ID M3VHA3_PIG Unreviewed; 643 AA.
AC M3VHA3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Alpha-L-iduronidase {ECO:0000313|EMBL:JAA74263.1, ECO:0000313|Ensembl:ENSSSCP00000034841.1};
GN Name=IDUA {ECO:0000313|EMBL:JAA74263.1,
GN ECO:0000313|Ensembl:ENSSSCP00000034841.1,
GN ECO:0000313|VGNC:VGNC:89026};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|EMBL:JAA74263.1};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000034841.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000034841.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAA74263.1}
RP NUCLEOTIDE SEQUENCE.
RA Dawson H.D., Chen C.T.;
RT "Global Gene Expression Profiling of Alveolar Macrophages by Deep
RT Sequencing.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:HDA71109.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [4] {ECO:0000313|Ensembl:ENSSSCP00000034841.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 39 family.
CC {ECO:0000256|ARBA:ARBA00008875}.
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DR EMBL; DQIR01115633; HDA71109.1; -; Transcribed_RNA.
DR EMBL; DQIR01206790; HDB62267.1; -; Transcribed_RNA.
DR EMBL; DQIR01217634; HDB73111.1; -; Transcribed_RNA.
DR EMBL; DQIR01228854; HDB84331.1; -; Transcribed_RNA.
DR EMBL; DQIR01269854; HDC25332.1; -; Transcribed_RNA.
DR EMBL; DQIR01277991; HDC33469.1; -; Transcribed_RNA.
DR EMBL; GACC01000321; JAA74263.1; -; mRNA.
DR STRING; 9823.ENSSSCP00000034841; -.
DR Ensembl; ENSSSCT00000052188.3; ENSSSCP00000034841.1; ENSSSCG00000032262.3.
DR VGNC; VGNC:89026; IDUA.
DR GeneTree; ENSGT00390000015494; -.
DR OMA; AHYTSGD; -.
DR OrthoDB; 4589at2759; -.
DR Reactome; R-SSC-2024096; HS-GAG degradation.
DR Reactome; R-SSC-2024101; CS/DS degradation.
DR Proteomes; UP000008227; Chromosome 8.
DR Bgee; ENSSSCG00000032262; Expressed in granulosa cell and 40 other cell types or tissues.
DR GO; GO:0003940; F:L-iduronidase activity; IBA:GO_Central.
DR GO; GO:0030209; P:dermatan sulfate catabolic process; IEA:Ensembl.
DR GO; GO:0030211; P:heparin catabolic process; IEA:Ensembl.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR049165; GH39_as.
DR InterPro; IPR049167; GH39_C.
DR InterPro; IPR049166; GH39_cat.
DR InterPro; IPR000514; Glyco_hydro_39.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR12631; ALPHA-L-IDURONIDASE; 1.
DR PANTHER; PTHR12631:SF8; ALPHA-L-IDURONIDASE; 1.
DR Pfam; PF01229; Glyco_hydro_39; 1.
DR Pfam; PF21200; Glyco_hydro_39_C; 1.
DR PRINTS; PR00745; GLHYDRLASE39.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
DR PROSITE; PS01027; GLYCOSYL_HYDROL_F39; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..643
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014582352"
FT DOMAIN 29..524
FT /note="Glycosyl hydrolases family 39 N-terminal catalytic"
FT /evidence="ECO:0000259|Pfam:PF01229"
FT DOMAIN 552..639
FT /note="Alpha-L-iduronidase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21200"
FT ACT_SITE 181
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600514-1"
SQ SEQUENCE 643 AA; 71610 MW; 7B83014CD5887DF8 CRC64;
MRPPRPHASL LELLGVLLAA SLAAAEAPHL VRVDAARALG PLRPFWRSTG FCPPLPHSQA
HRYDLSWDQQ LNLAYVGAVP HGGIQQVRAH WLLGLVTARR SAGQGLSYNF THLDRYLDLL
RENQLLPGFE LMGSPSGHFT DFEDKQQVFE WRNLVSLLAR RYVGRYGLKH VSKWNFETWN
EPDHHDFDNV SMTLQGFLNY YDACSEGLRA ASPALRLGGP GDSFHDPPRS PLCWGLLAHC
HNGTNFFTGE VGVRLDFIAL HKKGAGSSIY ILEQEVAVMQ QIQRLFPKFT DTPIYNDEAD
PLVGWSLPQP WRADVTYAAM VVKVIAQHQN LLVANTSSSI RYTLLSNDNA FLSYHPHPFS
QRTLTARFQV NNTRPPHVQL LRKPVLTAMG LLALLDSEQL WAEVSQAGRV LDSNHTVGVL
ASAHRPTGPA DAWRATVLVY ASDDTRAHAN RSVPLILSLH GVPPGPGLVF VQLYMDNSIS
SPDGEWRRLG RPVFPSAQQL RRMRAAEDPA AVRPLPFPPS GRLTLSPELP LPSLLLVHVC
ARPEAPPGQV SRLRALPLTR GQLLLVWSDE RVGSKCLWDY EIQFCPEGGV YTRVDRKPST
FNLFVFSPDT AVVSGSYRVR AVDYWARPGP FSSPVRYLEV PAG
//