ID M3W5B5_FELCA Unreviewed; 4646 AA.
AC M3W5B5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=LDL receptor related protein 2 {ECO:0000313|Ensembl:ENSFCAP00000005687.5};
GN Name=LRP2 {ECO:0000313|Ensembl:ENSFCAP00000005687.5,
GN ECO:0000313|VGNC:VGNC:80266};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000005687.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000005687.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005687.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000005687.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005687.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000005687.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005687.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AANG04001482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9685.ENSFCAP00000005687; -.
DR PaxDb; 9685-ENSFCAP00000005687; -.
DR Ensembl; ENSFCAT00000006121.6; ENSFCAP00000005687.5; ENSFCAG00000006116.6.
DR VGNC; VGNC:80266; LRP2.
DR eggNOG; KOG1215; Eukaryota.
DR GeneTree; ENSGT00940000157232; -.
DR HOGENOM; CLU_000085_1_1_1; -.
DR InParanoid; M3W5B5; -.
DR Proteomes; UP000011712; Chromosome C1.
DR Bgee; ENSFCAG00000006116; Expressed in adult mammalian kidney and 9 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; IBA:GO_Central.
DR GO; GO:0030424; C:axon; IEA:Ensembl.
DR GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:Ensembl.
DR GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR GO; GO:0030139; C:endocytic vesicle; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005768; C:endosome; IEA:Ensembl.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0042562; F:hormone binding; IBA:GO_Central.
DR GO; GO:0051087; F:protein-folding chaperone binding; IEA:Ensembl.
DR GO; GO:0035904; P:aorta development; IEA:Ensembl.
DR GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR GO; GO:0060982; P:coronary artery morphogenesis; IEA:Ensembl.
DR GO; GO:0034311; P:diol metabolic process; IEA:Ensembl.
DR GO; GO:1904447; P:folate import across plasma membrane; IEA:Ensembl.
DR GO; GO:0030900; P:forebrain development; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0008584; P:male gonad development; IEA:Ensembl.
DR GO; GO:0030001; P:metal ion transport; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
DR GO; GO:0140058; P:neuron projection arborization; IEA:Ensembl.
DR GO; GO:0003148; P:outflow tract septum morphogenesis; IEA:Ensembl.
DR GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0070447; P:positive regulation of oligodendrocyte progenitor proliferation; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR GO; GO:0061156; P:pulmonary artery morphogenesis; IEA:Ensembl.
DR GO; GO:0006898; P:receptor-mediated endocytosis; IBA:GO_Central.
DR GO; GO:0044321; P:response to leptin; IEA:Ensembl.
DR GO; GO:0003139; P:secondary heart field specification; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR GO; GO:0060068; P:vagina development; IEA:Ensembl.
DR GO; GO:0003223; P:ventricular compact myocardium morphogenesis; IEA:Ensembl.
DR GO; GO:0003281; P:ventricular septum development; IEA:Ensembl.
DR GO; GO:0042359; P:vitamin D metabolic process; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 35.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 36.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 8.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722:SF11; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2; 1.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00057; Ldl_recept_a; 35.
DR Pfam; PF00058; Ldl_recept_b; 15.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 26.
DR SMART; SM00179; EGF_CA; 10.
DR SMART; SM00192; LDLa; 36.
DR SMART; SM00135; LY; 38.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 34.
DR SUPFAM; SSF63825; YWTD domain; 8.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01209; LDLRA_1; 16.
DR PROSITE; PS50068; LDLRA_2; 36.
DR PROSITE; PS51120; LDLRB; 22.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..4646
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023830696"
FT TRANSMEM 4417..4439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 477..519
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 520..566
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 567..611
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 751..793
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 794..835
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 836..879
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 880..923
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1476..1518
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1519..1561
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1564..1607
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1788..1830
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1881..1928
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1929..1970
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2198..2241
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2515..2558
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2559..2600
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3234..3276
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3328..3371
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3372..3414
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 4147..4189
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 4190..4233
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 4235..4276
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 4370..4404
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 4538..4570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4592..4646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4538..4552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 28..40
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 35..53
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 47..62
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 108..120
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 115..133
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 127..142
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 152..170
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 164..179
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 183..195
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 190..208
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 202..217
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 222..234
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 229..247
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 241..256
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1024..1036
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1031..1049
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1043..1058
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1065..1077
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1072..1090
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1084..1099
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1107..1119
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1114..1132
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1126..1141
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1147..1159
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1154..1172
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1166..1181
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1205..1220
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1269..1281
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1276..1294
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1288..1303
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2695..2707
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2702..2720
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2736..2748
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2743..2761
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2755..2770
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2783..2801
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2859..2871
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2866..2884
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2901..2913
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2908..2926
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2988..3000
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2995..3013
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3007..3022
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3027..3039
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3034..3052
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3070..3082
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3077..3095
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3089..3104
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3548..3560
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3555..3573
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3589..3601
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3596..3614
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3630..3642
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3637..3655
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3692..3707
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3720..3738
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3732..3747
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3752..3764
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3759..3777
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3771..3786
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3791..3803
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3798..3816
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3810..3825
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3835..3847
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3842..3860
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3884..3902
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3921..3933
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3928..3946
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3940..3955
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 4394..4403
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4646 AA; 521167 MW; 97B1548669C55326 CRC64;
MERGAAAVAC TLLLAFAACL APASGQECDS EHFRCEDGHC IPATWRCDGT RDCLDDTDEV
GCPPPSCKSN QFLCQGEGLC IPNFWECDND EDCEDGSDEH QHCPGRTCSS HQITCSNGEC
IPKEYRCDHV RDCSDGTDEK DCQYPTCEQL TCASGACYNS SQKCDGRIDC RDSSDESNCT
QECSQHEFQC DIGVCIPRIY VCDHYPDCED GSDERSCAYE TCRGNQFTCP NGYCISQNMV
CDGEDDCRDN GDENGCESST HRFHECYPGE WACPESGKCI PVLKVCDGTL DCPGGEDETN
ITKGRFCDVN LCFILSCEYQ CHPSPNGGIC HCPLGFVVDQ NNTRTCVDFD DCQIWGICDQ
MCEDRTGHHQ CHCAEGYVLE HQQHCKANTS SEQPFVIFSN GRDLLIGDIH GRTFSMLVES
QNHGVAVGVD FHNHLHRVFW TDTVQDKVFS VDINGLNIQE VVSLDDPENL AIDWINNKLY
LVETKVNRID MVNIDGSHRI TLITENLGHP RGIAVDPTVG YLFFSDWESL SGEPKVERAF
MDGTNRKDLV KTKLGWPAGI TLDIVLKRVY WVDCRFDYIE TVTYDGIQRK TVVHGGSLIP
HPFGISLFEG YVYFTDWTKM AVMKANKFTE TSPQVYLQTS LRPFGVTVYH SLRQPYVNNP
CGNNNGGCEQ VCVLSHRTDN DGLGYRCRCT FGFRLDVDNR HCVVVKQFLI FSSEVAVRGI
PFNLSTQEDV IVPVTGNPSF FVGVDFDAQE NTIFFSDTSK DMIFKQNING TGREILTANR
VESVESLTFD WISKNLYWTD ASYRSISVMR LADKSRRAII QNLNNPRSIV VHPIAGYIFF
TDWFRPAKIM RAWSDGSNLL PIVNTTLGWP NGLAIDWGAL RLYWVDAFFD KIEHSTFDGL
DRRNLGHIQQ MTHPFGLTVF GDYVFFTDWR LGAIVRVRKM DGGDMRVIRS GITNIMHVKS
YDANTQTGSN YCNRPTHPNG DCSHFCFPVP NFQRVCGCPY GMNLTSNHLT CQEDPSHEPP
LEQCGALSFP CSNGRCVPSH YRCDGVDDCH DNSDEHLCGK FNNSCASSAF TCSHGECIPA
HWKCDKQNDC VDGSDEQNCP SQAPTSCPAS LFTCDNNLCI PRSWLCDTDN DCADGSDEKN
CEFTETCLPS QFRCPDHRCI DLSFVCDGDK DCVDGSDENG CVINCTASQF KCASEGRCIS
NIYRCDGVFD CNDHSDEVDC STRPPGMCHP DEFQCQADGV CIPKSWECDG HPDCIFGSDE
HHGCAPKTCP STHFLCDNGN CIYRDWLCDG DNDCRDMSDE KDCPTQAFHC PSWQWQCPGH
SICVNLSAVC DGISDCPNGT DESPLCNQDS CSDSNGGCTH QCVQGPYGAQ CVCTSGYLLA
NDSKTCEDIY ECDIPGFCSQ HCYNVRGSFR CWCDKEYTLD TNGRTCKVTA SESLLLLVAS
RNQIVADNIT SQVHNIYSVV RNGSHIVAID FDSISSRVFW SDGGQGTIWS AFLNGTDRRV
LLNSGVTMTE SMVVDWVGRN LYWTDYALET IEVSKLDGTH RTVLISHNVS NPRGLALDPR
ISDHLMFWSD WGHHPRIERA SMDGSLRTVI VQDKIFWPSG ITIDYPNRLL YFIDSYLDYI
DYCDYNGQHR RQVIASDLIL RHPYALTIFE DSVYWTDRST YQVLQANKWH GGNQSVIIRN
IQQPLGVVAV HPVKQPNSEN SCASSSCSHL CLLSSQMPHL YSCACPSGWS LSYDSVTCLR
DNQPFLITVR YSVIFGISLN PEVKSNDAMV PIAGIMNGYD VEFDDSEQFI YWVENPGEIH
RVKTDGTNRT VLVSLSRLGS SMSLALDWIS RNLYYTNPGT MSIEVLKLRG DVRYKKTLIT
NDGTVLGVGI PVGITVDPAN GKLYWSDQGT DSGVPAKIAS ANMDGTFPKV LFTGNLEHLE
FITLDIKEQK LYWAVTSTGV IERGNVDGTN RMILVNHLSH PWGIAVYDSY LYYTDEHYEV
IERVDKATGD NKVVLRENIP NLRGLRVYHR HGTSFNGCSN NVNACQQICL PIPGGLFSCA
CASGLKLNPD NRTCSPYSSF LVVSMLSTIR GFSLQLSDHS EAMVPVAGQG RNALHVDVDV
FSGFIYWCDF SSSVTSYNAI RRIRPDGSSF TNIVTQGIGE NGVRGIAVDW VAGNLYFTNA
FVSETLIEVL RINTTYRRIL LKATVDRPRD IVVDPKNRYL FWADYGQSPK IERSFLDCTN
RTVLVSEGIV TPRGLAVDHS NRYVYWVDDS LDIIARIGME AEVSEVIRYG SRYPTPYAIT
VFGNSIIWVD RNLKKIFQAS KEPNSNESPT VIRDNINWLR DVTIFDQSVQ PRSPAEVNHN
PCLENNGGCT HFCFALPGLD TPKCGCAFGT LEGDGKSCAI PTENFLIFAL ENTLRSLHLD
PEDHSPPFQP ISVERVAVDL AYDDISNRIY FTQSLGSGNG QISYVNLNSG TRSSTAIISG
KGNPDGIAFD WINRRIYYSN YTNETINSMA EDGSKRTVIA HVSKPRAIVL DPCRGYMYWT
DWGTNAKIER ATLGGNFRVP IVNSSLVWPN GLTLDYENDL LYWADASLQK IERSTLTGTQ
REVIVNRAFH PFSLTLYGQY IYWTDWNTKK IYRANKYDGS GQMAMTMSFP FRPNGIRVIV
KNQQQCSNPC SEFNGGCSHI CAPGPNGAEC QCPHEGRWYL ANNKKYCIVD NGTRCDSSKF
TCLNGHCISE QWKCDNDNDC GDGSDELEIV CAFHTCPQTA FTCDNGRCVQ YHYRCDHYND
CGDNSDEAGC LFRDCNATSE FTCNNRRCIP LQFVCNGINN CHDNDTSDEK NCAERACLPG
YVKCQTTNIC IPHFYLCDED NDCGDMSDES PVFCAAHTCN NEEFHCTSGR CIPRHWYCDE
EADCPDGSDE PDTCEYHEAT CLSNEFKCDS GRCIRREWIC DGDNDCGDMS DEDERHHCDS
HSCSSSEFLC ANNVPPSRKC IPQSWVCDGD ADCTDGSDEH QNCTRRSCSG NDFTCSNGRC
VPHSYRCDRR DDCGDYSDER DCLYPTCSES EFTCQNGLCI YKQEVCDGEN DCRDGSDEEE
HLCHTPETTC PPHQFKCNNG NCIDMVKVCN HLDDCSDNSD EKGCGVNECN DPLLSGCDQN
CTDTLTSFYC SCRPGYKLMF DNRSCDDIDE CKETPFVCSQ KCENVMGSYI CKCAPGYLRE
PDGKSCRQNS NIEPYLIFSN RYYLRNLTLD GHFYSLILQG LGNAVALDFD RVEKRLYWID
AENKVIERMF LNKTNREIVI NHKLPAAESL AIDWVTRKLY WVDAYLNCLS VSDLDGRYRR
KLAEHCVDVN NTFCFENPRG IALHPQYGHV YWADWAHRAY IGRVGMDGVN KSVIISTKIE
WPNGITIDYT NDLLYWADAH LGYIEYSDLE GRHRHTVYDG TLSHPFAITI FEDIIYWTDW
NTRTVEKGNK YDGSDRTVLV NTTHKPFDIH VYHPYRQPVV NNPCGTNNGG CSHLCLITAG
GNGFTCECPD DFRTIHMGDL NFCLPKCSST QFLCANNEKC IPIWWKCDGQ RDCSDGSDEP
VLCPQRYCPL GQFQCKDGNC TSSHFLCNAH QDCPDGSDED QILCEHHRCE SNEWQCANKR
CIPEAWRCDS ENDCGDNSDE DVYNCASRIC QPGYFKCANN HCIPQGWKCD VDNDCGDYSD
EPVSECMSHR CDNHTEFSCR TNYRCVPQWA VCNGFDDCRD NSDEQGCEER TCKPLGEFRC
NNHHCIPLRW KCDGHNDCGD NSDEENCVPR ECSESEFRCD DQSCIPSRWV CDHTNDCGDN
SDERDCELKT CQPGYFQCQS GHCVPEQSKC DGTADCLDAS DEATCPTRFP NGAYCSATMF
ECKNHVCIRS SWKCDGDNDC GDGSDEELHL CLDVSCDSPY RFRCDNNRCI YKHELCNHVD
DCGDGSDEKE EQCVASTSRP CREDEFKCSN GHCISQHLVC DDVDDCGDHF DETGCNTGKE
RSCAENLCEQ NCTQLSEGGF ICSCRPGFKA SILDRNSCDD INECEQFGVC PQHCQNTKGS
YECSCAEGFR SVSDHYGKRC AADGNPPLLL LPENVRIRKY NLSSEKFSDY LEGEERIQAI
DYDWDPEGIG LSVIYYTVLG HGSEFGAIKR AYIPNFESGT NNLVSKVNLN LKYIMQPDGL
AVDWVGRHIY WSDAKSKRIQ VAKLDGRYTK WLISTQLDQP AAVVVNPKLG LMYWTDWGRE
PKIESAWMDG QHRNILVQED LGWPTGLTID YLNNDRIYWS DFKENNIESI KHDGTDRRIV
ANAAMNPYNL DIFEGQFYWI SKNKGEVWKQ DKFGQDEKEK MLMVNPWLTQ VRIFHQHRYD
RSVPNRCKNV CSHLCLLRPG GYSCACPQGS TFITGSTTDC NAAIESPINM PPPCRCMYGG
NCYFDENDLP KCKCPSGYMG KYCEIGLSKG VPPGTTAVAV LLTGILIIII GALAALGFFH
YRRTGSLLPS LPKLPSLSSL VKSSENGNGV TFRSGADVNM DIGVSGFGPE SAIDRSVVMS
EHFAMEMGKQ PIIFENPMYA SRDSDVKVVH QPTQVTVSGN VDNQNYGSPV NPSEIAPDTK
PASPSADTTQ ATKWSIFKRK LKPTTNFENP IYAEMENEHK DSTAVAPTPS PSLPAKSPRR
DPVPTYTATE DTFTDTANLV REDSEV
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