ID M3VZT3_FELCA Unreviewed; 1103 AA.
AC M3VZT3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Leucine rich repeats and immunoglobulin like domains 1 {ECO:0000313|Ensembl:ENSFCAP00000002900.6};
GN Name=LRIG1 {ECO:0000313|Ensembl:ENSFCAP00000002900.6,
GN ECO:0000313|VGNC:VGNC:80612};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000002900.6, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000002900.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000002900.6,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000002900.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000002900.6,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000002900.6}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000002900.6};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04000016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3VZT3; -.
DR STRING; 9685.ENSFCAP00000002900; -.
DR PaxDb; 9685-ENSFCAP00000002900; -.
DR Ensembl; ENSFCAT00000003150.6; ENSFCAP00000002900.6; ENSFCAG00000003151.6.
DR VGNC; VGNC:80612; LRIG1.
DR eggNOG; KOG4194; Eukaryota.
DR GeneTree; ENSGT00940000158502; -.
DR HOGENOM; CLU_000288_18_24_1; -.
DR InParanoid; M3VZT3; -.
DR OMA; HDTIERS; -.
DR OrthoDB; 5405965at2759; -.
DR Proteomes; UP000011712; Chromosome A2.
DR Bgee; ENSFCAG00000003151; Expressed in uterus and 9 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0022405; P:hair cycle process; IEA:Ensembl.
DR GO; GO:0060384; P:innervation; IEA:Ensembl.
DR GO; GO:0032474; P:otolith morphogenesis; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR CDD; cd05763; IgI_LRIG1-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR45842:SF12; KEKKON 5, ISOFORM A; 1.
DR PANTHER; PTHR45842; SYNAPTIC ADHESION-LIKE MOLECULE SALM; 1.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF13855; LRR_8; 5.
DR Pfam; PF01463; LRRCT; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00365; LRR_SD22; 8.
DR SMART; SM00369; LRR_TYP; 14.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS51450; LRR; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..1103
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023878547"
FT TRANSMEM 794..817
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 496..595
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 600..689
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 694..780
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 930..1017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1079..1103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 937..968
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1103 AA; 120155 MW; 3C7513EF30192B8D CRC64;
MARPVRGAFG APRRSPCPLL WLLLLLLRLG PATAAAGPRP PCAAACTCAG DSLDCGGRGL
AALPPDLPAW TRSLNLSYNR LSEIDPAGFE DLPNLQEVYL NNNELTAIPS LGAASSHVVS
LFLQHNKIRS VEGSQLKAYL SLEVLDLSSN NITEIRSACF PQGLHIRELN LASNRIGSLE
SGAFDGLSRS LVMLRLSKNR ITQLPVKAFK LPRLTQLDLN RNRIRLIEGL TFQGLESLEV
LKLQRNNISK LTDGAFWGLS RIHVLHLESN SLVEVNSGSL YGLSALQQLH LSGNSITRIN
RDGWSFCQRL QELVLSFNNL TRLDEESLAD LSSLSILRLS HNSISHIAEG AFRGLKNLRV
LDLDHNEISG TIEDTSGAFT GLDSLSKLTL FGNKIKSVAK RAFSGLEGLE HLNLGENAVR
SVQSDAFVKM KNLKELHISS DSFLCDCQLK WLPPWLLGRM LQPFVTATCA HPESLKGQSI
FSVPPESFVC DDLPKPQIIT QPEPTMAVVG KDIRFTCSAA SSSSSPMTFA WKKDNEVLAN
ADMENFAHVR AQDGVVMEYT TILHLRRVTF GHEGRYQCVI TNHFGSTYSH KARLVVNVLP
SFTKIPHDIA IRTGTMARLE CAATGHPNPQ IAWQKDGGTD FPAARERRMH VMPDDDVFFI
TDVKIDDMGV YSCTAQNSAG TVSANATLTV LETPSLVVPL EDRVVSMGET VALQCKATGS
PAPRITWFKG NRPLSLTERH HFTPGNQLLV VQNVVVEDAG QYTCEMSNAL GTERAHSQLS
ILPTPGCRKD GTTVGIFTIA VVCSIVLTSL VWVCIIYQTR KKSEEYSVTN TDETIVPPDV
PSYLSSQGTL SDRQETVIRT EGGHQANGHI ESNGVCPRDT SLFSEVDTHG MTCRQPKPCA
GYNKEPWAVT EKAQRRPGPQ KMEHSSLVVC GDYTTDPDSS CKEQASRPQP VPRDHTQAGT
LSGPEPSQSD REHSPHHLTG GTVDGSRADC RGSLYPSNHD RMPASLKKKP TAPLDGKGAS
SWTLARLCES DSVDLQPPLT LTPGSPELTE ASSGCPDIPG EGQHLLLYNG HLPKACDSSP
EYPPLTGQPP GKRGVPLLFA PKI
//
