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Database: UniProt
Entry: M3VHA3_PIG
LinkDB: M3VHA3_PIG
Original site: M3VHA3_PIG 
ID   M3VHA3_PIG              Unreviewed;       643 AA.
AC   M3VHA3;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 41.
DE   SubName: Full=Alpha-L-iduronidase {ECO:0000313|EMBL:JAA74263.1, ECO:0000313|Ensembl:ENSSSCP00000034841.1};
GN   Name=IDUA {ECO:0000313|EMBL:JAA74263.1,
GN   ECO:0000313|Ensembl:ENSSSCP00000034841.1,
GN   ECO:0000313|VGNC:VGNC:89026};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|EMBL:JAA74263.1};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000034841.1, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000034841.1,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:JAA74263.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Dawson H.D., Chen C.T.;
RT   "Global Gene Expression Profiling of Alveolar Macrophages by Deep
RT   Sequencing.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:HDA71109.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=30723633; DOI=.7717/peerj.6374;
RA   Gilbert D.G.;
RT   "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL   PeerJ 7:E6374-E6374(2019).
RN   [4] {ECO:0000313|Ensembl:ENSSSCP00000034841.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 39 family.
CC       {ECO:0000256|ARBA:ARBA00008875}.
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DR   EMBL; DQIR01115633; HDA71109.1; -; Transcribed_RNA.
DR   EMBL; DQIR01206790; HDB62267.1; -; Transcribed_RNA.
DR   EMBL; DQIR01217634; HDB73111.1; -; Transcribed_RNA.
DR   EMBL; DQIR01228854; HDB84331.1; -; Transcribed_RNA.
DR   EMBL; DQIR01269854; HDC25332.1; -; Transcribed_RNA.
DR   EMBL; DQIR01277991; HDC33469.1; -; Transcribed_RNA.
DR   EMBL; GACC01000321; JAA74263.1; -; mRNA.
DR   STRING; 9823.ENSSSCP00000034841; -.
DR   Ensembl; ENSSSCT00000052188.3; ENSSSCP00000034841.1; ENSSSCG00000032262.3.
DR   VGNC; VGNC:89026; IDUA.
DR   GeneTree; ENSGT00390000015494; -.
DR   OMA; AHYTSGD; -.
DR   OrthoDB; 4589at2759; -.
DR   Reactome; R-SSC-2024096; HS-GAG degradation.
DR   Reactome; R-SSC-2024101; CS/DS degradation.
DR   Proteomes; UP000008227; Chromosome 8.
DR   Bgee; ENSSSCG00000032262; Expressed in granulosa cell and 40 other cell types or tissues.
DR   GO; GO:0003940; F:L-iduronidase activity; IBA:GO_Central.
DR   GO; GO:0030209; P:dermatan sulfate catabolic process; IEA:Ensembl.
DR   GO; GO:0030211; P:heparin catabolic process; IEA:Ensembl.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR049165; GH39_as.
DR   InterPro; IPR049167; GH39_C.
DR   InterPro; IPR049166; GH39_cat.
DR   InterPro; IPR000514; Glyco_hydro_39.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR013783; Ig-like_fold.
DR   PANTHER; PTHR12631; ALPHA-L-IDURONIDASE; 1.
DR   PANTHER; PTHR12631:SF8; ALPHA-L-IDURONIDASE; 1.
DR   Pfam; PF01229; Glyco_hydro_39; 1.
DR   Pfam; PF21200; Glyco_hydro_39_C; 1.
DR   PRINTS; PR00745; GLHYDRLASE39.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 1.
DR   SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
DR   PROSITE; PS01027; GLYCOSYL_HYDROL_F39; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..643
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014582352"
FT   DOMAIN          29..524
FT                   /note="Glycosyl hydrolases family 39 N-terminal catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01229"
FT   DOMAIN          552..639
FT                   /note="Alpha-L-iduronidase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF21200"
FT   ACT_SITE        181
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600514-1"
SQ   SEQUENCE   643 AA;  71610 MW;  7B83014CD5887DF8 CRC64;
     MRPPRPHASL LELLGVLLAA SLAAAEAPHL VRVDAARALG PLRPFWRSTG FCPPLPHSQA
     HRYDLSWDQQ LNLAYVGAVP HGGIQQVRAH WLLGLVTARR SAGQGLSYNF THLDRYLDLL
     RENQLLPGFE LMGSPSGHFT DFEDKQQVFE WRNLVSLLAR RYVGRYGLKH VSKWNFETWN
     EPDHHDFDNV SMTLQGFLNY YDACSEGLRA ASPALRLGGP GDSFHDPPRS PLCWGLLAHC
     HNGTNFFTGE VGVRLDFIAL HKKGAGSSIY ILEQEVAVMQ QIQRLFPKFT DTPIYNDEAD
     PLVGWSLPQP WRADVTYAAM VVKVIAQHQN LLVANTSSSI RYTLLSNDNA FLSYHPHPFS
     QRTLTARFQV NNTRPPHVQL LRKPVLTAMG LLALLDSEQL WAEVSQAGRV LDSNHTVGVL
     ASAHRPTGPA DAWRATVLVY ASDDTRAHAN RSVPLILSLH GVPPGPGLVF VQLYMDNSIS
     SPDGEWRRLG RPVFPSAQQL RRMRAAEDPA AVRPLPFPPS GRLTLSPELP LPSLLLVHVC
     ARPEAPPGQV SRLRALPLTR GQLLLVWSDE RVGSKCLWDY EIQFCPEGGV YTRVDRKPST
     FNLFVFSPDT AVVSGSYRVR AVDYWARPGP FSSPVRYLEV PAG
//
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