ID M3VZE6_FELCA Unreviewed; 1844 AA.
AC M3VZE6;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=NLR family CARD domain containing 5 {ECO:0000313|Ensembl:ENSFCAP00000002699.6};
GN Name=NLRC5 {ECO:0000313|Ensembl:ENSFCAP00000002699.6,
GN ECO:0000313|VGNC:VGNC:63828};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000002699.6, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000002699.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000002699.6,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000002699.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000002699.6,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000002699.6}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000002699.6};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04002512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_011288452.1; XM_011290150.2.
DR STRING; 9685.ENSFCAP00000002699; -.
DR PaxDb; 9685-ENSFCAP00000002699; -.
DR Ensembl; ENSFCAT00000002930.6; ENSFCAP00000002699.6; ENSFCAG00000002930.6.
DR VGNC; VGNC:63828; NLRC5.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00940000160652; -.
DR HOGENOM; CLU_002522_1_0_1; -.
DR InParanoid; M3VZE6; -.
DR OMA; AQQDETW; -.
DR OrthoDB; 3512553at2759; -.
DR Proteomes; UP000011712; Chromosome E2.
DR Bgee; ENSFCAG00000002930; Expressed in spleen and 7 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR GO; GO:0045087; P:innate immune response; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR GO; GO:0060339; P:negative regulation of type I interferon-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0045345; P:positive regulation of MHC class I biosynthetic process; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060340; P:positive regulation of type I interferon-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0060335; P:positive regulation of type II interferon-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR Gene3D; 1.10.533.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 5.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041210; NLRC5_atypical_Card.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF281; PROTEIN NLRC5; 1.
DR Pfam; PF18461; Atypical_Card; 1.
DR Pfam; PF13516; LRR_6; 6.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR SMART; SM00367; LRR_CC; 8.
DR SMART; SM00368; LRR_RI; 16.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 3.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 228..361
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 102..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1844 AA; 202095 MW; F548ECE6E081482F CRC64;
MDPVSLQLGT KNLWSLLVRL LSKDPQWLNA KVKFFLPKMD LSSRNKAEDA TQGVMLQLNR
LHTQGQATWQ AFIHCVCMEL DVPLDLEVPL LSTWGHGDGF ASQLETGEES PPESQLHHGL
KRPHQSCGSS PRPKQCRKQQ LGGYEELAKR YLQLLRSSAQ QRYGSRTRRP GQPLAFHQAY
IPPILQWSRA TAPFNTQEGA ILGDPKAEDG TEASILDLFN TKADKGPRVT VLLGKAGMGK
TTLAHRLCQK WADGQLDRFQ ALFLFEFRQL NLITEFLTLP QLLFDLYLSP EAGPDLVFQY
LEENAKGVLL IFDGLDQALH PPSSKDTAGP EAPSPALALF SGLCKGTLLP GCWVLATSRP
GKLPDCLPTE AAMVHMWGFD RPRVEEYVGR FFSNQPWQEA ALAELRENRH LQSMCAVPAV
CQVTCLCLYH LLPSSSPGQS AALLPTVTQN YVQMVSTLGP RGHLLPESLL GLSEVALRGL
ETGKVIFSVG DIPPPMMAFG AALGLLTSFC ICTGPGHQET GYAFTHLSLQ EFFAALHLMA
SPEVDKNALA HYVTLSSHWV LRTKARLGLL DHLPTFLAGL ASRACCPFLS HVAQRDEVWV
GARQAEVMQA LRKLATRRLT GPKVVALCHC VGETQEPELA SLMAQSLPCH LSFHNFPLTY
ADLASLNNIL GHRNAPIQLD FEGCPLEPHC PEALAGCKQV ENLSFKSRKC GDAFAEALSR
SLPTMGSLKK LGLAGSKITA RGIGRLVQAL PLCPQLEEVS FQDNQLKDGV LLNIVEVLLC
LPRLQKLDLS RNSVSMSTLL CLTKVAITSP AVRMLQVREA DLIFLLSPPT ETAAELQGAS
DLQGNASQRK EAQSRSLALR LQQCQLRVHD VQELIAQLQE GPHLDKVDLS GNQLDNEGCR
LMAEAAAQLD ITRNLDLSDN GLSVDGVDGV LSAVSMCQTL AELHISLLHK TVVLTFAPKQ
EEQGGIQERA ALHDGLMRQM PCELPPHSTR IRLTHCGLQA KHLAQLCRAL GGSCRLSHLD
FSGNALGDEG VAQLAQLLPG LGTLQSLNLS ENGLSLDSVF ILTQCFSTLQ WLFHLEVNSE
SQHVVLRGDR TGRDQLAGGP LPEFPAGAQF SAFDQRCIPR SVCLRQCLLE PLSLTHLCET
LEKCPGPLEV KLSCEVLSDQ SLETLLNHLP RLPQLSLLQL SETRLSPRSP LLLANLFSLC
PQVQKVDLRS LYHTTLHFRS SEEQKGEFCG RFMDCALSRE HVEPLCWLLS KCEDLNQLDL
SANLLGDDGL QCLLECLPQL PISASLDLSH NSISVEGALC LVKTLPSCPR VREASVNLGS
EQSFWIHFSR QEEAGKTLRL SQCSFRPEHV PRLATGLNQA LKPTALTLTQ CCLGLEQLTV
LLSLVRWPVG LFNLRVEEPW VGKAGVLALL EVCTQASGNI TEISIAEAQQ QLCLQLEFPR
QENPEAVALR LAHCDLGTHH SLLVWQLMET CARLRQLSLS QVNLCDTSSL LLQSLLPSLS
ELKTFRLTCS CVRSEGLAHL TSGLSHCLHL EELDLSNNQF GEEGTRVLMG VLEGKCWLKR
LDLSHLPLGG SILAVLTQRL RHMTLLQSLR LSHNQIGDTG AQLLAVVLPW LPELRKIDLS
GNGIGPAGGA RLAESLALCR HLEQLMLGCN ALGDATALGL AQGLPRHLRI LHLPSSRLGP
EGALSLSQAL DGCPYVEEVS LAENSLARGI PQFCQGLPLL RRIDLVSCDI DDHTAKPLAA
SLLLCPALEE ILLSWNVLGD EAAAELARVL PQMGRLKRMD LEKNRITACG AWLLAEGLAQ
GSGIQVIRLW NNPIPPDTVQ RLQKQEPRLD FAFFDKQPKA PWGT
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