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Database: UniProt
Entry: M3VXS5_FELCA
LinkDB: M3VXS5_FELCA
Original site: M3VXS5_FELCA 
ID   M3VXS5_FELCA            Unreviewed;       990 AA.
AC   M3VXS5;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 4.
DT   24-JAN-2024, entry version 65.
DE   SubName: Full=NLR family pyrin domain containing 9 {ECO:0000313|Ensembl:ENSFCAP00000001890.6};
GN   Name=NLRP9 {ECO:0000313|Ensembl:ENSFCAP00000001890.6,
GN   ECO:0000313|VGNC:VGNC:63833};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000001890.6, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000001890.6, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000001890.6,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA   Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA   Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA   Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000001890.6, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000001890.6,
RC   ECO:0000313|Proteomes:UP000011712};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000001890.6}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000001890.6};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the NLRP family.
CC       {ECO:0000256|ARBA:ARBA00008665}.
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DR   EMBL; AANG04003316; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; M3VXS5; -.
DR   STRING; 9685.ENSFCAP00000001890; -.
DR   PaxDb; 9685-ENSFCAP00000001890; -.
DR   Ensembl; ENSFCAT00000002044.6; ENSFCAP00000001890.6; ENSFCAG00000002042.6.
DR   VGNC; VGNC:63833; NLRP9.
DR   eggNOG; KOG4308; Eukaryota.
DR   GeneTree; ENSGT00940000163218; -.
DR   HOGENOM; CLU_002274_2_1_1; -.
DR   InParanoid; M3VXS5; -.
DR   OMA; PWIDEEY; -.
DR   Proteomes; UP000011712; Chromosome E2.
DR   GO; GO:0061702; C:canonical inflammasome complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0050727; P:regulation of inflammatory response; IBA:GO_Central.
DR   CDD; cd08320; Pyrin_NALPs; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR004020; DAPIN.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR   PANTHER; PTHR45690:SF13; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 9; 1.
DR   Pfam; PF13516; LRR_6; 3.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   Pfam; PF02758; PYRIN; 1.
DR   SMART; SM00368; LRR_RI; 8.
DR   SMART; SM01289; PYRIN; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS50824; DAPIN; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   3: Inferred from homology;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT   DOMAIN          1..94
FT                   /note="Pyrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50824"
FT   DOMAIN          144..342
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
SQ   SEQUENCE   990 AA;  113575 MW;  3335E5211AEBA0FD CRC64;
     MAESFFSDFG LLWYLEELRK EEFWKFKELL KQEPLQLELK PIPWTELKKA SREDVAKLLG
     KHYPGKQAWE LTLNLFLQIE RRDLWTKAQE EIRNKPNPYR NHMREKFRLI WEKETCLPVP
     SDFYKETTKN EYETLKAAYP ARLPTVVLQG PEGIGKTTLL RKAVLEWAEG NLWKDRFAFI
     FFLNGCEMNA IAETSLVELI SRDWPQSSEP VEDIFSQPER ILFIMDGFEE LKFDLEITTQ
     LCDDQKQRKP MQIIVRSLLQ RKMLPKSSLL VALGTVGMRR YYFLLQHPKY IVLPGFSHHE
     RKLYFYHFFR ERSKAMKAFS FVRDNVPLCM FCHNPLVCWL VCTCMKWQLE KGKDLEVASE
     STTSLYASFL INVFKSRNEN CPPKQSRARL KGLCTLAAEG IWTRTFVFCH GDLRRSGVSE
     SDTLMWVGMR LLLRNGHCFT FKHLCIQEFC AAMFYLLRQP EDNPDPAIGS VTQLVTAGVS
     RVQSHLSQMI TFLFGVSTGK ITNMLETSFG FLLSKEIRQE ITQCLKSLSQ CDTNQVVVNF
     QELFSGLFET HEKEFVRQVM DFFEEVDIYI GNIEELVISA FCMKHCQNLQ KLHLSIENVF
     SDDSGSITND EEKLSFWKDL CSVFTANKNF QMLDLDNCMF DEPSLEILWK ALAHPVCKLQ
     KFGYNFASYV GNGPDFFEAI LHNPYLKCLN LHGTRLSLMN VRQLCETLKH PVCIVEQLML
     GRCDITAKAC DDIASVLVCN KNLKLLSLVE NPLRNEGMLM LCDALKHPDC ALETLLLMCC
     GLTSVACDYL SQALVYNTSL SVLDLESNLL EDSGVASLCE ALKHPNCNIE QLWLSDCYLT
     PLCCKHLSAV LVCNEKLKTL KLGSNDIQDA GVKELCEALK HPNCKVETLG LEICHLTTAC
     CEALASALTG CKSLRNLNLD WISLDHDGAV VLCEAMCHLD CTLQRLGLDK SAFDEETQML
     LTAVEEKNPH LTISHQLWVN EEYRVRGVLS
//
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