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Database: UniProt
Entry: M3W0G7_FELCA
LinkDB: M3W0G7_FELCA
Original site: M3W0G7_FELCA 
ID   M3W0G7_FELCA            Unreviewed;      1893 AA.
AC   M3W0G7;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   07-JUN-2017, entry version 40.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN4A {ECO:0000313|Ensembl:ENSFCAP00000003234};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000003234, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000003234, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000003234,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000003234}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000003234};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000003234}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000003234};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSFCAP00000003234}.
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DR   EMBL; AANG02052037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02052038; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9685.ENSFCAP00000003234; -.
DR   Ensembl; ENSFCAT00000003505; ENSFCAP00000003234; ENSFCAG00000003505.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; M3W0G7; -.
DR   OMA; GNDTWYG; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000011712; Chromosome E1.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     98    117       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    129    147       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    192    211       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    223    244       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    250    270       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    386    413       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    743    770       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    782    805       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    817    841       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    862    890       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    920    937       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    949    975       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1208   1226       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1247   1269       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1339   1359       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1380   1400       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1420   1443       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1502   1520       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1532   1550       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1562   1582       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1619   1647       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1720   1746       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      127    419       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      753    979       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      989   1202       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1206   1451       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1501   1756       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      421    444       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1893 AA;  214092 MW;  391A0D62C8878106 CRC64;
     SSLPTLVPLG PESLRPFTRE SLAAIERRAV EEEARQQRNK QMEIEEPERK PRSDLEAGKS
     LPLIYGDPPP EVIGIPLEDL DPYYSDKKTF IVLNKGKAIF RFSATPALYM LSPFSIIRRG
     AIKVLIHSYP AMFIMITILT NCVFMTMSDP PSWSKHVEYT FTGIYTFESL IKMLARGFCI
     DDFTFLRDPW NWLDFSVIMM AYLTEFVDLG NISALRTFRV LRALKTITVI PGLKTIVGAL
     IQSVKKLSDV MILTVFCLSV FALVGLQLFM GNLRHKCVRW PPPFNDTNTT WYGNDTCTFD
     WDAYINDEGN FYFLEGANDA LLCGNSSDAG HCPEGYECIK AGRNPNYGYT SYDTFSWAFL
     ALFRLMTQDY WENLFQLTLR AAGKTYMIFF VVIIFLGSFY LINLILAVVA MAYAEQNEAT
     LAEDQEKEEE FQQMLEKFKK QQEELEKPGF SRAGGGGGRK WVCAEGEVGP DEAPGSSCPF
     LTISSSVGSI KASENGGSLV TSAPTLSAPL PQRLPPKLHR AQCRKRRGAP ILKHLERNSE
     SQCIHRAQRW TPCAPPLLTH RPRPPRLWKA GRQMGTQPTV KVKGQRSNSA RVESQVLHTK
     SLYCPYKSQE RGREGKGEGV KGREGGSKRR CPSHTVKPRS PWDCPPPSSP LSSSTSLLAH
     KLLVVTKEWE GEPSGGTSVC SRVALASSRP GKEDMGGILI RCVSTLFPEL EEAHQKCPPW
     WYKCAHKVLI WNCCTPWVKF KNIIHLIVMD PFVDLGITIC IVLNTLFMAM EHYPMTEEFD
     NVLTVGNLVF TGIFTAEMVL KLIALDPYEY FQQGWNIFDS IIVTLSLVEL GLANVQGLSV
     LRSFRLLRVF KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV GMQLFGKSYK
     ECVCKIAADC SLPRWHMHDF FHSFLIVFRI LCGEWIETMW DCMEVAGQAM CLTVFLMVMV
     IGNLVVLNLF LALLLSSFSA DSLAASDEDG EMNNLQIAIG RIKWGIGFAK AFLLGLLRGK
     ILSPKEIMLS LGGPEEAGAA EEAGESASED EKKEPPPEED DKDLKKDNHI LSHVGLVDGS
     PPSIELDHLN FINNPYLTIH VPIASEESDL EMPTEEDTDT FSEPEDGKQP PQPLDGNSSV
     CSTADYKPPE EDPEEQAEEN PEGEQPEECF TEACVQRCPF LYVDISQGRG KMWWTLRRAC
     FKIVEHNWFE TFIVFMILLS SGALAFEDIY IEQRRTIRTI LEYADKVFTY IFILEMLLKW
     VAYGFKVYFT NAWCWLDFLI VDVSIISLVA NWLGYSELGP IKSLRTLRAL RPLRALSRFE
     GMRVVVNALL GAIPSIMNVL LVCLIFWLIF SIMGVNLFAG KFYYCINTTN VKVNYDNVGL
     GYLSLLQVAT FKGWMDIMYA AVDSREKEEQ PQYEVNIYMY LYFVIFIIFG SFFTLNLFIG
     VIIDNFNQQK KKFGGKDIFM TEEQKKYYNA MKKLGSKKPQ KPIPRPQNKI QGMVYDCVTK
     QVFDITIMIL ICLNMVTMMV ETDDQSQLKV DILYNINMVF IIIFTGECVL KMLALRQYYF
     TVGWNIFDFV VVILSIVGLA LSDLIQKYFV SPTLFRVIRL ARIGRVLRLI RGAKGIRTLL
     FALMMSLPAL FNIGLLLFLV MFIYSIFGMS NFAYVKKESG IDDMFNFETF GNSIICLFEI
     TTSAGWDGLL NPILNSGPPD CDPTLENPGT SVRGDCGNPS IGICFFCSYI IISFLIVVNM
     YIAIILENFN VATEESSEPL GEDDFEMFYE TWEKFDPDAT QFIAYSRLSD FVDTLQEPLR
     IAKPNKIKLI TLDLPMVPGD KIHCLDILFA LTKEVLGDSG EMDALKETME EKFMAANPSK
     VSYEPITTTL KRKHEEVCAI KIQRAYRRHL LQR
//
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