ID   M3W0Z6_FELCA            Unreviewed;      1453 AA.
AC   M3W0Z6;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 4.
DT   24-JAN-2024, entry version 65.
DE   SubName: Full=FA complementation group A {ECO:0000313|Ensembl:ENSFCAP00000003499.6};
GN   Name=FANCA {ECO:0000313|Ensembl:ENSFCAP00000003499.6,
GN   ECO:0000313|VGNC:VGNC:62139};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000003499.6, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000003499.6, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000003499.6,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA   Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA   Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA   Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000003499.6, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000003499.6,
RC   ECO:0000313|Proteomes:UP000011712};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000003499.6}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000003499.6};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   EMBL; AANG04002512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003998418.1; XM_003998369.4.
DR   PaxDb; 9685-ENSFCAP00000003499; -.
DR   Ensembl; ENSFCAT00000003796.6; ENSFCAP00000003499.6; ENSFCAG00000003795.6.
DR   GeneID; 101081431; -.
DR   KEGG; fca:101081431; -.
DR   CTD; 2175; -.
DR   VGNC; VGNC:62139; FANCA.
DR   eggNOG; ENOG502QT8N; Eukaryota.
DR   GeneTree; ENSGT00390000007852; -.
DR   HOGENOM; CLU_005268_0_0_1; -.
DR   OrthoDB; 5400084at2759; -.
DR   Proteomes; UP000011712; Chromosome E2.
DR   Bgee; ENSFCAG00000003795; Expressed in embryonic head and 9 other cell types or tissues.
DR   GO; GO:0043240; C:Fanconi anaemia nuclear complex; IEA:InterPro.
DR   GO; GO:0036297; P:interstrand cross-link repair; IEA:InterPro.
DR   InterPro; IPR003516; FANCA.
DR   InterPro; IPR031729; Fanconi_A_N.
DR   PANTHER; PTHR12047; FANCONI ANEMIA GROUP A PROTEIN; 1.
DR   PANTHER; PTHR12047:SF2; FANCONI ANEMIA GROUP A PROTEIN; 1.
DR   Pfam; PF03511; Fanconi_A; 1.
DR   Pfam; PF15865; Fanconi_A_N; 1.
DR   PRINTS; PR00826; FANCONIAGENE.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT   DOMAIN          167..520
FT                   /note="Fanconi anaemia group A protein N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF15865"
SQ   SEQUENCE   1453 AA;  161885 MW;  704C11914C53B274 CRC64;
     MSDSQVEGAA STSGLGSRKR RWTELLAGRV KRQMCGPGTE QKLQESAVHL LRRHLNLNDL
     LLEVEGAPRK TLCLNQLIDP EACTNLSSSL IGSALRDQAS RLGVPVAVLS SRLVASSITQ
     ICVSDGESSH RVLLSAEQRK KLSSLLEVAQ YLLAHSMFSR FSLCQELWEV QGSLLLEVVW
     QLHIQNVVSF QELLESHADT QATVAWLFRN LCLLCEEMEA SPYNDIARAM LSDLVQMFVL
     RGFQKNSDLR RNVEPEQMGQ LAFVVLQRML IFALEALAAG MQDGSPQHKV VKCWFGVFCG
     HTYDRMISTD SPKRFFSHTL TQVLTHKPVL RVSDAVQMQK EWSFAKTHPL LTGLYRRLFT
     MLSPEELVGH LQEVLETHEV NWQHVLSCVS TLVICLPEAQ QLVKDWVARL LARAFENCDL
     DSMVTAFLVV RQAALEGPSV FPSYADWFQA SFGSSRGSHC CSKKTLVFLF KFLSDLVPFE
     APRYMQAHIL HPPLVPSKYR SLLTDYVTLA KTRLADLKVS LENMGLYEDL SSARDVTEPH
     SQAHQDVEKA IAVFEHTGRI PSAVMEASIF RRPYYTAHFL PALLTPRVLP KTPDPRAALI
     ESLRRADKIP PSLYSAYCQA CSTAEEKKPE SAAPGMKVEA VRAEGPLGPL AAALRELRAA
     MTDPTQYDVV AARVAVVSER LGAALGRAEE DGSSGGSQIQ LSVLTPGLEQ QEQEVADLLL
     TCFCQNLIVA SSFASPDRQG PWASRLVTAM CGRRLLPVVL TRLCQLLRHQ GPSLSASHVL
     GLAALVVHLA ESRSVLPEVH VGLPAPAEGL SVAEFFSSLL TFRTSETSLF CLKFCTAVIS
     YSLCKYSSLS RDTLCTCLSP ALVKKFQFII LRLFPEARDP LGPEDTADPP WRPLCQPSAD
     WQQAALCLWK QRTFQELLKE KEFHLTYRDW LRLELEIQPE VDCLSDTERW DFQQWAIHEY
     FLPRPSAAGG CDGDLQVACT VLVDVLIDFC QSSRSYNYSE NSDLVLSGCP GNRDIFSRLQ
     EMAAGLEQGP GAPRSCSPPQ GHFLFGVFRR RLQALASGWD VAARLQRQRE LLVYKWILLG
     LPPSIVVGRP QAGQPAAPDC TEFFHLVNSE LRNFSHGSAL THDLTVHFFR GLLSACSQSG
     DPSLTADLVL TACQTECPLV LTSALLWWPR LEPELRSRWR RCLQAPLPQE LQRLWEAQRF
     GRSCLLPDTA SPAPGPAWLS AAALYFEIQR DGKDSVKSQL ERLGCQGEEL LVFLFFFSLM
     GLLSSHLTPH GRPRQAVDTP KALDICAEIL GCLEKRRVSW LVLFQLTETG GGLGHVLLRL
     APDQYVRLLP FAFYSLLSYF DEDALTREDA FLHVAVDMYL KLIRLFVAGE TSALATVASR
     SRERRGQGDP VGLITEARRL LLRSIPRCPK ESFSNVAELL ATSADFDPDV RAALLSRRQA
     GPDADLYREP RLF
//