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Database: UniProt
Entry: M3VW81_FELCA
LinkDB: M3VW81_FELCA
Original site: M3VW81_FELCA 
ID   M3VW81_FELCA            Unreviewed;      2234 AA.
AC   M3VW81;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-SEP-2017, entry version 34.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1B {ECO:0000313|Ensembl:ENSFCAP00000001128};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000001128, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000001128, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000001128,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000001128}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000001128};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000001128}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000001128};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSFCAP00000001128}.
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DR   EMBL; AANG02005476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02005477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02005496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02005507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02005517; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02005528; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02005535; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02005536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02005537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9685.ENSFCAP00000001128; -.
DR   Ensembl; ENSFCAT00000001217; ENSFCAP00000001128; ENSFCAG00000001217.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; M3VW81; -.
DR   OMA; DSPRNNA; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   Proteomes; UP000011712; Chromosome D4.
DR   Bgee; ENSFCAG00000001217; -.
DR   GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0007269; P:neurotransmitter secretion; IEA:Ensembl.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:Ensembl.
DR   GO; GO:0051924; P:regulation of calcium ion transport; IEA:Ensembl.
DR   GO; GO:0008016; P:regulation of heart contraction; IEA:Ensembl.
DR   GO; GO:0048265; P:response to pain; IEA:Ensembl.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF246; PTHR10037:SF246; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     12     29       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     50     71       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     83    103       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    138    160       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    215    236       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    248    270       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    400    420       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    426    443       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    525    547       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    603    625       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1046   1064       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1084   1104       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1116   1135       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1181   1203       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1293   1318       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1374   1392       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1404   1427       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1439   1463       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1484   1513       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1582   1605       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1621   1656       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      628    654       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2234 AA;  250052 MW;  6C4B2FF118889F0F CRC64;
     TSWPVLNPRT PFEYMILATI IANCIVLALE QHLPDGDKTP MSERLDDTEP YFIGIFCFEA
     GIKIIALGFV FHKGSYLRNG WNVMDFVVVL TGILATAGTD FDLRTLRAVR VLRPLKLVSG
     IPSLQVVLKS IMKAMVPLLQ IGLLLFFAIL MFAIIGLEFY MGKFHKACFP NSTDPEPVGD
     FPCGKEAPAR LCEGDTECRE YWPGPNFGIT NFDNILFAIL TVFQCITMEG WTDILYNTND
     AAGNTWNWLY FIPLIIIGSF FMLNLVLGVL SGEFAKERER VENRRAFLKL RRQQQIEREL
     NGYLEWIFKA EEVMLAEEDK NAEEKSPLDA VLKRAATKKS RNDLIHAEEG EDRFADLCAV
     GSPFARASLK SGKTESSSYF RRKEKMFRFF IRRMVKAQSF YWVVLCVVAL NTLCVAMVHY
     NQPQRLTTAL YFAEFVFLGL FLTEMSLKMY GLGPRSYFRS SFNCFDFGVI VGSIFEVVWA
     AIKPGTSFGI SVLRALRLLR IFKVTKYWSS LRNLVVSLLN SMKSIISLLF LLFLFIVVFA
     LLGMQLFGGQ FNFQDETPTT NFDTFPAAIL TVFQILTGED WNAVMYHGIE SQGGVSKGMF
     SSFYFIVLTL FGNYTLLNVF LAIAVDNLAN AQELTKDEEE MEEAANQKLA LQKAKEVAEV
     SPMSAANISI AAARPQNSAK ARSVWEQRAS QLRLQNLRAS CEALYSEMDP EERLRYATTR
     HLRPDMKTAA PGPAPGRPAA ARSRRGGTGP GTRRCPRTRT RRRRARSRTG TRRRSSGTIS
     PSEGVRVAEA GPCRGARGWG CRWRRVQGCG AVPVQVCLVR VRRYSKAGRR ERVSDEIAGT
     GLGHVGLEGI GPGWVAMTER ASQLSTPAGS PAPWQGQAMT LSLHSVMPAM PGRVPGTDRL
     SRPHFYFSDL NTQKCTNREP RCDLEASEMM GVGPVHALPS TCLQKVEEQP EDADNQRNVT
     RMGSQPSDLS ATVHIPVTLT GPPGETTVVP SGNVDLESQA EGKKEVEADD VMRSGPRPIV
     PYSSMFCLSP TNLLRRFCHY IVTMRYFEMV ILVVIALSSI ALAAEDPVRT DSPRNNALKY
     MDYIFTGVFT FEMVIKMIDL GLLLHPGAYF RDLWNILDFI VVSGALVAFA FSSFMGGSKG
     KDINTIKSLR VLRVLRPLKT IKRLPKLKAV FDCVVNSLKN VLNILVVYML FMFIFAVIAV
     QLFKGKFFYC TDESKGLERD CRGQYLDYEK EEVEAQPRQW KKYDFHYDNV LWALLTLFTV
     STGEGWPMVL KHSVDATYEE QGPSPGYRME LSIFYVVYFV VFPFFFVNIF VALIIITFQE
     QGDKVMSECS LEKNERACID FAISAKPLTR YMPQDKQSFQ YKTWTFVVSP PFEYFIMAMI
     ALNTVVLMMK FYNAPYEYEL MLKCLNIVFT SMFSMECVLK IIAFGVLNYF RDAWNVFDFV
     TVLGSITDIL VTEIANNFIN LSFLRLFRAA RLIKLLRQGY TIRILLWTFV QSFKALPYVC
     LLIAMLFFIY AIIGMQVFGN IALDDDTSIN RHNNFRTFLQ ALMLLFRSAT GEAWHEIMLS
     CLSNQACDEH ANANECGSDF AYFYFVSFIF LCSFLMLNLF VAVIMDNFEY LTRDSSILGP
     HHLDEFIRVW AEYDPAACGR ISYNDMFEML KHMSPPLGLG KKCPARVAYK RLVRMNMPIS
     NEDMTVHFTS TLMALIRTAL EIKLAPAGTK QHQCDAELRK EISSVWANLP QKTLDLLVPP
     HKPDEMTVGK VYAALMIFDF YKQNKTTRDQ IHQATGGLSQ MGPVSLFHPL KATLEQTQPA
     VLRGARVFLR QKSSASLSNG GAVQTQESGI KESVSWGTQR TQEVPYEART PLERGHSTEI
     PAVHPGKPAV DVQMQSMALR GPDGEPQPGL ESQGRAASMP RLAAETQPAP DASPMKRSIS
     TLAPQRPHVA HLCNAALDRA PASQAVPHHH HRCHRRRDRK QKSLEKGPSL SADADGAPSS
     AAGPGPPPGE GPTGCRRERR QERGRSQERR QPSSSSSEKQ RFYSCDRFGG REPLQPKPSL
     SSHPTSPTAG QEPGPPRQGG GSVNGSPLLS TSGASTPGRG GRRQLPQTPL TPRPSVTYKT
     ANSSPVHFAG AQTSLPTFSP GRLSRGLSEH NALLQRDPLS QPLAAGSRIG SDPYLGQRLD
     SEDTVRAQPE DTLTFEEAVA TNSGRSSRTS YVSSLTSQSH PLRRVPNGYH CTLGLSSGGR
     VRHSYHHPDQ DHWC
//
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