ID M3VXS5_FELCA Unreviewed; 990 AA.
AC M3VXS5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 24-JAN-2024, entry version 65.
DE SubName: Full=NLR family pyrin domain containing 9 {ECO:0000313|Ensembl:ENSFCAP00000001890.6};
GN Name=NLRP9 {ECO:0000313|Ensembl:ENSFCAP00000001890.6,
GN ECO:0000313|VGNC:VGNC:63833};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000001890.6, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000001890.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000001890.6,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000001890.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000001890.6,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000001890.6}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000001890.6};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR EMBL; AANG04003316; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3VXS5; -.
DR STRING; 9685.ENSFCAP00000001890; -.
DR PaxDb; 9685-ENSFCAP00000001890; -.
DR Ensembl; ENSFCAT00000002044.6; ENSFCAP00000001890.6; ENSFCAG00000002042.6.
DR VGNC; VGNC:63833; NLRP9.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00940000163218; -.
DR HOGENOM; CLU_002274_2_1_1; -.
DR InParanoid; M3VXS5; -.
DR OMA; PWIDEEY; -.
DR Proteomes; UP000011712; Chromosome E2.
DR GO; GO:0061702; C:canonical inflammasome complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0050727; P:regulation of inflammatory response; IBA:GO_Central.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF13; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 9; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM00368; LRR_RI; 8.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 1..94
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 144..342
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 990 AA; 113575 MW; 3335E5211AEBA0FD CRC64;
MAESFFSDFG LLWYLEELRK EEFWKFKELL KQEPLQLELK PIPWTELKKA SREDVAKLLG
KHYPGKQAWE LTLNLFLQIE RRDLWTKAQE EIRNKPNPYR NHMREKFRLI WEKETCLPVP
SDFYKETTKN EYETLKAAYP ARLPTVVLQG PEGIGKTTLL RKAVLEWAEG NLWKDRFAFI
FFLNGCEMNA IAETSLVELI SRDWPQSSEP VEDIFSQPER ILFIMDGFEE LKFDLEITTQ
LCDDQKQRKP MQIIVRSLLQ RKMLPKSSLL VALGTVGMRR YYFLLQHPKY IVLPGFSHHE
RKLYFYHFFR ERSKAMKAFS FVRDNVPLCM FCHNPLVCWL VCTCMKWQLE KGKDLEVASE
STTSLYASFL INVFKSRNEN CPPKQSRARL KGLCTLAAEG IWTRTFVFCH GDLRRSGVSE
SDTLMWVGMR LLLRNGHCFT FKHLCIQEFC AAMFYLLRQP EDNPDPAIGS VTQLVTAGVS
RVQSHLSQMI TFLFGVSTGK ITNMLETSFG FLLSKEIRQE ITQCLKSLSQ CDTNQVVVNF
QELFSGLFET HEKEFVRQVM DFFEEVDIYI GNIEELVISA FCMKHCQNLQ KLHLSIENVF
SDDSGSITND EEKLSFWKDL CSVFTANKNF QMLDLDNCMF DEPSLEILWK ALAHPVCKLQ
KFGYNFASYV GNGPDFFEAI LHNPYLKCLN LHGTRLSLMN VRQLCETLKH PVCIVEQLML
GRCDITAKAC DDIASVLVCN KNLKLLSLVE NPLRNEGMLM LCDALKHPDC ALETLLLMCC
GLTSVACDYL SQALVYNTSL SVLDLESNLL EDSGVASLCE ALKHPNCNIE QLWLSDCYLT
PLCCKHLSAV LVCNEKLKTL KLGSNDIQDA GVKELCEALK HPNCKVETLG LEICHLTTAC
CEALASALTG CKSLRNLNLD WISLDHDGAV VLCEAMCHLD CTLQRLGLDK SAFDEETQML
LTAVEEKNPH LTISHQLWVN EEYRVRGVLS
//