ID M3W4P7_FELCA Unreviewed; 692 AA.
AC M3W4P7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Highly divergent homeobox {ECO:0000313|Ensembl:ENSFCAP00000005367.5};
GN Name=HDX {ECO:0000313|Ensembl:ENSFCAP00000005367.5,
GN ECO:0000313|VGNC:VGNC:62775};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000005367.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000005367.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005367.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000005367.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005367.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000005367.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005367.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}.
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DR EMBL; AANG04004376; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3W4P7; -.
DR STRING; 9685.ENSFCAP00000005367; -.
DR PaxDb; 9685-ENSFCAP00000005367; -.
DR Ensembl; ENSFCAT00000005783.6; ENSFCAP00000005367.5; ENSFCAG00000005781.6.
DR VGNC; VGNC:62775; HDX.
DR eggNOG; ENOG502QPZG; Eukaryota.
DR GeneTree; ENSGT00390000008591; -.
DR HOGENOM; CLU_025064_0_0_1; -.
DR InParanoid; M3W4P7; -.
DR OMA; QPCKIEP; -.
DR Proteomes; UP000011712; Chromosome X.
DR Bgee; ENSFCAG00000005781; Expressed in embryonic head and 5 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR PANTHER; PTHR11636:SF80; HIGHLY DIVERGENT HOMEOBOX; 1.
DR PANTHER; PTHR11636; POU DOMAIN; 1.
DR SMART; SM00389; HOX; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 436..500
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 438..501
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 55..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 672..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 692 AA; 77220 MW; 25E42717C08EFB76 CRC64;
MNLRSVFTVE QQRILQRYYE NGMTNQSKNC FQLILQCAQE TKLDFSVVRT WVGNKRRKMS
SKNSESGATT GTLPSTSLTA PDITVRNVVN ITRPSSQQSS WTSANNDDIV TDAYSPASSS
SRQGTTKHSD TQITEAHKIP IQKTASKNDT EFQLHIPVQR QVAHCKNASL LLGEKTIILS
RQTSVLNAGN SVYSHTKKNY GSSSMQASEM MVPQKPSMCH RPCKIEPVGI QRSYKPEHMS
LASQNLCGQK PPIRDPYCRT QNLEIREVFS LAVSDYPQRI LGGNAPQKPS SAEGTCLSIA
METGDADDEY AKEEELALMG AQIPSYSRFY ESGRSLGAEN QSTVLPGPGR NMPNSQMVNI
RDLADNVLYQ SRDYHLTPRT SLHSVATTMY SNTNPSRSNF SSHFASSNQL KLSQNQNNYQ
ISGNLTVPWI TGCSRKRALQ DRTQFSDRDL ATLKKYWDNG MTSLGSVCRE KIEAVATELN
VDCEIVRTWI GNRRRKYRLM GIEVPPPRGG PADFSEQPES GSLSALTSGE EAGPEVGEDN
DRNDEVSICL SEGSSQEESN EVPNEARVHK EEDHHAVSAD NVKIEIIDDE ESDMISNCEV
EQVNSLLDYK NEEVRFIENE LEIQKQKYFK LQTFVRSLIL AMKADDKEQQ QALLSDLPPE
LEEMDFNHAS PEPDDTSFSV SSLSEKNASD SL
//
