ID M3VV26_FELCA Unreviewed; 1508 AA.
AC M3VV26;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 24-JAN-2024, entry version 65.
DE SubName: Full=Gem nuclear organelle associated protein 5 {ECO:0000313|Ensembl:ENSFCAP00000000553.5};
GN Name=GEMIN5 {ECO:0000313|Ensembl:ENSFCAP00000000553.5,
GN ECO:0000313|VGNC:VGNC:62515};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000000553.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000000553.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000553.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000000553.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000553.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000000553.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000553.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04003171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9685.ENSFCAP00000000553; -.
DR PaxDb; 9685-ENSFCAP00000000553; -.
DR Ensembl; ENSFCAT00000000595.6; ENSFCAP00000000553.5; ENSFCAG00000000595.6.
DR VGNC; VGNC:62515; GEMIN5.
DR eggNOG; ENOG502QPYZ; Eukaryota.
DR GeneTree; ENSGT00620000088064; -.
DR HOGENOM; CLU_004491_0_1_1; -.
DR InParanoid; M3VV26; -.
DR OMA; YWFNRND; -.
DR Proteomes; UP000011712; Chromosome A1.
DR Bgee; ENSFCAG00000000595; Expressed in embryonic head and 10 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0032797; C:SMN complex; IBA:GO_Central.
DR GO; GO:0034718; C:SMN-Gemin2 complex; IEA:Ensembl.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR GO; GO:0043022; F:ribosome binding; IEA:Ensembl.
DR GO; GO:0000340; F:RNA 7-methylguanosine cap binding; IEA:Ensembl.
DR GO; GO:0030619; F:U1 snRNA binding; IEA:Ensembl.
DR GO; GO:0030621; F:U4 snRNA binding; IEA:Ensembl.
DR GO; GO:0030622; F:U4atac snRNA binding; IEA:Ensembl.
DR GO; GO:0006417; P:regulation of translation; IEA:Ensembl.
DR GO; GO:0000387; P:spliceosomal snRNP assembly; IBA:GO_Central.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46362; GEM-ASSOCIATED PROTEIN 5; 1.
DR PANTHER; PTHR46362:SF1; GEM-ASSOCIATED PROTEIN 5; 1.
DR Pfam; PF12894; ANAPC4_WD40; 3.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 13.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 60..104
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 117..204
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 241..264
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 394..479
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT DOMAIN 540..588
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 635..668
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 715..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1311..1342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1388..1431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..735
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..769
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1311..1331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1508 AA; 168117 MW; 7D9318189D41F0FA CRC64;
MGQEPRTLPP SPNWYCARCS DAVPGGLFGF AARTSVFLVR VGPGAGAIPG TPPFRVIGEL
VGHTERVSGF TFSHHPGQYN LCATSSDDGT VKIWDVETKA VVTEHALHQH TISALHWSPQ
VKDLIVSGDE KGVVFCYWLN RNDSQHLFIE PRTIFCLTCS PHHEDLVAIG YKDGIVVIID
ISKKGEVIHR LRGHDDEIHS IAWCPLPGED CLSISQEENS EEPAIPNGKV TAQTPVTKGC
YLATGSKDQT IRIWSCSRGR GVMVLKLPFL KRRGGGIDPT IKERLWLTLH WPKDQPTQLV
SSCFGGELLL WDLTQSWRRK YTLFSASSEG QNHSRIVFNL CPLQTEDDKQ LLLSTSMDRD
VKCWDMATLE CCWSLPSLGG FAYSLAFSPV DMGCLAIGVG DGMIRVWNTL SIKNNYDVKN
FWQGVKSKVT ALCWHPTKEG CLAFGTDDGK VGLYDTYSNK PPQISSTYHK KTVYTLAWGP
PLPPISLGGE GDRPSLTLYS CGGEGIVLQH NPWKLGGEAY DINKLIRDTN SIKYKLPVHT
EVSWKADGKI MALGNEDGSI EIFQVPNLKL ICTIQQHHKL VNTISWHHEH GSQPELSYLM
ASGSNNAVIY VHNLKTVIES NPESPVTITE PYRTLSGHTA KITSVAWSPH HDGRLVSASY
DGTAQVWDTL REEPLCNFRG HRGRLLCVAW SPLDPDCIYS GADDFCVYKW LTPMQEHSRP
PQGKKSIELE KKRLSQPKPK PKKKKKPTSR APVKQDVYDG NEDESIRESS GPVENGLSDQ
EGEEEAREPE LPSSIISVAS REPVTCTPVS IGFEKSKITV NNKVTILKKE PPKEKSESIT
KKRKARSMLP LTTSLDHRSK EELHQDCLVL ATAKHSKELN EDVSADLEER FHLGLFTDRT
ALYRMIEVEG KGHLENGHPE LFHQLMLWKG DLKGVLQTAA ERGELTDSLV AMAPVAGYHV
WLWAVEAFAK QLCFQDQYVK AASHLLSIHK VYEAVELLRS NHFYREAIAV AKARLRPEDP
ILKDLYLTWG AILEKDGHYA VAAKCYLGAA SAYDAAKVLS KKGDAASLKT AAELASIVGE
NELSSSLALR CAQELLLARN WVGAQEALKL HESLKGQRLV FCLLELLSKR LEERQLSEGK
SSSYNVWAAG TEGPFVERVT AVWKSTFSLE TPEQYQAALQ QLQTIKYPSA TNNTPSKQLL
LHICHDLTLA VLSQQVASWD VAVEALLRAV VRSYDSGNFT IMQEVHSAFL PEGCDHLRDK
LGEHQSPTTP AFKSLEAFFI YGRLYEFWWS LSKPCPKSSV WVRAAHGRTT SVEQSQQIDS
ASPEETDPNI SQPKPSGPPE LDLSLTEESE QMLITCKELF SEKHASLQNS QRTVAEVQET
LAEMIRQHQK SQVCKSTTNG PDKNESEQVA EQPLSSPQNQ CKEEKNQPLS LPELTKSLTE
ANERIAKFPE SVKIWPFPDV LECCLILLHI GAQCPGSVTQ DMQQQAQELL QKYGNTKVYR
RYCQTFCT
//
