ID M3VUJ2_FELCA Unreviewed; 411 AA.
AC M3VUJ2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 24-JAN-2024, entry version 67.
DE SubName: Full=Napsin A aspartic peptidase {ECO:0000313|Ensembl:ENSFCAP00000000296.5};
GN Name=NAPSA {ECO:0000313|Ensembl:ENSFCAP00000000296.5,
GN ECO:0000313|VGNC:VGNC:63723};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000000296.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000000296.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000296.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000000296.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000296.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000000296.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000296.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR EMBL; AANG04000747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3VUJ2; -.
DR MEROPS; A01.046; -.
DR Ensembl; ENSFCAT00000000323.6; ENSFCAP00000000296.5; ENSFCAG00000000324.6.
DR VGNC; VGNC:63723; NAPSA.
DR eggNOG; KOG1339; Eukaryota.
DR GeneTree; ENSGT00940000160179; -.
DR HOGENOM; CLU_013253_3_3_1; -.
DR Proteomes; UP000011712; Chromosome E2.
DR Bgee; ENSFCAG00000000324; Expressed in adult mammalian kidney and 9 other cell types or tissues.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF51; NAPSIN-A; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 2.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 65..386
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT REGION 27..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 391..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 83
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 270
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 96..103
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 261..265
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 411 AA; 44270 MW; D26F8EF1CC22790E CRC64;
MQVFLPSLVS CSRGWIPLRR VHTGHRTLNP PRGWGKPAAT PALGAPSPGD NPTVIPLSNY
MNVQYYGEIG LGTPPQNFSV VFDTGSSNLW VPSIRCHFFS LPCWLHHRFN PKASSSFQPN
GTKFDIQYGT GRLAGILSED KLTIGGMMNA SVIFGEALWE SSLVFTLARF DGILGLAFPV
LAVGGVRPPL DVLVDQGLLD KPVFSFYLNR DPEAADGGEL VLGGSDPAHY IPPLTFVPVT
IPAYWQIHME RMKVGTGLTL CAQGCAAILD TGTSLITGPT EEIRALNTAI GGISLLVGEY
LIQCETIPTL PPVSFLLGGV WFNLTAQDYV IQIVRGGFRL CLSGFQALDM PSPAGPLWIL
GDVFLRTYVA VFDRGNLTSE ARVGLARSRF GETGPRRGGP AQAQFSGWPL G
//