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Database: UniProt
Entry: M3VUJ2_FELCA
LinkDB: M3VUJ2_FELCA
Original site: M3VUJ2_FELCA 
ID   M3VUJ2_FELCA            Unreviewed;       411 AA.
AC   M3VUJ2;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 3.
DT   24-JAN-2024, entry version 67.
DE   SubName: Full=Napsin A aspartic peptidase {ECO:0000313|Ensembl:ENSFCAP00000000296.5};
GN   Name=NAPSA {ECO:0000313|Ensembl:ENSFCAP00000000296.5,
GN   ECO:0000313|VGNC:VGNC:63723};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000000296.5, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000000296.5, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000296.5,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA   Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA   Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA   Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000000296.5, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000296.5,
RC   ECO:0000313|Proteomes:UP000011712};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000000296.5}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000296.5};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR   EMBL; AANG04000747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; M3VUJ2; -.
DR   MEROPS; A01.046; -.
DR   Ensembl; ENSFCAT00000000323.6; ENSFCAP00000000296.5; ENSFCAG00000000324.6.
DR   VGNC; VGNC:63723; NAPSA.
DR   eggNOG; KOG1339; Eukaryota.
DR   GeneTree; ENSGT00940000160179; -.
DR   HOGENOM; CLU_013253_3_3_1; -.
DR   Proteomes; UP000011712; Chromosome E2.
DR   Bgee; ENSFCAG00000000324; Expressed in adult mammalian kidney and 9 other cell types or tissues.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.70.10; Acid Proteases; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR47966:SF51; NAPSIN-A; 1.
DR   Pfam; PF00026; Asp; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 2.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU000454};
KW   Protease {ECO:0000256|RuleBase:RU000454};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT   DOMAIN          65..386
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   REGION          27..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          391..411
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        83
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   ACT_SITE        270
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   DISULFID        96..103
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT   DISULFID        261..265
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ   SEQUENCE   411 AA;  44270 MW;  D26F8EF1CC22790E CRC64;
     MQVFLPSLVS CSRGWIPLRR VHTGHRTLNP PRGWGKPAAT PALGAPSPGD NPTVIPLSNY
     MNVQYYGEIG LGTPPQNFSV VFDTGSSNLW VPSIRCHFFS LPCWLHHRFN PKASSSFQPN
     GTKFDIQYGT GRLAGILSED KLTIGGMMNA SVIFGEALWE SSLVFTLARF DGILGLAFPV
     LAVGGVRPPL DVLVDQGLLD KPVFSFYLNR DPEAADGGEL VLGGSDPAHY IPPLTFVPVT
     IPAYWQIHME RMKVGTGLTL CAQGCAAILD TGTSLITGPT EEIRALNTAI GGISLLVGEY
     LIQCETIPTL PPVSFLLGGV WFNLTAQDYV IQIVRGGFRL CLSGFQALDM PSPAGPLWIL
     GDVFLRTYVA VFDRGNLTSE ARVGLARSRF GETGPRRGGP AQAQFSGWPL G
//
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