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Database: UniProt
Entry: M3VZU4_FELCA
LinkDB: M3VZU4_FELCA
Original site: M3VZU4_FELCA 
ID   M3VZU4_FELCA            Unreviewed;      2017 AA.
AC   M3VZU4;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   30-AUG-2017, entry version 38.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN5A {ECO:0000313|Ensembl:ENSFCAP00000002913};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000002913, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000002913, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000002913,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000002913}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000002913};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000002913}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000002913};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSFCAP00000002913}.
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DR   EMBL; AANG02186520; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02186531; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9685.ENSFCAP00000002913; -.
DR   Ensembl; ENSFCAT00000003163; ENSFCAP00000002913; ENSFCAG00000003161.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; M3VZU4; -.
DR   OMA; TWDFCCG; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000011712; Chromosome C2.
DR   Bgee; ENSFCAG00000003161; -.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008053; Na_channel_a5su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01666; NACHANNEL5.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    254    274       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    389    417       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    718    736       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    748    769       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    775    797       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    837    860       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    880    897       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    917    940       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1208   1227       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1248   1264       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1276   1297       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1325   1351       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1447   1473       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1532   1550       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1562   1580       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1592   1612       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1649   1677       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1752   1775       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      134    423       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      479    667       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      718    944       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      954   1203       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1207   1482       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1531   1785       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      414    445       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2017 AA;  227685 MW;  A48C34297796DAA9 CRC64;
     MADFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGSAASQ ESREGLPEEE APRPQLDLQA
     SRKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK TIFRFSATNA LYVLSPFHPI
     RRAAVKILVH SYPLHMLIMC TILTNCVFMA QHDPPPWTKY VEYTFTAIYT FESLVKILAR
     GFCLHAFTFL RDPWNWLDFS VIVMAYTTEF VDLGNVSALR TFRVLRALKT ISVISGLKTI
     VGALIQSVKK LADVMVLTVF CLSVFALIGL QLFMGNLRHK CVRNFTALND TNGSVEADGL
     VWKSLDHYLN DPENYLLKNG TSDVLLCGNS SDAGTCPEGY RCLKAGENPD HGYTSFDSFA
     WAFLALFRLM TQDCWERLYQ QTLRSAGKIY MIFFMLVIFL GSFYLVNLIL AVVAMAYEEQ
     NQATIAETEE KEKRFQEAME MLKKEHEALA IRGVDTVSRS SLEMSPLAPV THERRRKRSK
     RMSSGTEECG DDRFPKSDSE DGPRATNRLS SAHGLSRTSV KPRSSRGSIF TFRRRDLGSE
     TDFADDENST AGDSESHRTS LLVPWPLRRP SAQGQPSPGT SALSHALNGK RNSTVDCNGV
     VSLLGTGDPE ATSPGSRLLR PVILDRPPDT TTPSEEPGRP QMLYPQAPRA DGFEGPGERQ
     RALSAVSVLT SALEELEESH RKCPPCWTRF AQRYLIWECC PLWMSIKQRV KFMVMDPFAD
     LTITMCIVLN TLFMALEHYN MTTEFEEMLQ VGNLVFTGIF TAEMTFKIIA LDPYYYFQGW
     NIFDSIIVIL SLMELGLSRM GNLSVLRSFR LLRVFKLAKS WPTLNTLIKI IGNSVGALGN
     LTLVLAIIVF IFAVVGMQLF GKNYSELRHR ISDSGLLPRW HMMDFFHAFL IIFRILCGEW
     IETMWDCMEV SGQSLCLLVF LLVMVIGNLV VLNLFLALLL SSFSADNLTA PDDDGEMNNL
     QLALARIQRG LRFLKRTTWD FCCGLLQRRP QKPAALAAHG QLPRCVATSS SPPPPPPEPE
     KAPPARKETR FEEDKRPGQG TPGDTEPVCV PIAVAESDTD EQEEEEENSL GTEEESSKQQ
     ESQPVSGSPE ALPKPRAWSQ VSETPSSEAE ASVAQADWRQ QRRVEPPAPG CSETQEDSYS
     EGSTADMTNT ADLLEQIPDL GEDVKDPEDC FTEGCVRRCP CCAVDTTQAP GKVWWRLRKT
     CYRIVEHSWF ETFIIFMILL SSGALAFEDI YLEERKTIKV LLEYADKMFT YVFVLEMLLK
     WVAYGFKKYF TNAWCWLDFL IVDVSLISLV ANTLGFAEMG PIKSLRTLRA LRPLRALSRF
     EGMRVVVNAL VGAIPSIMNV LLVCLIFWLI FSIMGVNLFA GKFGRCINQT EGDLPLNYTI
     VNNKSDCESF NVTGELYWTK VKVNFDNVGA GYLALLQVAT FKGWMDIMYA AVDSRGFEEQ
     PQWEYNLYMY IYFVIFIIFG SFFTLNLFIG VIIDNFNQQK KKLGGQDIFM TEEQKKYYNA
     MKKLGSKKPQ KPIPRPLNKY QGFLFDIVTK QAFDVTIMFL ICLNMVTMMV ETDDQSPEKV
     NILAKINLLF VAIFTGECII KMAALRHYYF TNSWNIFDFV VVILSIVGTV LSDIIQKYFF
     SPTLFRVIRL ARIGRILRLI RGAKGIRTLL FALMMSLPAL FNIGLLLFLV MFIYSIFGMA
     NFAYVKWEAG IDDMFNFQTF ANSMLCLFQI TTSAGWDGLL SPILNTGPPY CDPNLPNSNG
     SRGNCGSPAV GILFFTTYII ISFLIVVNMY IAIILENFSV ATEESTEPLS EDDFDMFYEI
     WEKFDPEATQ FIEYSALSDF ADALSEPLRI AKPNQISLIN MDLPMVSGDR IHCMDILFAF
     TKRVLGESGE MDALKIQMEE KFMAANPSKI SYEPITTTLR RKHEEVSATV IQRAFRRHLL
     QRSMKHASFL FRQQAGSSGL SEEDAPEQEG LIAHVMNENF SRRRGPPSTS STSSPPSYDS
     VTRATSDNPQ VRVSDCSRSE DLADFPASPD RDRESIV
//
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