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Database: UniProt
Entry: M3VC86_9ACTN
LinkDB: M3VC86_9ACTN
Original site: M3VC86_9ACTN 
ID   M3VC86_9ACTN            Unreviewed;       505 AA.
AC   M3VC86;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   05-JUL-2017, entry version 32.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:GAC81578.1};
GN   ORFNames=GM1_038_00310 {ECO:0000313|EMBL:GAC81578.1};
OS   Gordonia malaquae NBRC 108250.
OC   Bacteria; Actinobacteria; Corynebacteriales; Gordoniaceae; Gordonia.
OX   NCBI_TaxID=1223542 {ECO:0000313|EMBL:GAC81578.1, ECO:0000313|Proteomes:UP000035009};
RN   [1] {ECO:0000313|EMBL:GAC81578.1, ECO:0000313|Proteomes:UP000035009}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 108250 {ECO:0000313|EMBL:GAC81578.1,
RC   ECO:0000313|Proteomes:UP000035009};
RA   Yoshida I., Hosoyama A., Tsuchikane K., Ando Y., Baba S., Ohji S.,
RA   Hamada M., Tamura T., Yamazoe A., Yamazaki S., Fujita N.;
RT   "Whole genome shotgun sequence of Gordonia malaquae NBRC 108250.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:GAC81578.1}.
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DR   EMBL; BAOP01000038; GAC81578.1; -; Genomic_DNA.
DR   RefSeq; WP_008381451.1; NZ_BAOP01000038.1.
DR   EnsemblBacteria; GAC81578; GAC81578; GM1_038_00310.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000035009; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000035009};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035009}.
FT   DOMAIN      198    326       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      410    478       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     206    213       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   505 AA;  56718 MW;  00377967386864CD CRC64;
     MPSDRESFND VWGKVVAELT DGTGPQGAQP LSRMQKAWLS LVQPLTMTEG FALLAVPTPL
     VQEQIERDLR DLIRATLNRH LDQTVDIAVR VAEPQEVAPA PVETMGTTSP VTPVTPVTDA
     TPSGQFASLN YDDQPTQGPH PGPREWTTYF SDRDVATPAE SSTTSLHPRY TFDTFVIGAS
     NRFAHASAVA VAENPARAYN PLFIWGESGL GKTHLLHAAG HYAQRLYPGM RVKYVSTEEF
     TNDFINSLRD DRRAVFKRRY RDIDMLLIDD IQFLEGREGI QEEFFHTFNT LHNANKQIVV
     SSDRPPKQLA TLEDRLRTRF EWGLITDVQP PDLETRIAIL RKKAQMDKLA APDDVLELIA
     SKIERNIREL EGALIRVTAF ASLQNAELDR SLAEVVLKAL MPDDGSIEIS AASILAISAE
     YFDISIEDLR GPSKVRNVTQ ARQIAMYLCR ELTDLSLPKI GEAFDRDHTT VMHAVKKINK
     EMPERPKVYD HVQELTARVK QRANR
//
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