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Database: UniProt
Entry: M3VZU6_FELCA
LinkDB: M3VZU6_FELCA
Original site: M3VZU6_FELCA 
ID   M3VZU6_FELCA            Unreviewed;      1965 AA.
AC   M3VZU6;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   25-OCT-2017, entry version 43.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN10A {ECO:0000313|Ensembl:ENSFCAP00000002915};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000002915, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000002915, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000002915,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000002915}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000002915};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000002915}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000002915};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSFCAP00000002915}.
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DR   EMBL; AANG02186564; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02186566; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02186567; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9685.ENSFCAP00000002915; -.
DR   Ensembl; ENSFCAT00000003166; ENSFCAP00000002915; ENSFCAG00000003166.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; M3VZU6; -.
DR   OMA; WNIFDCI; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000011712; Chromosome C2.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0044325; F:ion channel binding; IEA:Ensembl.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086016; P:AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0086043; P:bundle of His cell action potential; IEA:Ensembl.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IEA:Ensembl.
DR   GO; GO:0055117; P:regulation of cardiac muscle contraction; IEA:Ensembl.
DR   GO; GO:0002027; P:regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028809; Na_channel_a10su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF208; PTHR10037:SF208; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    128    146       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    222    243       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    249    268       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    382    409       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    704    726       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    793    813       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    876    899       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1162   1180       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1201   1217       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1229   1248       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1293   1313       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1364   1384       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1404   1427       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1477   1500       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1520   1538       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1550   1569       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1605   1633       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1708   1731       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      129    415       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      675    903       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      913   1156       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1160   1436       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1485   1741       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      406    440       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1965 AA;  221025 MW;  80466D7480036DD5 CRC64;
     MAFPFGSLET TNFRRFTPES LVEIEKRITA KQAAKKAKDK HREQKDQEEK PRPQLDLKAC
     NQLPKFYGDL PAELVGEPLE DLDPFYSTHR TFMVLNKGRT ISRFSATRAL WLFSPFNLIR
     RTAIKVSVHS WFSLFITVTI LVNCVGMTQT ELPERIEYVF TVIYTFEALI KILARGFCLN
     EFAYLRDPWN WLDFSVITLA YIGEAIDLRG ISGLRTFRVL RALKTVSVIP GLKVIVGALI
     HSVKKLADVT ILTVFCLSVF ALVGLQLFKG NLKNKCVKNC TALNETGNYS SYGKHEWNFC
     QEDEDFYYNK PGTSDPLLCG NGSDAGHCPE GYFCLKTSDN PDFNYTSFDS FAWAFLSLFR
     LMTQDSWERL YQQTLRASGK MYMVFFVLVI FLGSFYLVNL ILAVVTMAYE EQNQATIDEI
     EAKEKKFQEA LEMLRKEQEV LAALGIDSAS LHSHNGSPLA SKTASERMPR MKPRVSEGST
     DDSKSPQSDP YNQRRMSFLG LTSGRRRASH GSVFHFRAPC LDASFPDGAT DDGVFPGDRD
     SRRGSLLLGG GAGQQGPLPR SPLPQPSNPG SGLGEDGHST LPTGELAPGG IEVSAFDAGQ
     KKTFLSAEYL NEPFRAQRAM SVVSIMTSVL EEFEESEQRC PPCLTSLAKK YLIWECCPTW
     VKLKTLLFGI VTDPFAELTI TLCIVVNTVF MAMEHHRMSP AFEAMLQIGN IVFTVFFTAE
     MVFKIIAFDP YYYFQKRWNI FDCIIVTVSL IELGAAKKGS LSVLRTFRLL RVFKLAKSWP
     TLNTLIKIIG NSVGALGNLT IILAIIVFVF ALVGKQLLGD NYRDNRHNIS APNEEWPRWH
     MHDFFHSFLI VFRILCGEWI ENMWACMEVG QKSICLILFL TVMVLGNLVV LNLFIALLLN
     SFSADNLTAP DEDGEVNNLQ MALARIQAFG HRTRKALCSF FSRPRLLPWP KAEPQLAVKL
     PLSSAKAENH IAPDVATGSP EGLPEPPGPR VNHSDFITNP SIWVSVPIAE GESDLDDLEE
     DGEEDGEEDD EEVTPQEQQE QPQQVGRYED HMAPRSPGSG MSSEDLAPHL GEKWKDESAA
     RGPAEGVDDT SSSEGSTVDC LDPEEILKKI PELADDLEEP DDCFTEGCIH HCPCCKVDAG
     KFPWAVGWQV RKACYRIVEH SWFESFIIFM ILLSSGSLAF EDYYLDQKPT VKALLEYTDR
     VFTFIFVFEM LLKWVAYGFK KYFTNAWCWL DFLIVNISLT SLIAKILQYS DVASIKALRT
     LRALRPLRAL SRFEGMRVVV DALVGAIPSI MNVLLVCLIF WLIFSIMGVN FFAGKFGRCV
     NKTNENLSLV PLSIVNNMSD CKDQNHTGSF FWVNMKVNFD NVAMGYLALL QVATFKGWMD
     IMYAAVDSRD VNLQPKWEDN VYMYLYFVIF IIFGGFFTLN LFVGVIIDNF NQQKKKLGGQ
     DIFMTEEQKK YYNAMKKLGS KKPQKPIPRP LNKYQGFVFD VVTRQAFDII IMVLICLNMI
     TMMVETDDQS EEKTKILNKV NQFFVAVFTG ECVMKVFALR HYYFTNGWNV FDFIVVVLSI
     GSLVFSAILT SLENYFSPTL FRVIRLARIG RILRLIRAAK GIRTLLFALM MSLPALFNIG
     LLLFLVMFIY SIFGMASFPH VRWEAGIDDM FNFQTFANSM LCLFQITTSA GWDGLLSPIL
     NTGPPYCDPN LPNSNGSRGN CGSPAVGILF FTTYIIISFL IVVNMYIAVI LENFNVATQE
     SSEPLSEDDF DMFYETWEKF DPEATQFITF SALSDFADTL SGPLRIPKPN QNILIQMDLP
     LVPGDKIHCL DILFAFTKNV LGESGELDSL KANIEEKFMA TNVSKASYEP IATTLRWKQE
     DISATVIQKA YRSYVLHRSK TISSPPGVPR AEEEAVSPQD EAFVGFMANE NCALPDKSES
     VSAVSFPPSY DSVTRGLSDQ VNMSTSSSMQ NEDEATSKKA TAPGP
//
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