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Database: UniProt
Entry: M3W183_FELCA
LinkDB: M3W183_FELCA
Original site: M3W183_FELCA 
ID   M3W183_FELCA            Unreviewed;       709 AA.
AC   M3W183;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   28-MAR-2018, entry version 33.
DE   SubName: Full=Nicastrin {ECO:0000313|Ensembl:ENSFCAP00000003624};
GN   Name=NCSTN {ECO:0000313|Ensembl:ENSFCAP00000003624};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000003624, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000003624, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000003624,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000003624}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000003624};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000003624}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000003624};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
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DR   EMBL; AANG03024606; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03024607; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_011289415.1; XM_011291113.2.
DR   STRING; 9685.ENSFCAP00000003624; -.
DR   Ensembl; ENSFCAT00000003929; ENSFCAP00000003624; ENSFCAG00000003928.
DR   GeneID; 101090586; -.
DR   eggNOG; KOG2657; Eukaryota.
DR   eggNOG; ENOG410XT6X; LUCA.
DR   GeneTree; ENSGT00390000014633; -.
DR   InParanoid; M3W183; -.
DR   OMA; HMHAVIS; -.
DR   OrthoDB; EOG091G03DV; -.
DR   Proteomes; UP000011712; Chromosome F1.
DR   Bgee; ENSFCAG00000003928; -.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0070765; C:gamma-secretase complex; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0004175; F:endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0034205; P:amyloid-beta formation; IEA:Ensembl.
DR   GO; GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
DR   GO; GO:0006509; P:membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0002262; P:myeloid cell homeostasis; IEA:Ensembl.
DR   GO; GO:0007220; P:Notch receptor processing; IBA:GO_Central.
DR   GO; GO:0043085; P:positive regulation of catalytic activity; IEA:Ensembl.
DR   GO; GO:0016485; P:protein processing; IBA:GO_Central.
DR   GO; GO:0042098; P:T cell proliferation; IEA:Ensembl.
DR   InterPro; IPR008710; Nicastrin.
DR   PANTHER; PTHR21092; PTHR21092; 1.
DR   Pfam; PF05450; Nicastrin; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     33       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        34    709       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014132767.
FT   TRANSMEM    670    690       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   709 AA;  78521 MW;  23F4A3ED45173AF1 CRC64;
     MATAGGGSVA DPGCRSLLRL LSFCVLLAGL CRGNSVERKI YISLNKTAPC VRLLNATHQI
     GCQSSVSGDT GILHVVEKER DLQWVLTDGP NPPYVVLLEG ELFTRNLMEK LKGTTSRIAG
     LAVSLAKPRP ASGSSPSVQC PNDGFGIYSN SYGPEFAHCR EIPWNPLGDG LAYEDFSFPI
     FLLEDENETK VIKQCYRDHN LSPNGSAPTF PLCAMQLFSH MHAVISTVTC MRRSSIQSTF
     SINPEIVCDP LSDYNVWSML KPINISGALE PDDRVVVAAT RLDSRSFFWN VAPGAESAVA
     SFVTQLAAAE ALQKAPDALT LPRNVMFVFF QGETFDYIGS SRMVYDMEKG KFPVQLENID
     SFVELGQVAL RNSLELWMHT DPMSQKNESV HNQVEALLST LEKSGAGVPA VVLRRPNQSQ
     PLPPSSLQRF LRARNISGVV LADHSAVFHN HYYQSIYDTA ENINVSYPEW QSPEEDLNFV
     TDTAKALADV ATVLGRALYQ LAGGTNFSDT IQADPQTVTR LLYGFLVRAN NSWFQSILRQ
     DLRSYLGDGP LQHYIAVSSP TNTTYVVQYA LANLTGQVVD LPREQCQDPS KVPSENKDLY
     EYAWVQGPLN SNETDRLPRC VRSTARLARA LSPAFELRQW GSTEYSTWTE SRWKDIRARI
     FLVASRELEF ITLMVGFGIL VFSLVVTYCI NAKADVLFIT PREPGAVSY
//
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