDAKKA
     SQYYSKSCEL NHAEGCTVLG SLHHYGVGTP KDLRKALDLY EKACDLKDSP GCINAGYMYG
     VAKNFKEAIV RYSKACELKD GRGCYNLGVM QYNAQGTTKD EKQAVENFKK GCKSSVKEAC
     DALKELKIEL
//
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