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Database: UniProt
Entry: M3VUC1_FELCA
LinkDB: M3VUC1_FELCA
Original site: M3VUC1_FELCA 
ID   M3VUC1_FELCA            Unreviewed;      1787 AA.
AC   M3VUC1;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   25-OCT-2017, entry version 40.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN11A {ECO:0000313|Ensembl:ENSFCAP00000000217};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000000217, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000000217, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000217,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000000217}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000217};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000000217}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000217};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSFCAP00000000217}.
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DR   EMBL; AANG02186569; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02186570; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02186571; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02186572; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02186573; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02186574; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02186575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9685.ENSFCAP00000000217; -.
DR   Ensembl; ENSFCAT00000000236; ENSFCAP00000000217; ENSFCAG00000000236.
DR   eggNOG; ENOG410INF8; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; M3VUC1; -.
DR   OMA; CYQIVKH; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000011712; Chromosome C2.
DR   Bgee; ENSFCAG00000000236; -.
DR   GO; GO:0044299; C:C-fiber; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0051930; P:regulation of sensory perception of pain; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028821; Na_channel_a11su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF210; PTHR10037:SF210; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    134    154       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    166    187       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    199    215       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    236    257       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    263    282       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    377    396       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    582    600       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    612    635       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    647    667       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    705    728       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    787    812       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1057   1075       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1096   1115       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1121   1140       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1166   1192       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1287   1310       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1360   1383       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1403   1421       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1433   1451       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1488   1516       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1536   1559       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1580   1606       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      134    413       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      582    821       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      829   1051       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1055   1319       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1367   1616       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      407    438       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1787 AA;  203612 MW;  E0264D0602E3AA9A CRC64;
     MDDRCYPVIF PDERNFRPFT SDTLATIEKR IAIQKEKKKC KDQTPAEPQP RPQLDLKVSR
     KLPKLYGNIP HELIARPLED LDPFYRNHKT FMVLNKKRTI YRFSANRALF VFGPFNPIRS
     LAIRISVHST AVTLFSMFII CTVIINCVFM ATACGKDNSN IYTDNAEYVF TGIYIFEALI
     KILARGFVLD EFSFLRDPWN WLDSIVIATA FVSYSPSIRA SGISLSSLRT FRVFRALKAI
     SVVSGLKVIV GALLRSVKKL VDVMILTLFC LSIFALVGQQ LFKENLNQRC VRKDCKDMDN
     LDDHCFEKKD STEFRICGSW MGESACSEQF QCNHTKRNPD YNYTNFDNFG WSFLSMFRLI
     TQDSWEKLYQ QTLRTSGLFS VFFFVVVIFL GSFYLINLTL AVVTMAYEEQ NRNVAAETEA
     KEKMFQEAQR LLKEEKEALV AMGIDRSSLN SLEASSFSPK KRKLFGNRKR KSFILRDSGK
     DQPPESDSDE DSTKKPHILE QTKRLSQNLS VDFCDEHGDP FQRQRALSAV SILTITMQEQ
     EKSQEPCLPC GGNVASRYLV WNCSPQWLCI KKALRVVMTD PFTELVITIC IVINTVFLAL
     EHYKMDQSFE YMLYTGNLVF TGIFMAEMCL KIIALDPYNY FRRGWNIFDS IVALLSFADV
     MNSVVVGKQS PLFFHSLRVL RVFKLAKSWP TLNTLIKIIG HSVGALGNLT VVLAIVVFIF
     SVVGMQLFGS KFNSVRNNTK SCGPTVPCLR RWHMGDFYRS FLVVFRILCG EWIENMWECM
     QETSKPLCVV VFLLIMVIGK LVVLNLFIAL LLNSFSNEER DGSLDGEQKT KVQLALDRFH
     RAFCFVIHTL ARFCHTWCRR QTLPQQKEVS GDPPAKSKDI IPLVAGVKRG SETWEEFGVV
     TSAPKTLSVE HDRTWLAPLA EEEDDFESSG KINAQCIAPP EAGKQAYELP QETKTSTSPG
     AQSVEIDVFS EGDIYLSAQN TRKKSDTTSV FSECSTIDPQ DPFARVPEMV PKKEPERCFP
     KGLGHCFPCC ATDKRKSHWI IWWNLRKTCY QIVKHSWFES FVIFVILLSS GALVFEDIHL
     EKRPNIQALL NCTDHIFTYI FILEMGLKWV AFGFGKYFTS VWCWLDFIIV IVSVTSLIDL
     KSLKSFRTLR ALRPLRALSQ FEGMKVVVNA LIGAIPAILN VLLVCLIFWL IFCILGVNFF
     SGKFGRCINV SDTNSVINYS VVANQSQCES GNFSWVTPPV NFDNVGMAYL ALLQVATFKG
     WMDIMYAAVD SRGKELQPGF EENPQNYLFF VAFIIFGSFF TLNLFIGVII DNFNQQQKKL
     GGEDIFMTEE QKKYYNAMKK LGSKKPQKPI PRPLNKCQGL AFDLVTNQVF DVIIIILIFL
     NMVIMMAESN NHPEDTKAIL EELNLAFVVI FTIECLIKIF ALRQYYFTNG WNLFDCVIVV
     LSIVSAMVSA LENQQHIPFP PTLFRVVRLA RIGRILRLVR AARGIRTLLF ALMMSLPSLF
     NIGLLLFLVM FIYAIFGMNC FCKVKEGFGI DDIFNFKTFV GSILCLFQIT TSAGWDALLR
     PMLQSNDSCN PNLDSRHLPA IAIAYFVSYI IISFLIVVNM YIAVILENFN TATEESEDPL
     GEDDFEIFYE VWEKFDPEAT QFIKYPALSD FADALPEPLR VAKPNRFQFL MMDLPMVSGD
     RLHCLDILFA FTTRVLGNSS GLDSMKAMME EKFMEANPSK KLYEPIVTTT KRKEEERCAA
     VIQKAFRKYK LKMSMGALED GPRSPLQTLC NGDLSSSGVA EGKVHYD
//
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