ID M3W533_FELCA Unreviewed; 673 AA.
AC M3W533;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 24-JAN-2024, entry version 67.
DE SubName: Full=Nephrocystin 1 {ECO:0000313|Ensembl:ENSFCAP00000005563.6};
GN Name=NPHP1 {ECO:0000313|Ensembl:ENSFCAP00000005563.6,
GN ECO:0000313|VGNC:VGNC:68531};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000005563.6, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000005563.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005563.6,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000005563.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005563.6,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000005563.6}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005563.6};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04003404; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3W533; -.
DR Ensembl; ENSFCAT00000005990.6; ENSFCAP00000005563.6; ENSFCAG00000005988.6.
DR VGNC; VGNC:68531; NPHP1.
DR eggNOG; ENOG502QU7K; Eukaryota.
DR GeneTree; ENSGT00390000007701; -.
DR HOGENOM; CLU_024987_1_0_1; -.
DR Proteomes; UP000011712; Chromosome A3.
DR Bgee; ENSFCAG00000005988; Expressed in testis and 10 other cell types or tissues.
DR CDD; cd11770; SH3_Nephrocystin; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR039687; NPHP1.
DR InterPro; IPR030642; NPHP1_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15176; NEPHROCYSTIN; 1.
DR PANTHER; PTHR15176:SF1; NEPHROCYSTIN-1; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 149..209
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 111..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 10..69
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 113..140
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..229
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 673 AA; 76302 MW; F3A8F5413AC54430 CRC64;
MLARRPRNPL QALQRRTQEL KLQVDGLLSE SQLKEALEAS KRRDIYQRCI QLKRAIDENK
DALQKLNKAD EPAPIGNYNQ KKEDEHSLLD KLTHQLQELA VSISRENITE IGALAEEEDD
DEEEESEDTG DEEETEEEEK QEHESQQQAT GKEYIAIGDF TAQQAGDLTF KKGEILLVIE
KKPDGWWIAK NTNGNKGLIP RTYLEPYNKE EGQDSSEEGS EEDTEVGDQT AEGAEVKQRT
DSHWNAVRKA ISEQINTIDV LTTMGAIPSG FRPSMLFQLL EEGNQFQASY FLQPELTPSQ
LAFRDLMWDA KAGTIKPIPS RVSFILTLWS CKMIPLPGTS IQVLSRHVSL CLFDGNKVLS
NIHTVRATWQ PKKPKTWTFS PQVTGILPCL LDGDCFIRSN SSSPDLGILF ELGISYIRNS
TGERGELSCG WVFLKLFDAS GIPIPAKTYE LFLNGGTPYE KGVEVDPSVS RKAHGNVFHQ
MMMMRRQPQL LVKLRSSNRR SRNLLSLLPE TLIGSMCSIH LLIFYRQILG DVLLKDRMSM
QSADLISNTV LATFPKLLEQ PDMMDALRSS WAEKESTLKR SEKRDKEFLK AMFLLVYHNC
MVPLLHSTLL PPYRWAEEET EAARWKVITD FLKQNQDGEG GLQALLSPHG VHEPFDISEQ
TYDFLGELRK NTA
//
